Subtype
High-Grade Glioma, NOS
CI-CAN-00009391Explore in graph →
75 active trials2 approved drugs11 evidence items
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Subtype
CI-CAN-00009391Explore in graph →
Clinical trials
173 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (30)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT04737577 | Glioma Supra Marginal Incision Trial(G-SUMIT) | completed | N/A | 44 | Sunnybrook Health Sciences CentreOTHER | 2 | Aug 20, 2026 | clinicaltrials |
| NCT02970448 | Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas | completed | Early Phase 1 | 13 | Case Comprehensive Cancer CenterOTHER | 1 | Aug 6, 2026 | clinicaltrials |
| NCT05644080 | 68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma | completed | N/A | 10 | St. Olavs HospitalOTHER | 1 | Jun 18, 2026 | clinicaltrials |
| NCT04911621 | Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma(ADDICT-pedGLIO) | completed | Phase 1 / Phase 2 | 10 | University Hospital, AntwerpOTHER | 1 | Jun 5, 2026 | clinicaltrials |
| NCT04988750 | Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients | completed | N/A | 7 | NaviFUS CorporationINDUSTRY | 1 | Apr 13, 2026 | clinicaltrials |
| NCT07499141 | Use of Fluorescence in Gliomas(UFGAG) | completed | — | 41 | Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di AlessandriaOTHER | 1 | Mar 30, 2026 | clinicaltrials |
| NCT02473380 | Fluorescence Spectroscopy Guided Surgery(GLIOSPECT) | completed | Phase 1 | 11 | Hospices Civils de LyonOTHER | 1 | Dec 19, 2025 | clinicaltrials |
| NCT03128047 | HUMC 1612: Optune NovoTTF-200A System | completed | Phase 1 | 7 | Hackensack Meridian HealthOTHER | 1 | Jul 8, 2025 | clinicaltrials |
| NCT05375318 | BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels(BIOhabitats) | completed | — | 50 | Juan M Garcia-GomezOTHER | 1 | Jul 8, 2025 | clinicaltrials |
| NCT05362409 | Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma | completed | Phase 1 | 22 | Alpheus Medical, Inc.INDUSTRY | 1 | Jun 19, 2025 | clinicaltrials |
| NCT04734444 | SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue | completed | N/A | 45 | SonoClear ASINDUSTRY | 3 | Jun 17, 2025 | clinicaltrials |
| NCT02655601 | Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001(BMX-HGG) | completed | Phase 1 / Phase 2 | 177 | BioMimetix JV, LLCINDUSTRY | 1 | Jun 8, 2025 | clinicaltrials |
| NCT04766632 | Contribution of Cerebral 18F-DOPA PET-CT Scan in High-grade Recurrent Gliomas(DORA) | completed | N/A | 16 | Central Hospital, Nancy, FranceOTHER | 1 | Jun 5, 2025 | clinicaltrials |
| NCT04267146 | Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade Glioma(NIVOGLIO) | completed | Phase 1 / Phase 2 | 41 | Gustave Roussy, Cancer Campus, Grand ParisOTHER | 1 | Dec 2, 2024 | clinicaltrials |
| NCT03294434 | Predicting Sites of Tumour Progression in the Invasive Margin of Glioblastomas (PRaM-GBM Study)(PRaM-GBM) | completed | — | 147 | CCTU- Cancer ThemeOTHER | 1 | Sep 27, 2024 | clinicaltrials |
| NCT03434262 | SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors | completed | Phase 1 | 68 | St. Jude Children's Research HospitalOTHER | 1 | May 31, 2024 | clinicaltrials |
| NCT00589875 | Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma(BrTK02) | completed | Phase 2 | 52 | Candel Therapeutics, Inc.INDUSTRY | 1 | Apr 3, 2024 | clinicaltrials |
| NCT03925246 | Efficacy of Nivolumab for Recurrent IDH Mutated High-Grade Gliomas(REVOLUMAB) | completed | Phase 2 | 43 | Assistance Publique - Hôpitaux de ParisOTHER | 1 | Apr 2, 2024 | clinicaltrials |
| NCT03458312 | Nurse-led Family and Network Consultations(CARES) | completed | N/A | 114 | Rigshospitalet, DenmarkOTHER | 1 | Nov 28, 2023 | clinicaltrials |
| NCT03425292 | A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer | completed | Phase 1 | 49 | Saint John's Cancer InstituteOTHER | 1 | Nov 8, 2023 | clinicaltrials |
| NCT02575794 | Terameprocol in Treating Patients With Recurrent High Grade Glioma | completed | Phase 1 | 20 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Oct 6, 2023 | clinicaltrials |
| NCT05873946 | Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery(2D-ioUS-Glio) | completed | — | 99 | Hospital del Rio HortegaOTHER | 1 | Sep 26, 2023 | clinicaltrials |
| NCT01466686 | Low Dose Radiation Therapy for Glioblastoma Multiforme | completed | Phase 2 | 31 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Jul 3, 2023 | clinicaltrials |
| NCT02022644 | Study of Convection-Enhanced, Image-Assisted Delivery of Liposomal-Irinotecan In Recurrent High Grade Glioma | completed | Phase 1 | 18 | University of California, San FranciscoOTHER | 1 | Jun 29, 2023 | clinicaltrials |
| NCT03355794 | A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) | completed | Phase 1 | 19 | Children's Hospital Medical Center, CincinnatiOTHER | 1 | Jan 13, 2023 | clinicaltrials |
| NCT02567539 | Hypofractionated Stereotactic Radiotherapy for Patients With Recurrent High Grade Glioma | completed | N/A | 88 | Istituto Clinico HumanitasOTHER | 1 | Sep 15, 2022 | clinicaltrials |
| NCT01808820 | Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma | completed | Phase 1 | 20 | Macarena De La Fuente, MDOTHER | 1 | Jul 20, 2022 | clinicaltrials |
| NCT03775369 | Glioma and Exercising | completed | N/A | 39 | University Hospital, Basel, SwitzerlandOTHER | 1 | May 18, 2022 | clinicaltrials |
| NCT01222754 | Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas | completed | Phase 1 | 29 | National Cancer Institute (NCI)NIH | 1 | Jan 3, 2022 | clinicaltrials |
| NCT01729260 | Mebendazole in Newly Diagnosed High-Grade Glioma Patients Receiving Temozolomide(Mebendazole) | completed | Phase 1 | 24 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | May 7, 2021 | clinicaltrials |
| NCT01390948 | A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Adolescent Participants With High-Grade Glioma | completed | Phase 2 | 124 | Hoffmann-La RocheINDUSTRY | 14 | Aug 6, 2020 | clinicaltrials |
| NCT01403610 | Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab | completed | Phase 2 | 28 | The University of Texas Health Science Center at San AntonioOTHER | 1 | Jul 24, 2019 | clinicaltrials |
| NCT02272270 | Phase I Newly Diagnosed GBM With Temozolomide, Radiation, and Minocycline Followed by Adjuvant Minocycline/Temozolomide (D-TERMINED)(D-TERMINED) | completed | Phase 1 | 25 | University of UtahOTHER | 1 | Jun 19, 2019 | clinicaltrials |
| NCT01644773 | Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine Glioma (DIPG) and High-Grade Glioma (HGG) | completed | Phase 1 | 36 | St. Jude Children's Research HospitalOTHER | 1 | Mar 22, 2019 | clinicaltrials |
| NCT02041611 | Prospective Evaluation of T-cell Immune Status in Patients With Newly Diagnosed High Grade Gliomas | completed | N/A | 20 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Jun 27, 2018 | clinicaltrials |
| NCT01172964 | A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas | completed | Phase 1 | 15 | City of Hope Medical CenterOTHER | 1 | Nov 9, 2017 | clinicaltrials |
| NCT01240161 | Personalized Translational Platform for Biomarker Discovery in Brain Tumors | completed | — | 37 | Marcelo F. Di Carli, MD, FACCOTHER | 1 | Aug 29, 2017 | clinicaltrials |
| NCT01191346 | Radiation Planning Study for High Grade Brain Tumors | completed | — | 24 | University of CincinnatiOTHER | 1 | Aug 22, 2017 | clinicaltrials |
| NCT00565721 | A Proof-of-concept Study to Assess the Ability of [18F]AH-111585 PET Imaging to Detect Tumours and Angiogenesis | completed | Phase 2 | 33 | GE HealthcareINDUSTRY | 1 | Aug 18, 2014 | clinicaltrials |
| NCT00780819 | Borderzone Sampling(BZS) | completed | N/A | 10 | Maastricht University Medical CenterOTHER | 1 | May 14, 2013 | clinicaltrials |
| NCT00897611 | Tumor DNA and MRI/CT Scan Findings in Patients With Grade III or Grade IV Malignant Glioma | completed | N/A | 42 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 0 | Nov 30, 2012 | clinicaltrials |
| NCT00624728 | Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP)(GLIO-TEP) | completed | Phase 1 / Phase 2 | 21 | University Hospital, BordeauxOTHER | 1 | May 4, 2012 | clinicaltrials |
| NCT00561873 | Nimotuzumab in Children With HGG | completed | — | 45 | Oncoscience AGINDUSTRY | 1 | Nov 21, 2007 | clinicaltrials |
Data updated 22 days agoSource updated Aug 20, 2026source: clinicaltrials