Hematologic Malignancy
Childhood Acute Lymphoblastic Leukemia
CI-CAN-00002185Explore in graph →
PediatricHematologic67 active trials10 evidence items
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Hematologic Malignancy
CI-CAN-00002185Explore in graph →
Variants & evidence
11 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| NT5C2 Mutation1 | |||||||
| (prognostic) | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID7818Within a cohort of 71 pediatric B-ALL relapse cases, all 7 patients with NT5C2 mutations detected at relapse demonstrated early relapse (<36 months from initial diagnosis) with a median time to relaps… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC | civic |
| NT5C2 R238W3 | |||||||
| (prognostic) | Prognostic | C | Supports Poor Outcome | 2 | accepted | EID786371 Childhood B-cell acute lymphocytic leukemia relapse patients had their diagnosis and relapse samples sequenced for NT5C2 mutations. Sequencing revealed 3 early relapse cases with NT5C2 R238W enrich… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC | civic |
| Cytarabine + Doxorubicin + Gemcitabine + PrednisoloneSubstitutes | Predictive | D | Does Not Support Resistance | 4 | accepted | EID7816Overexpression of NT5C2 R238W in Reh cells resulted in no change in response to cytarabine, gemcitabine, doxorubicin or prednisolone versus wildtype or GFP controls as indicated by similar apoptosis. PMID 23377183 · Meyer et al., 2013 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | Predictive | D | Supports Resistance | ||||
| NT5C2 R367Q3 | |||||||
| Cytarabine + Doxorubicin + Gemcitabine + PrednisoloneSubstitutes | Predictive | D | Does Not Support Resistance | 4 | accepted | EID7815Lentiviral mediated overexpression of NT5C2 R367Q in Reh cells resulted in no change in apoptosis after exposure to cytarabine, gemcitabine, doxorubicin, or prednisolone compared to wildtype NT5C2 ove… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | Predictive | C | Supports Resistance | 2 | accepted | EID781271 Childhood B-cell acute lymphocytic leukemia relapse patients had their diagnosis and relapse samples sequenced for NT5C2 mutations. Sequencing revealed an early relapse case with NT5C2 R367Q enrich… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC | civic |
| 〃 | Predictive | D | |||||
| NT5C2 S445F3 | |||||||
| (prognostic) | Prognostic | C | Supports Poor Outcome | 2 | accepted | EID786471 Childhood B-cell acute lymphocytic leukemia relapse patients had their diagnosis and relapse samples sequenced for NT5C2 mutations. Sequencing revealed an early relapse case with NT5C2 S445F enrich… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC | civic |
| Cytarabine + Doxorubicin + Gemcitabine + PrednisoloneSubstitutes | Predictive | D | Does Not Support Resistance | 4 | accepted | EID7817Overexpression of NT5C2 S445F in Reh cells resulted in no change in response to cytarabine, gemcitabine, doxorubicin or prednisolone versus wildtype or GFP controls as indicated by similar apoptosis. PMID 23377183 · Meyer et al., 2013 · Open in CIViC | civic |
| Mercaptopurine + ThioguanineSubstitutes | Predictive | D | Supports Resistance | ||||
| NUDT15 Inactivating Mutation1 | |||||||
| Azathioprine + Mercaptopurine + ThioguanineSubstitutes | Predictive | B | Supports Adverse Response | 4 | submitted | EID7794Patients from three (Guatemala, Singapore and Japan) separate cohorts harboring NUDT15 loss of function mutations displayed intolerance to Thiopurine treatment (p=0.021, 2.1e-5, & 0.0054). Patients wi… (full text at CIViC) PMID 26878724 · Moriyama et al., 2016 · Open in CIViC | civic |
Data updated 10 hours agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.
| 4 |
| accepted |
EID7813Lentiviral-mediated overexpression of NT5C2 R238W in Reh cells resulted in significant resistance against thiopurines (mercaptopurine and thioguanine) versus wildtype and GFP controls, as indicated by… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC |
| civic |
| 4 |
| accepted |
EID7862Lentiviral-mediated overexpression of NT5C2 R367Q in Reh cells resulted in significant resistance against thiopurines (mercaptopurine and thioguanine) versus wildtype and GFP controls, as indicated by… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC |
| civic |
| 4 |
| accepted |
EID7814Lentiviral-mediated overexpression of NT5C2 S445F in Reh cells resulted in significant resistance against thiopurines (mercaptopurine and thioguanine) versus wildtype and GFP controls, as indicated by… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC |
| civic |