Molecular Subtype
Chronic Myeloid Leukemia, BCR-ABL1 Positive
CI-CAN-00002365CMLExplore in graph →
Hematologic102 active trials3 approved drugs320 evidence items
- NCIt
- C3174
- OncoTree
- CMLBCRABL1
- DOID
- 0081088
- DOID
- 8552
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Molecular Subtype
CI-CAN-00002365CMLExplore in graph →
Clinical trials
649 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (104)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT05605379 | CML Pediatric ITK Response According to Molecular Identification at Diagnosis(CML Piramid) | unknown | — | 88 | University Hospital, BordeauxOTHER | 1 | Aug 14, 2024 | clinicaltrials |
| NCT02061800 | CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant | unknown | Phase 1 / Phase 2 | 14 | Diane GeorgeOTHER | 1 | Jun 4, 2024 | clinicaltrials |
| NCT03481868 | EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors(EPIK) | unknown | N/A | 160 | University Hospital, Clermont-FerrandOTHER | 1 | Apr 9, 2024 | clinicaltrials |
| NCT06233890 | The Analysis of Fatigue on Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukaemia(TIRE) | unknown | — | 50 | Imperial College Healthcare NHS TrustOTHER | 1 | Jan 31, 2024 | clinicaltrials |
| NCT04663100 | Oral Adherence in Hematological Oncology Agents and Impact on Comorbid Therapy Adherence | unknown | N/A | 30 | University of TennesseeOTHER | 1 | Dec 4, 2023 | clinicaltrials |
| NCT03193281 | KISS Study: Kinase Inhibition With Sprycel Start up(KISS) | unknown | Phase 2 | 91 | University of Auckland, New ZealandOTHER | 1 | Nov 29, 2023 | clinicaltrials |
| NCT06121765 | Metabolic Alternation and Clinicohematological Characteristic in Chronic Phase CML in Patient Treated With TKI | unknown | — | 45 | Assiut UniversityOTHER | 0 | Nov 8, 2023 | clinicaltrials |
| NCT04739826 | Flumatinib Versus Nilotinib for Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia | unknown | — | 491 | The First Affiliated Hospital of Soochow UniversityOTHER | 1 | Nov 3, 2023 | clinicaltrials |
| NCT05926128 | Study of Treatment Free Remission in Patients With Chronic Myeloid Leukemia in Chronic Phase(AST) | unknown | N/A | 75 | FundaleuOTHER | 1 | Jul 3, 2023 | clinicaltrials |
| NCT03933852 | Observational Study on Chronic Myeloid Leukemia Patients in Any Phase Treated With Ponatinib (Iclusig®) at Any Dose(Ponderosa) | unknown | — | 100 | University of JenaOTHER | 1 | May 10, 2023 | clinicaltrials |
| NCT03883087 | A Pivotal Study of HQP1351 in Patients of Chronic Myeloid Leukemia in Chronic Phase With T315I Mutation | unknown | Phase 2 | 41 | Ascentage Pharma Group Inc.INDUSTRY | 1 | Apr 3, 2023 | clinicaltrials |
| NCT03709017 | Iclusig PMS in CML or Ph+ALL Patients | unknown | — | 50 | Korea Otsuka Pharmaceutical Co., Ltd.INDUSTRY | 1 | Dec 7, 2022 | clinicaltrials |
| NCT05638763 | Cytochrome P450 Inhibition to Decrease Dosage of Dasatinib for Chronic Myelogenous Leukemia | unknown | Phase 2 | 15 | Hospital Universitario Dr. Jose E. GonzalezOTHER | 1 | Dec 6, 2022 | clinicaltrials |
| NCT05543161 | "Peripheral Blood Dipeptidylpeptidase IV (CD26) Positive Leukemic Stem Cells in Chronic Myeloid Leukemia as a Diagnostic Marker" | unknown | — | 50 | Sohag UniversityOTHER | 1 | Sep 16, 2022 | clinicaltrials |
| NCT05311943 | Treatment With Olverembatinib in CML-CP Patients Who Failed to at Least Two Previously Administered Second-generation TKIs. | unknown | Phase 3 | 40 | Shenzhen Second People's HospitalOTHER | 1 | Jul 29, 2022 | clinicaltrials |
| NCT04155411 | Dose Reduced Dasatinib (70 mg Daily) as First-line Treatment for Newly Diagnosed CML-CP | unknown | Phase 4 | 65 | Shenzhen Second People's HospitalOTHER | 1 | Jul 27, 2022 | clinicaltrials |
| NCT05353205 | A Study of the Efficacy and Safety of Flumatinib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase. | unknown | Phase 4 | 200 | Jiangsu Hansoh Pharmaceutical Co., Ltd.INDUSTRY | 1 | Apr 29, 2022 | clinicaltrials |
| NCT04835584 | KRT-232 and TKI Study in Chronic Myeloid Leukemia | unknown | Phase 1 / Phase 2 | 109 | Kartos Therapeutics, Inc.INDUSTRY | 8 | Mar 21, 2022 | clinicaltrials |
| NCT03942094 | Nilotinib for First-line Newly Diagnosed CML-CP Patients | unknown | Phase 3 | 100 | Shenzhen Second People's HospitalOTHER | 1 | Mar 16, 2022 | clinicaltrials |
| NCT04677439 | Flumatinib in CML-CP Patients With Ph+ Post Imatinib Failure | unknown | Phase 4 | 200 | Shenzhen Second People's HospitalOTHER | 1 | Mar 16, 2022 | clinicaltrials |
| NCT01752062 | Observational Study of Conception/Pregnancy in Adult Patients With CML Treated With Tyrosine Kinase Inhibitors(CML1012) | unknown | — | 148 | Gruppo Italiano Malattie EMatologiche dell'AdultoOTHER | 1 | Jan 5, 2022 | clinicaltrials |
| NCT01761890 | Front-line Treatment of BCR-ABL+ Chronic Myeloid Leukemia (CML) With Dasatinib(CML1113) | unknown | — | 147 | Gruppo Italiano Malattie EMatologiche dell'AdultoOTHER | 1 | Jan 5, 2022 | clinicaltrials |
| NCT05152537 | FLOR3 Gene Polymorphism in Predicting Outcomes of Tyrosine Kinase Inhibitor（TKI）Stopping in Chronic Myeloid Leukemia(NTU-CML-001) | unknown | — | 15 | Affiliated Hospital of Nantong UniversityOTHER | 1 | Jan 3, 2022 | clinicaltrials |
| NCT05092048 | A Study for PRO of CML in Real Word(Case-Only) | unknown | — | 10,000 | xunaOTHER | 1 | Oct 25, 2021 | clinicaltrials |
| NCT05080829 | Myeloid Mutations Register in R/R CML | unknown | N/A | 29 | Grupo Cooperativo de Hemopatías MalignasOTHER | 1 | Oct 18, 2021 | clinicaltrials |
| NCT04991532 | Dasatinib Down-regulates the Expression of PD-1 and Enhances Killing pH + Leukemia Stem Cells | unknown | — | 324 | Nanfang Hospital, Southern Medical UniversityOTHER | 1 | Aug 5, 2021 | clinicaltrials |
| NCT03795779 | CLL1-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignancies | unknown | Early Phase 1 | 20 | iCell Gene TherapeuticsINDUSTRY | 1 | May 19, 2021 | clinicaltrials |
| NCT04818619 | TIGIT in Patients With Chronic Myeloid Leukemia | unknown | — | 65 | Assiut UniversityOTHER | 0 | Mar 29, 2021 | clinicaltrials |
| NCT04709731 | Cardiovascular Assessment of Ponatinib as Third Line Treatment in Chronic Phase Chronic Myeloid Leukemia(CarPAs) | unknown | Phase 2 | 50 | Associazione Italiana Pazienti Leucemia Mieloide CronicaOTHER | 1 | Feb 3, 2021 | clinicaltrials |
| NCT02172365 | Allogeneic SCT for CML, TKI Failure After TKI Failure | unknown | — | 350 | University Health Network, TorontoOTHER | 1 | Nov 2, 2020 | clinicaltrials |
| NCT04578847 | A Study of REduction And DIscontinuation Treatment of TKI (Imatinib, Nilotinib, Dasatinib and Bosutinib)(READIT) | unknown | Phase 2 | 100 | National Research Center for Hematology, RussiaNETWORK | 1 | Oct 8, 2020 | clinicaltrials |
| NCT02381379 | Malaysia Stop Tyrosine Kinase Inhibitor Trial(MSIT) | unknown | Phase 3 | 118 | Ministry of Health, MalaysiaOTHER_GOV | 1 | Sep 14, 2020 | clinicaltrials |
| NCT01619761 | NK Cells in Cord Blood Transplantation | unknown | Phase 1 | 13 | M.D. Anderson Cancer CenterOTHER | 1 | Feb 11, 2020 | clinicaltrials |
| NCT02268370 | Treatment-free Remission Accomplished With Dasatinib in Patients With CML(TRAD) | unknown | Phase 2 | 131 | University Health Network, TorontoOTHER | 1 | Nov 29, 2019 | clinicaltrials |
| NCT04156256 | CD123-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignancies | unknown | Early Phase 1 | 20 | iCell Gene TherapeuticsINDUSTRY | 1 | Nov 12, 2019 | clinicaltrials |
| NCT04150471 | Assess Long-term Feasibility of Reduced Dose Dasatinib in Chronic Phase Chronic Myeloid Leukemia Patients | unknown | — | 79 | Seoul St. Mary's HospitalOTHER | 1 | Nov 4, 2019 | clinicaltrials |
| NCT03907670 | Chronic Myloid Leukemic Patients Treated With Tyrosine Kinase Inhibitor | unknown | — | 45 | Assiut UniversityOTHER | 0 | Sep 30, 2019 | clinicaltrials |
| NCT04104035 | Leukemic Stem Cell Detection for Chronic Myeloid Leukemia Patients With Major Molecular Response | unknown | — | 100 | Ankara UniversityOTHER | 1 | Sep 27, 2019 | clinicaltrials |
| NCT04043676 | Consolidation Treatment With Ponatinib 15 mg on Treatment Free-Remission Rate in Patients With Chronic Myeloid Leukemia | unknown | Phase 2 | 40 | Fundación Teófilo Hernando, SpainOTHER | 1 | Aug 2, 2019 | clinicaltrials |
| NCT03062436 | To Study the Impact of Stopping Therapy in Patients of CML With Molecular Remission | unknown | N/A | 27 | Command Hospital, IndiaOTHER_GOV | 1 | Jul 23, 2019 | clinicaltrials |
| NCT03075969 | Phase IV EORTC Quality of Life Module for Patients With Chronic Myeloid Leukemia | unknown | — | 337 | Gruppo Italiano Malattie EMatologiche dell'AdultoOTHER | 9 | Mar 21, 2019 | clinicaltrials |
| NCT03348033 | Safety and Feasibility of the Use of Natural Killer Cells in Patients With Chronic Myeloid Leukemia | unknown | Phase 1 / Phase 2 | 5 | Hospital de Clinicas de Porto AlegreOTHER | 1 | Mar 12, 2019 | clinicaltrials |
| NCT03625583 | The Hong Kong CML Registry | unknown | — | 200 | The University of Hong KongOTHER | 1 | Aug 10, 2018 | clinicaltrials |
| NCT02164903 | LEONIDAS: Quality of Life Study in Chronic Myeloid Leukemia Patients(QoL-CML0713) | unknown | — | 323 | Gruppo Italiano Malattie EMatologiche dell'AdultoOTHER | 4 | Aug 6, 2018 | clinicaltrials |
| NCT03573596 | Persistence of MR3 in Chronic Myeloid Leukemia (CML) After a 2nd Stop of TKI Treatment(DASTOP2) | unknown | Phase 2 | 134 | Amsterdam UMC, location VUmcOTHER | 7 | Jun 29, 2018 | clinicaltrials |
| NCT03515018 | Evaluation of the Therapeutic Effect of HU Pulse Therapy for CML Patients(HU) | unknown | Phase 3 | 60 | First Affiliated Hospital of Harbin Medical UniversityOTHER | 1 | May 22, 2018 | clinicaltrials |
| NCT03353558 | Sleep Assessment in CML(CML-SLEEP) | unknown | — | 100 | HaEmek Medical Center, IsraelOTHER | 0 | Nov 28, 2017 | clinicaltrials |
| NCT02869256 | Regional Central Database Recording of Chronic Myeloid Leukemia(LMC) | unknown | — | 400 | Institut BergoniéOTHER | 1 | Nov 21, 2017 | clinicaltrials |
| NCT03228303 | Nilotinib Versus Imatinib in Treatment of Patients With Newly Diagnosed Chronic Myeloid Leukemia | unknown | Early Phase 1 | 100 | Assiut UniversityOTHER | 0 | Oct 10, 2017 | clinicaltrials |
Data updated 22 days agoSource updated Aug 14, 2024source: clinicaltrials