Clinical trial · Observational
Leukemic Stem Cell Detection for Chronic Myeloid Leukemia Patients With Major Molecular Response
A Comparative Study of Leukemic Stem Cells in Patients With BCR-ABL-positive Hematopoiesis and Chronic Myeloid Leukemia Patients With BCR-ABL Activity Inhibition Under Tyrosine Kinase Inhibitor Treatment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Multi-Center, national, non-drug, prospective cohort study Target patient number is 100 The amount of CD45+/CD34+/CD38-/CD26+ levels of chronic myeloid leukemia (CML) stem cells in CML patients with and without BCR-ABL hematopoiesis will be compared. There will be 2 arms; 1. Patients with BCR-ABL-positive hematopoiesis 2. CML patients with BCR-ABL activity inhibition under tyrosine kinase inhibitor (TKI) therapy
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Myeloid Leukemia | Chronic Myeloid Leukemia, BCR-ABL1 Positive | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- BCR-ABL-positive hematopoiesis
- description
- Patients with BCR-ABL-positive hematopoiesis (newly diagnosed CML patients, CML patients with leukocytosis, CML patients without a hematological and/or cytogenetic and/or molecular response, CML patients whose BCR-ABL status becomes negative and then positive) will be included.
- label
- BCR-ABL activity inhibition under TKI
- description
- Patients with CML with BCR-ABL activity inhibition under TKI therapy (patients with MMR and/or deeper response) will be included.
Primary outcomes (1)
- measure
- Detection of CML leukemic stem cells in both peripheral blood and bone marrow of CML patients
- timeFrame
- 1 day
- description
- To detect the leukemic stem cells using an accurate, simple, and accessible tool in CML patients
Secondary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed CML patients or patients with a previous diagnosis under follow-up with TKIs Exclusion Criteria: \-
References
Publications (0)
Data not yet available