Clinical trial · Interventional
Study of Treatment Free Remission in Patients With Chronic Myeloid Leukemia in Chronic Phase
Prospective Study of Treatment Free Remission in Patients With Chronic Myeloid Leukemia in Chronic Phase Who Achieved Deep Molecular Response With Tyrosine Kinase Inhibitors in Real Life Setting in Argentina - (Argentine Stop Trial)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The principal aim of this study is to evaluate complete molecular remission in patients with chronic myeloid leukemia (CML) in deep molecular response after stopping tyrosine kinase inhibitor (TKI) treatment. The second aim is to characterize the immunological status of patients with CML at the time of TKI interruption and then at 3 months after the interruption.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| CML | Chronic Myeloid Leukemia, BCR-ABL1 Positive | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Discontinuing treatment with Tyrosine Kinase Inhibitor after enrolment | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- CML patient TKI discontinuation study
- description
- Treatment free remission in patients with chronic myeloid leukemia in chronic phase who achieved deep molecular response with tyrosine kinase inhibitors
- interventionNames
- Drug: Discontinuing treatment with Tyrosine Kinase Inhibitor after enrolment
Primary outcomes (1)
- measure
- Molecular relapse free survival during 24 months
- timeFrame
- 24 months
- description
- Molecular relapse free survival, defined as the time from the start of TKI interruption until the loss of the MMR. RQ PCR (IS) \>0.1% BCR ABL will be considered as loss of MMR
Secondary outcomes (1)
- measure
- Treatment-free survival during 24 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion criteria: 1. Signed Informed consent. 2. Patients with a diagnosis of CML BCR-ABL positive in CP treated with approved TKI (Imatinib, Nilotinib or Dasatinib) in 1st line or in 2nd line due to intolerance to the 1st line or in 2nd line due to the lack of deep MR with 1st line TKI, which never presented criteria for treatment failure. 3. Age ≥ 18 years 4. ≥ 4 years of treatment with imatinib, nilotinib or dasatinib. 5. Achievement of MR 4.5 in a standardized laboratory (BCR-ABL1 IS ≤ 0.0032%). 6. Evidence of MR 4.5 sustained for ≥ 2 years, as documented in at least 4 tests performed at least 3 months apart. 7. Evidence of typical quantifiable BCR-ABL1 transcript (b3a2 \[e14a2\] and / or b2a2 \[e13a2\], typical isoforms of p210). Exclusion criteria: 1. Patients who previously discontinued TKI and demonstrated recurrence of the disease. 2. Patients with failure to any TKI at any time. 3. Patients who presented accelerated phase or CML in blast crisis at any time. 4. Patients with atypical transcript not quantifiable by RT qPCR 5. BCR-ABL mutation detected at any time during the course of the resistant disease
References
Publications (0)
Data not yet available