NT5C2 R367Q

CI-VAR-00003838Explore in graph →ClinVar 376349 CIViC 238

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Childhood Acute Lymphoblastic Leukemia3
NT5C2 R367Q	Cytarabine + Doxorubicin + Gemcitabine + PrednisoloneSubstitutes	Predictive	D	Does Not Support Resistance	4	accepted	EID7815 Lentiviral mediated overexpression of NT5C2 R367Q in Reh cells resulted in no change in apoptosis after exposure to cytarabine, gemcitabine, doxorubicin, or prednisolone compared to wildtype NT5C2 ove… (full text at CIViC) PMID 23377183 · Meyer et al., 2013 · Open in CIViC	civic
NT5C2 R367Q	Mercaptopurine + ThioguanineSubstitutes	Predictive	C	Supports Resistance	2	accepted	EID7812 71 Childhood B-cell acute lymphocytic leukemia relapse patients had their diagnosis and relapse samples sequenced for NT5C2 mutations. Sequencing revealed an early relapse case with NT5C2 R367Q enrich…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

T Acute Lymphoblastic Leukemia3
NT5C2 R367Q	Mercaptopurine + ThioguanineSubstitutes	Predictive	D	Supports Resistance	4	accepted	EID630 CCRF-CEM and to a lesser extent CUTLL1 T-ALL cell lines expressing the NT5C2 R367Q mutation had increased resistance to 6-mercaptopurine and 6-thioguanine treatment than cells expressing wildtype NT5C… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC	civic
NT5C2 R367Q	Arabinosylguanine + NelarabineSubstitutes	Predictive	C	Supports Sensitivity Response	4	rejected	EID634 CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT5C2 mutant proteins (R367Q, R359Q or D407A) observed in relapsed T-ALL patients showed no difference in sensitivity to nelarabine or arabinosylguanine… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC	civic
NT5C2 R367Q	Arabinosylguanine + NelarabineSubstitutes	Predictive	D	Does Not Support Resistance	4	accepted	EID633 CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT5C2 mutant proteins (K359Q, R367Q or D407A) observed in relapsed T-ALL patients showed no difference in sensitivity to nelarabine or arabinosylguanine… (full text at CIViC) PMID 23377281 · Tzoneva et al., 2013 · Open in CIViC	civic