Molecular Subtype
HER2-Positive Breast Carcinoma
CI-CAN-00007795Explore in graph →
140 active trials3 approved drugs93 evidence items
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Molecular Subtype
CI-CAN-00007795Explore in graph →
Clinical trials
377 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (52)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT04660929 | CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors | unknown | Phase 1 | 48 | Carisma Therapeutics IncINDUSTRY | 1 | Dec 18, 2024 | clinicaltrials |
| NCT05169853 | Programmed Death-Ligand1 Expression in Her-2 Positive and Triple Negative Breast Cancer | unknown | — | 80 | Ain Shams UniversityOTHER | 1 | Aug 20, 2024 | clinicaltrials |
| NCT06479460 |
| Clinical Application of ctDNA Dynamic Monitoring in Neoadjuvant Therapy for HER2-positive Breast Cancer Patients |
| unknown |
| — |
| 50 |
| The First Affiliated Hospital with Nanjing Medical UniversityOTHER |
| 1 |
| Jul 24, 2024 |
| clinicaltrials |
| NCT02993198 | A Prospective Study of Breast Cancer Patients With Abnormal Strain Imaging | unknown | Phase 2 | 134 | Northwestern UniversityOTHER | 1 | Jun 3, 2024 | clinicaltrials |
| NCT05982626 | Study of 68Ga /131I SGMIB-ZT-199 PET Imaging Targeting HER2-positive in the Diagnosis of Metastatic Breast Cancer | unknown | N/A | 10 | Huashan HospitalOTHER | 1 | Apr 24, 2024 | clinicaltrials |
| NCT03500380 | A Study of RC48-ADC Administered Intravenously to Patients With HER2-Positive Metastatic Breast Cancer With or Without Liver Metastases | unknown | Phase 2 / Phase 3 | 301 | RemeGen Co., Ltd.INDUSTRY | 1 | Feb 20, 2024 | clinicaltrials |
| NCT03812393 | Evaluating the Efficacy of Neratinib on Live Cell HER2 Signaling Transduction Analysis Positive Triple Negative Breast(FACT-2) | unknown | Phase 2 | 27 | West Cancer CenterOTHER | 1 | Dec 18, 2023 | clinicaltrials |
| NCT04450732 | Safety of GQ1001 in Adult Patients With HER2-Positive Advanced Solid Tumors | unknown | Phase 1 | 96 | GeneQuantum Healthcare (Suzhou) Co., Ltd.INDUSTRY | 3 | Dec 5, 2023 | clinicaltrials |
| NCT05912062 | Early On-treatment Transcriptional Profiling as Predictor of Response in Early-stage HER2-positive Breast Cancer(BiOnHER) | unknown | — | 80 | Institut Català d'OncologiaOTHER | 1 | Sep 29, 2023 | clinicaltrials |
| NCT05985187 | Clinical Study to Evaluate the Efficacy and Safety of TQB2440 Injection/Perjeta® Combined With Trastuzumab and Docetaxel in the Treatment of Patients With Early or Locally Advanced Breast Cancer. | unknown | Phase 3 | 412 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd.INDUSTRY | 1 | Aug 14, 2023 | clinicaltrials |
| NCT05945368 | A Trial of Eribulin in Combination With HP Neoadjuvant Therapy in Patients With for HER2-Positive BC | unknown | Phase 2 | 78 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER | 1 | Jul 14, 2023 | clinicaltrials |
| NCT05036005 | Neoadjuvant Ontruzant (SB3) in Patients With HER2-positive Early Breast Cancer: An Open-Label (NeoON)(NeoON) | unknown | Phase 4 | 108 | Institut fuer FrauengesundheitOTHER | 1 | Apr 18, 2023 | clinicaltrials |
| NCT05750693 | PIK3CA in HER2+ BC and pCR Trial | unknown | N/A | 58 | Fondazione Policlinico Universitario Agostino Gemelli IRCCSOTHER | 1 | Mar 2, 2023 | clinicaltrials |
| NCT04997798 | Dalpiciclib in Combination With Exemestane and Trastuzumab Plus Pyrotinib in Early Triple Positive Breast Cancer | unknown | Phase 2 | 30 | First Affiliated Hospital of Zhejiang UniversityOTHER | 1 | Feb 21, 2023 | clinicaltrials |
| NCT05720026 | Study to Evaluate the Efficacy and Safety of SYSA1901 vs. Perjeta® of HER2-Positive Breast Cancer | unknown | Phase 3 | 560 | CSPC ZhongQi Pharmaceutical Technology Co., Ltd.INDUSTRY | 1 | Feb 9, 2023 | clinicaltrials |
| NCT05692661 | A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer | unknown | Phase 1 | 24 | Shanghai Proton and Heavy Ion CenterOTHER | 1 | Jan 20, 2023 | clinicaltrials |
| NCT04582968 | Pyrotinib Combined With Brain Radiotherapy in Breast Cancer Patients With Brain Metastases | unknown | Phase 1 / Phase 2 | 39 | Fudan UniversityOTHER | 1 | Jan 18, 2023 | clinicaltrials |
| NCT04288141 | A Study to Measure the Expression of the HER2-HER3 Dimer in Tumour and Blood (Exosomes) Samples From Patients With HER2 Positive Breast Cancer Receiving HER2 Targeted Therapies(HERdi PREDICT) | unknown | — | 40 | King's College LondonOTHER | 1 | Nov 14, 2022 | clinicaltrials |
| NCT03907800 | Neoadjuvant Nab-paclitaxel in Triple-negative or HER2-positive Breast Cancer(NeoPATH) | unknown | Phase 2 | 100 | Ruijin HospitalOTHER | 1 | Oct 27, 2022 | clinicaltrials |
| NCT05561686 | Real-world Study of Pyrotinib in Neoadjuvant Therapy for HER2-positive Breast Cancer | unknown | — | 100 | Hunan Cancer HospitalOTHER | 1 | Sep 30, 2022 | clinicaltrials |
| NCT05429294 | Novel Double Target Therapy Combined With Chemotherapy in First-line Treatment of HER2+ Breast Cancer, MA-BC-II-038 | unknown | Phase 2 | 209 | First Affiliated Hospital Xi'an Jiaotong UniversityOTHER | 1 | Jun 23, 2022 | clinicaltrials |
| NCT03913234 | Phase IB & II Study of Ribociclib With Trastuzumab Plus Letrozole in Postmenopausal HR+, HER2+ Advanced Breast Cancer Patients | unknown | Phase 1 / Phase 2 | 95 | Yonsei UniversityOTHER | 1 | May 10, 2022 | clinicaltrials |
| NCT04605575 | Pyrotinib Plus Vinorelbine in Participants With HER2-positive Previously Treated Locally Advanced or Metastatic Breast Cancer | unknown | Phase 2 | 208 | Sun Yat-sen UniversityOTHER | 1 | Apr 26, 2022 | clinicaltrials |
| NCT05346107 | PLD-cyclophosphamide-Nab-P Continuously Combined With Dual HER2 Blockage for HER2-positive Breast Cancer | unknown | Phase 2 | 100 | Xijing HospitalOTHER | 1 | Apr 26, 2022 | clinicaltrials |
| NCT05346861 | Pyrotinib Rechallenge in Her2-positive Metastatic Breast Cancer Pretreated With Pyrotinib and Trastuzumab | unknown | Phase 3 | 240 | Fudan UniversityOTHER | 1 | Apr 26, 2022 | clinicaltrials |
| NCT05334810 | DP303c in Patients With HER2-positive Unresectable Locally Advanced, Relapsed, or Metastaticbreast Cancer | unknown | Phase 2 | 191 | CSPC ZhongQi Pharmaceutical Technology Co., Ltd.INDUSTRY | 0 | Apr 19, 2022 | clinicaltrials |
| NCT04457700 | CT-based Radiomics of ALN pCR (ypN0) in Breast Cancer Undergoing NAC | unknown | — | 218 | Peking UniversityOTHER | 1 | Apr 18, 2022 | clinicaltrials |
| NCT05189067 | Efficacy and Safety of Adjuvant Docetaxel and Trastuzumab in Stage I HER2-positive Breast Cancer | unknown | Phase 2 / Phase 3 | 190 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Jan 12, 2022 | clinicaltrials |
| NCT05154396 | Neratinib Dose Escalation Regimen for HER2 Positive Early Breast Cancer | unknown | Phase 2 | 60 | Chinese Academy of Medical SciencesOTHER | 0 | Dec 13, 2021 | clinicaltrials |
| NCT03238495 | Randomized Trial of Neo-adjuvant Chemotherapy With or Without Metformin for HER2 Positive Operable Breast Cancer(HERMET) | unknown | Phase 2 | 100 | Qamar KhanOTHER | 1 | Dec 7, 2021 | clinicaltrials |
| NCT05134519 | RC48 for Neoadjuvant Chemotherapy of HER2 Positive Breast Cancer | unknown | Phase 2 | 20 | Xijing HospitalOTHER | 0 | Nov 26, 2021 | clinicaltrials |
| NCT05076695 | Neoadjuvant With Trastuzumab, Pyrotinib Plus Palbociclib and Fulvestrant in HER2-positive, ER-positive Breast Cancer(NeoTPPF) | unknown | Phase 2 | 37 | Fudan UniversityOTHER | 1 | Oct 13, 2021 | clinicaltrials |
| NCT05063643 | Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude | unknown | — | 132 | Affiliated Hospital of Qinghai UniversityOTHER | 1 | Oct 1, 2021 | clinicaltrials |
| NCT03655353 | A Study of 68Ga-ABY-025 PET for Non-invasive Quantification of HER2-expression in Advanced Breast Cancer(Affibody-3) | unknown | N/A | 160 | Henrik LindmanOTHER | 1 | Sep 29, 2021 | clinicaltrials |
| NCT03521245 | Molecular Pathway Activation Markers Predicting Efficacy of Trastuzumab Therapy for HER2-positive Breast Cancer | unknown | — | 40 | OmicsWay Corp.INDUSTRY | 2 | Sep 14, 2021 | clinicaltrials |
| NCT05019365 | Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy | unknown | — | 60 | University of GlasgowOTHER | 1 | Aug 24, 2021 | clinicaltrials |
| NCT04760431 | TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN) | unknown | Phase 2 | 120 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Jun 2, 2021 | clinicaltrials |
| NCT04170595 | Clinical Study of Recombinant Anti-HER2 Humanized Monoclonal Antibody for Injection | unknown | Phase 1 / Phase 2 | 132 | Genor Biopharma Co., Ltd.INDUSTRY | 1 | Mar 3, 2021 | clinicaltrials |
| NCT03698383 | Phase II Study of Herzuma® Plus Gedatolisib in Patients With HER-2 Positive Metastatic Breast Cancer | unknown | Phase 2 | 15 | Korean Cancer Study GroupOTHER | 1 | Feb 18, 2021 | clinicaltrials |
| NCT04609540 | Pyrotinib Combined With Trastuzumab And Chemotherapy in HER2-positive MBC | unknown | — | 200 | Shandong Cancer Hospital and InstituteOTHER | 0 | Dec 16, 2020 | clinicaltrials |
| NCT04639271 | Pyrotinib, Trastuzumab And Abraxane in HER2-positive MBC With Brain Metastasis | unknown | Phase 2 | 100 | Shandong Cancer Hospital and InstituteOTHER | 1 | Nov 20, 2020 | clinicaltrials |
| NCT03933319 | Phase Ⅱ Study of Pegylated Liposomal Doxorubicin（PLD）Plus Trastuzumab in HER-2 Positive Metastatic Breast Cancer | unknown | Phase 2 | 30 | Chinese Academy of Medical SciencesOTHER | 1 | Jul 8, 2020 | clinicaltrials |
| NCT04158947 | A Study of HER2+ Breast Cancer Patients With Active Brain Metastases Treated With Afatinib & T-DM1 vs. T-DM1 Alone(HER2BAT) | unknown | Phase 2 | 130 | xuexin heOTHER | 1 | May 12, 2020 | clinicaltrials |
| NCT04158505 | Real World Study of Pyrotinib in Human Epidermal Growth Factor Receptor-2 (HER2) Positive Breast Cancer | unknown | — | 3,000 | Chinese Academy of Medical SciencesOTHER | 1 | Apr 24, 2020 | clinicaltrials |
| NCT04337658 | Anti-HER2 Therapy + Fulvestrant/Capecitabine in Women With HR+, HER2+, Non-visceral Metastases Stage IV Breast Cancer(FAVOR) | unknown | Phase 3 | 493 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Apr 8, 2020 | clinicaltrials |
| NCT04276337 | Genetic Characteristics of HER2 Positive Breast Cancer With Neoadjuvant TCHP Chemotherapy | unknown | — | 50 | Samsung Medical CenterOTHER | 1 | Feb 19, 2020 | clinicaltrials |
| NCT04236310 | A Study of Neoadjuvant SHR6390 in Combination With Anastrozole, Pyrotinib, and Trastuzumab in Patients With ER+/HER2+ Breast Cancer. | unknown | Phase 2 | 37 | Ruijin HospitalOTHER | 0 | Jan 22, 2020 | clinicaltrials |
| NCT04094896 | TCHP Versus EC -THP as Neoadjuvant Treatment for HER2-Positive Breast Cancer | unknown | Phase 2 | 200 | Guangdong Provincial People's HospitalOTHER | 1 | Sep 19, 2019 | clinicaltrials |
| NCT04095390 | A Phase Ⅱ Trial of Pyrotinib Combination With CDK4/6 Inhibitor SHR6390 in Patients Prior Trastuzumab-treated Advanced HER2-Positive Breast Cancer(INPHASE) | unknown | Phase 2 | 60 | Jinming YuOTHER | 1 | Sep 19, 2019 | clinicaltrials |
| NCT04088110 | Pyrotinib Combined With Trastuzumab Plus Aromatase Inhibitor in Treatment of Breast Cancer | unknown | Phase 2 | 77 | Fuzhou General HospitalOTHER | 1 | Sep 12, 2019 | clinicaltrials |
Data updated 22 days agoSource updated Dec 18, 2024source: clinicaltrials