Publication
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerHigh-Grade Glioma, NOScivic_curation1.00
- cancerOligodendrogliomacivic_curation1.00
- drugAGI-5198civic_curation1.00
- geneIDH1civic_curation1.00
- variantIDH1 R132Ccivic_curation1.00
- variantIDH1 R132Hcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23558169
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| IDH1 R132C1 | ||||||||
| AGI-5198 | High-Grade Glioma, NOS | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID2329In an experimental in vitro study, glioma cells expressing IDH1 R132C were associated with sensitivity to AGI-5198 (IC50: 0.16M vs. IC50 > 100.00M), as compared to cells expressing wild-type IDH1. Sen… (full text at CIViC) PMID 23558169 · Rohle et al., 2013 · Open in CIViC | civic |
| IDH1 R132H1 | ||||||||
| AGI-5198 | OligodendrogliomaCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID979In pre-clinical studies, an IDH1 inhibitor (AG-5198) impaired growth of glioma / anaplastic oligodendroglioma cell lines with IDH1 R132H mutations. A phase I clinical trial of the AG-120 IDH1 inhibit… (full text at CIViC) PMID 23558169 · Rohle et al., 2013 · Open in CIViC | civic |