Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin

Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

6 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–6 of 6 evidence items (6 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ROS1 Fusion1
Entrectinib	Desmoplastic Infantile AstrocytomaALIAS	Predictive	C	Supports Sensitivity Response	3	accepted	EID11850 In a phase 1/2 trial of entrectinib in pediatric patients, tumors with fusions in NTRK, ROS1, or ALK had an overall response (ORR) of 57.7% (95% CI; 36.9-76.7). This included one patient (3 yo) with … (full text at CIViC) PMID 35395680 · Desai et al., 2022 · Open in CIViC	civic
BEND2 Fusion1
(diagnostic)	Astroblastoma, MN1-Altered	Diagnostic	B	Supports Positive	4	accepted	EID8510 The authors studied tumors carrying a diagnosis of CNS primitive neuroectodermal tumors (PNETs). They identified four novel DNA methylation-defined brain tumor groups. One group, designated high-grade… (full text at CIViC) PMID 26919435 · Sturm et al., 2016 · Open in CIViC	civic
BEND2 Fusion + CXXC5 FusionCXXC5 BEND21
(diagnostic)	Astroblastoma, MN1-AlteredALIAS	Diagnostic	B	Supports Positive	3	submitted	EID12688 In a clinicopathologic and molecular series of astroblastoma (n = 8; biomarker MN1 rearrangement; primary endpoint diagnostic detection), MN1 break-apart FISH identified rearrangements in all informat… (full text at CIViC) PMID 28990708 · Hirose et al., 2018 · Open in CIViC	civic
MN1 Rearrangement3
(diagnostic)	Astroblastoma, MN1-Altered	Diagnostic	B	Supports Positive	4	accepted	EID12078 10 of 27 cases of histologically defined astroblastomas studied demonstrated an inferred MN1 rearrangement by break-apart FISH testing. Of these, all eight cases with material available for methylati… (full text at CIViC) PMID 30876455 · Lehman et al., 2019 · Open in CIViC	civic
(prognostic)	Astroblastoma, MN1-Altered	Prognostic	B	Supports Better Outcome	4	accepted	EID12079 In an analysis of 27 histologically defined astroblastomas, 10 had MN1 rearrangements, 7 had BRAF p.V600E mutations, 2 had RELA rearrangements, and 8 had none of these drivers identified. Astroblasto… (full text at CIViC) PMID 30876455 · Lehman et al., 2019 · Open in CIViC	civic
(diagnostic)	Astroblastoma, MN1-Altered	Diagnostic	B	Supports Positive	3	accepted

Data updated 18 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.