Clinical trial · Observational
Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery
Evaluating the Impact of 2D Non-Navigated Intraoperative Ultrasound on Extent of Resection and Patients' Outcome in Glioma Surgery: A Retrospective Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This retrospective study aims to assess the utility of 2D non-navigated intraoperative ultrasound (ioUS) as a cost-effective alternative for guiding the surgical resection of gliomas and for detecting residual tumor. The study will analyse the records from consecutive adult patients diagnosed with gliomas, undergoing craniotomy between June 2018 and June 2023. The extent of resection (EOR) will be determined using postoperative MRI as the gold standard. The study will also examine the sensitivity and specificity of ioUS in detecting residual tumor. This research seeks to determine if ioUS can be an affordable and reliable tool that, combined with other intraoperative adjuncts, may aid neurosurgeons in achieving the maximum safe resection in glioma surgery.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioblastoma | Glioblastoma | CURATED_BROADER | 0.80 |
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
| Glioma, Malignant | Malignant Glioma | ALIAS | 0.90 |
| High-grade Glioma | High-Grade Glioma, NOS | ONTOLOGY_EXACT | 0.90 |
| Low-grade Glioma | Low Grade Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| intraoperative ultrasound | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Operated gliomas
- description
- Patients consecutively operated with a pathological diagnosis of glial tumor
- interventionNames
- Diagnostic Test: intraoperative ultrasound
Primary outcomes (1)
- measure
- Extent of tumor resection
- timeFrame
- 24 hours after the surgery
- description
- Percentage of tumor removal
Secondary outcomes (1)
- measure
- Postoperative neurological deficit
- timeFrame
- From 24 hours to 30 days after the surgery
- description
- Neurological deficit after the surgery determined by physical examination
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients aged 18 years or older. * Patients diagnosed with gliomas, confirmed by a pathologist. * Patients who are scheduled to undergo craniotomy for tumor resection. * Patients who are willing and able to give informed consent for participation in the trial. * Patients who are capable of undergoing both intraoperative ultrasound and postoperative MRI. Exclusion Criteria: * Patients under the age of 18. * Patients with non-glioma brain tumors. * Patients who underwent stereotactic biopsies. * Patients who are unable to provide informed consent due to cognitive impairment, language barriers, or any other reason. * Patients with contraindications for MRI such as certain types of implanted medical devices, severe claustrophobia, or allergies to contrast material. * Pregnant or breastfeeding women.
References
Publications (1)
- DERIVEDCepeda S, Garcia-Garcia S, Arrese I, Sarabia R. Non-navigated 2D intraoperative ultrasound: An unsophisticated surgical tool to achieve high standards of care in glioma surgery. J Neurooncol. 2024 May;167(3):387-396. doi: 10.1007/s11060-024-04614-5. Epub 2024 Feb 28. PMID 38413458