Cancer Family
Head and Neck Neoplasm
CI-CAN-00000021Explore in graph →
Non-malignant1,572 active trials17 approved drugs142 evidence items
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Cancer Family
CI-CAN-00000021Explore in graph →
Clinical trials
6,373 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01927744 | Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical Resection | completed | Phase 2 | 55 | M.D. Anderson Cancer CenterOTHER | 1 | Nov 26, 2025 | clinicaltrials |
| NCT05668585 | A Study to Characterize the Safety, Tolerability, and Preliminary Efficacy of CFT1946 as Monotherapy and Combination Therapy in Subjects With BRAF V600 Mutant Solid Tumors | completed | Phase 1 | 89 | C4 Therapeutics, Inc.INDUSTRY | 5 |
| Nov 21, 2025 |
| clinicaltrials |
| NCT07241611 | Role of Cervical Fascia Flap in Decreasing the Incidence of Pharyngocutaneous Fistula After Total Laryngectomy | completed | N/A | 50 | Mansoura UniversityOTHER | 1 | Nov 21, 2025 | clinicaltrials |
| NCT02918955 | Definitive Chemo-Radiotherapy for Regionally Advanced Head and Neck Cancer With or Without Up-front Neck Dissection(UPFRONT-NECK) | completed | Phase 3 | 65 | Insel Gruppe AG, University Hospital BernOTHER | 1 | Nov 20, 2025 | clinicaltrials |
| NCT04725396 | Study Comparing Fibula Free-flap MR With or Without PVP in Patients With OOPC(CURVE) | completed | N/A | 132 | UNICANCEROTHER | 1 | Nov 20, 2025 | clinicaltrials |
| NCT04454489 | Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition | completed | Phase 2 | 21 | Wake Forest University Health SciencesOTHER | 1 | Nov 19, 2025 | clinicaltrials |
| NCT07235553 | Non-inferiority Investigation to Evaluate the Efficacy and Safety of the Ultrasonic Surgical System | completed | N/A | 136 | Ezisurg Medical Co. Ltd.OTHER | 1 | Nov 19, 2025 | clinicaltrials |
| NCT02369458 | Mitomycin C in Patients With Incurable p16 Positive Oropharyngeal and p16 Negative Head and Neck Squamous Cell Carcinoma (HNSCC) Resistant to Standard Therapies | completed | Phase 2 | 48 | Washington University School of MedicineOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT02442375 | Uniform FDG-PET Guided Gradient Dose Prescription to Reduce Late Radiation Toxicity(UPGRADE-RT) | completed | Phase 3 | 300 | Radboud University Medical CenterOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT01257633 | Surgical Treatment of Early Stage Glotto-supraglottic Laryngeal Cancer Via Transoral Resection With Robotic Assistance | completed | — | 54 | Centre Hospitalier Universitaire de NīmesOTHER | 1 | Nov 17, 2025 | clinicaltrials |
| NCT04338399 | The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC(BURAN) | completed | Phase 3 | 487 | Adlai Nortye Biopharma Co., Ltd.INDUSTRY | 17 | Nov 17, 2025 | clinicaltrials |
| NCT07069153 | Laser vs Ozone Therapy for Oral Mucositis in Cancer Patients(LOMUC) | completed | N/A | 40 | University of PaviaOTHER | 1 | Nov 17, 2025 | clinicaltrials |
| NCT06129487 | Evaluations of Alcohol Warning Labels | completed | N/A | 1,053 | University of ConnecticutOTHER | 1 | Nov 14, 2025 | clinicaltrials |
| NCT03021993 | Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer | completed | Phase 2 | 17 | Medical University of South CarolinaOTHER | 1 | Nov 12, 2025 | clinicaltrials |
| NCT04463719 | AIM2: Adequate Selection of Patients for Thyroid Biopsy: Evaluation of a Shared Decision Making Conversation Aid | completed | N/A | 107 | University of FloridaOTHER | 1 | Nov 10, 2025 | clinicaltrials |
| NCT05018208 | Remote Monitoring in Cancer Care: A Platform Study | completed | — | 100 | Mayo ClinicOTHER | 1 | Oct 30, 2025 | clinicaltrials |
| NCT02882282 | Pembrolizumab in Treating Patients With High Risk Oral Intraepithelial Neoplasia | completed | Phase 2 | 15 | M.D. Anderson Cancer CenterOTHER | 1 | Oct 23, 2025 | clinicaltrials |
| NCT03894553 | Focused Ultrasound (FUS) Mesencephalotomy for Head & Neck Cancer Pain | completed | N/A | 6 | Jeff Elias, MDOTHER | 1 | Oct 23, 2025 | clinicaltrials |
| NCT03049618 | Recombinant EphB4-HSA Fusion Protein and Pembrolizumab, MK-3475 | completed | Phase 2 | 42 | University of Southern CaliforniaOTHER | 1 | Oct 22, 2025 | clinicaltrials |
| NCT06385587 | Technology-based Symptom Monitoring Intervention for Locally Advanced Head and Neck Cancer Patients(SYMTECH01) | completed | — | 33 | Aptar Digital HealthINDUSTRY | 1 | Oct 20, 2025 | clinicaltrials |
| NCT03076255 | Using a Head and Neck Maskless Immobilization Device For Patients With Intracranial Tumors | completed | N/A | 12 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson UniversityOTHER | 1 | Oct 15, 2025 | clinicaltrials |
| NCT00673010 | Lesion Dosimetry With 124-Iodine in Metastatic Thyroid Carcinoma | completed | Phase 1 | 20 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Oct 9, 2025 | clinicaltrials |
| NCT03821272 | A Phase I/II Clinical Trial of PepCan in Head and Neck Cancer Patients | completed | Phase 1 / Phase 2 | 17 | University of ArkansasOTHER | 1 | Oct 8, 2025 | clinicaltrials |
| NCT02586207 | Pembrolizumab in Combination With CRT for LA-SCCHN | completed | Phase 1 | 59 | Sanford HealthOTHER | 1 | Oct 7, 2025 | clinicaltrials |
| NCT05316974 | Lymphoedema Among Persons With Head- and Neck Cancer | completed | — | 50 | Lund UniversityOTHER | 1 | Oct 7, 2025 | clinicaltrials |
| NCT01496313 | To Compare The Effects Of Two Doses Of Vandetanib In Patients With Advanced Medullary Thyroid Cancer | completed | Phase 4 | 81 | SanofiINDUSTRY | 9 | Oct 3, 2025 | clinicaltrials |
| NCT04215978 | Safety and Preliminary Effectiveness of BGB-A445 in Combination With Tislelizumab in Participants With Advanced Solid Tumors | completed | Phase 1 | 204 | BeiGeneINDUSTRY | 8 | Oct 3, 2025 | clinicaltrials |
| NCT01644786 | The Head and Neck Tumor Biobank | completed | — | 419 | Maastricht Radiation OncologyOTHER | 1 | Oct 2, 2025 | clinicaltrials |
| NCT06199050 | The Effect of 360° Virtual Reality Movies on Fear and Anxiety(ENGAGE) | completed | N/A | 292 | Maastricht Radiation OncologyOTHER | 1 | Oct 2, 2025 | clinicaltrials |
| NCT04260126 | Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC(VERSATILE002) | completed | Phase 2 | 95 | PDS Biotechnology Corp.INDUSTRY | 4 | Oct 1, 2025 | clinicaltrials |
| NCT00765440 | Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract | completed | Phase 3 | 311 | Centre Antoine LacassagneOTHER | 1 | Sep 30, 2025 | clinicaltrials |
| NCT00875849 | Chemotherapy, Radiation Therapy, and Cetuximab in Treating Patients With the Head and Neck Cancer(AACER) | completed | Phase 2 | 53 | Centre Antoine LacassagneOTHER | 1 | Sep 30, 2025 | clinicaltrials |
| NCT05271604 | A Phase 2 Open Label Study of BA3021 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck | completed | Phase 2 | 42 | BioAtla, Inc.INDUSTRY | 1 | Sep 26, 2025 | clinicaltrials |
| NCT04417465 | First In Human Study With ABBV-CLS-579 When Given Alone and In Combination In Participants With Locally Advanced Or Metastatic Tumors | completed | Phase 1 | 101 | AbbVieINDUSTRY | 7 | Sep 25, 2025 | clinicaltrials |
| NCT00410761 | An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer | completed | Phase 3 | 331 | Genzyme, a Sanofi CompanyINDUSTRY | 24 | Sep 24, 2025 | clinicaltrials |
| NCT04979000 | HPV in Sinonasal Ca: Retrospective Analysis Association of Human Papilloma Virus (HPV) Serology and Behavioral Risk Factors | completed | — | 49 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Sep 22, 2025 | clinicaltrials |
| NCT07185542 | Function-Preserving Surgery for Parotid Tumors: Intracapsular Versus Superficial Parotidectomy; A Randomized Clinical Trial. | completed | N/A | 120 | Al-Azhar UniversityOTHER | 1 | Sep 22, 2025 | clinicaltrials |
| NCT01879384 | Monitoring of Bone Free Flaps With Microdialysis(MTM) | completed | N/A | 34 | Centre Hospitalier Universitaire, AmiensOTHER | 1 | Sep 19, 2025 | clinicaltrials |
| NCT02467738 | Surgical Resection and Intraoperative Cesium-131 Brachytherapy for Head and Neck Cancer | completed | Early Phase 1 | 30 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson UniversityOTHER | 1 | Sep 19, 2025 | clinicaltrials |
| NCT05851560 | Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid Surgery | completed | Phase 1 | 45 | National Taiwan University HospitalOTHER | 1 | Sep 19, 2025 | clinicaltrials |
| NCT04481893 | Interest of the Virtual Reality Headset in the Management of Perioperative Stress in Patients Candidates for Total Thyroidectomy(ThyroVir) | completed | N/A | 82 | Centre Francois BaclesseOTHER | 1 | Sep 18, 2025 | clinicaltrials |
| NCT03019003 | Oral Decitabine (ASTX727) and Durvalumab in Recurrent and/or Metastatic Head and Neck Cancer Patients | completed | Phase 1 | 13 | Massachusetts General HospitalOTHER | 1 | Sep 16, 2025 | clinicaltrials |
| NCT05459129 | A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer) | completed | Phase 1 / Phase 2 | 12 | Hoffmann-La RocheINDUSTRY | 3 | Sep 15, 2025 | clinicaltrials |
| NCT04057976 | Use of DTT to Define Facial Nerve Position in Vestibular Schwannomas | completed | N/A | 38 | King's College Hospital NHS TrustOTHER | 1 | Sep 12, 2025 | clinicaltrials |
| NCT04344795 | Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors | completed | Phase 1 | 89 | Tempest TherapeuticsINDUSTRY | 1 | Sep 12, 2025 | clinicaltrials |
| NCT06477341 | The Effect of Active Nutritional Support On Quality Of Life In Patients With Head And Neck Cancer Receiving Radiotherapy | completed | N/A | 47 | Assiut UniversityOTHER | 1 | Sep 12, 2025 | clinicaltrials |
| NCT06521775 | An Investigational Scan (Ga-68 PSMA-11 PET/CT) for the Detection of Therapy Response in Patients With Metastatic Adenoid Cystic Carcinoma | completed | Phase 2 | 6 | Mayo ClinicOTHER | 1 | Sep 12, 2025 | clinicaltrials |
| NCT02098538 | Regorafenib in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma | completed | Phase 2 | 38 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Sep 10, 2025 | clinicaltrials |
| NCT04800419 | RCT of Effects of Mindfulness-based Stress Reduction in Head and Neck Cancer | completed | N/A | 110 | Universiti Sains MalaysiaOTHER | 1 | Sep 10, 2025 | clinicaltrials |
Data updated 23 days agoSource updated Nov 26, 2025source: clinicaltrials