Subtype
Colorectal Adenocarcinoma
CI-CAN-00005002Explore in graph →
114 active trials1 approved drugs16 evidence items
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Subtype
CI-CAN-00005002Explore in graph →
Genomics
26 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
1,134 cases with simple somatic mutation data · 1,134 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 867 |
| 1,134 |
| 76.5% |
| cbioportal |
| 2 | TP53 | Ssm | 824 | 1,134 | 72.7% | cbioportal |
| 3 | KRAS | Ssm | 495 | 1,134 | 43.7% | cbioportal |
| 4 | PIK3CA | Ssm | 229 | 1,134 | 20.2% | cbioportal |
| 5 | SMAD4 | Ssm | 173 | 1,134 | 15.3% | cbioportal |
| 8 | TCF7L2 | Ssm | 124 | 920 | 13.5% | cbioportal |
| 6 | FBXW7 | Ssm | 145 | 1,134 | 12.8% | cbioportal |
| 7 | BRAF | Ssm | 133 | 1,134 | 11.7% | cbioportal |
| 10 | SOX9 | Ssm | 107 | 1,134 | 9.4% | cbioportal |
| 9 | KMT2D | Ssm | 107 | 1,134 | 9.4% | cbioportal |
| 11 | ARID1A | Ssm | 104 | 1,134 | 9.2% | cbioportal |
| 12 | PTPRS | Ssm | 102 | 1,134 | 9% | cbioportal |
| 13 | RNF43 | Ssm | 95 | 1,134 | 8.4% | cbioportal |
| 15 | NOTCH3 | Ssm | 85 | 1,134 | 7.5% | cbioportal |
| 14 | ATM | Ssm | 85 | 1,134 | 7.5% | cbioportal |
| 16 | CTNNB1 | Ssm | 84 | 1,134 | 7.4% | cbioportal |
| 22 | ZFHX3 | Ssm | 68 | 920 | 7.4% | cbioportal |
| 18 | PTPRT | Ssm | 78 | 1,134 | 6.9% | cbioportal |
| 17 | FAT1 | Ssm | 78 | 1,134 | 6.9% | cbioportal |
| 38 | MGA | Ssm | 57 | 920 | 6.2% | cbioportal |
| 19 | NOTCH1 | Ssm | 70 | 1,134 | 6.2% | cbioportal |
| 20 | KMT2C | Ssm | 68 | 1,134 | 6% | cbioportal |
| 21 | PTEN | Ssm | 68 | 1,134 | 6% | cbioportal |
| 24 | SMARCA4 | Ssm | 66 | 1,134 | 5.8% | cbioportal |
| 23 | EPHA5 | Ssm | 66 | 1,134 | 5.8% | cbioportal |
| 25 | AMER1 | Ssm | 65 | 1,134 | 5.7% | cbioportal |
| 26 | BRCA2 | Ssm | 65 | 1,134 | 5.7% | cbioportal |
| 27 | ERBB4 | Ssm | 64 | 1,134 | 5.6% | cbioportal |
| 29 | EP300 | Ssm | 63 | 1,134 | 5.6% | cbioportal |
| 30 | GRIN2A | Ssm | 63 | 1,134 | 5.6% | cbioportal |
Data updated 22 days agoSource updated 2026-01-16