Benign Epithelial Neoplasm — Variants & evidence

Benign Epithelial Neoplasm — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items (5 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CTNNB1 Exon 3 Mutation3
(diagnostic)	Adamantinomatous CraniopharyngiomaALIAS	Diagnostic	B	Supports Positive	4	submitted	EID12111 Assessment of beta-catenin mutations in a large collections of pituitary adenomas (n=60) and craniopharynangiomas (n=41), identified CTNNB1 exon 3 mutations in 77% of craniopharynangiomas, all of the … (full text at CIViC) PMID 15891929 · Buslei et al., 2005 · Open in CIViC	civic
〃	Adamantinomatous CraniopharyngiomaALIAS	Diagnostic	B	Supports Positive	4	submitted	EID12112 Whole-exome sequencing identified CTNNB1 mutations in 11 of 12 (92%) of adamantinomatous craniopharyngiomas examined. No other recurrent mutations or genomic aberrations were identified. Targeted se… (full text at CIViC) PMID 24413733 · Brastianos et al., 2014 · Open in CIViC	civic
〃	Adamantinomatous CraniopharyngiomaALIAS	Diagnostic	B	Supports Positive	4	submitted	EID12113 CTNNB1 sequencing a cohort of 80 adamantinomatous craniopharyngiomas and 35 papillary craniopharyngiomas identified CTNNB1 activating mutations exclusively in the adamantinomatous subtype (in 79 or 8… (full text at CIViC) PMID 26927026 · Hölsken et al., 2016 · Open in CIViC	civic
CTNNB1 I35T + FBXW11 F517SFBXW11 CTNNB11
(diagnostic)	Basal Cell AdenomaALIAS	Diagnostic	B	Supports Positive	4	submitted	EID12637 A comprehensive molecular profiling (whole exome and whole transcriptome sequencing) determined that CTNNB1 I35T and FBXW11 F517S missense mutations were mutually exclusive and collectively account fo… (full text at CIViC) PMID 40389436 · Wong et al., 2025 · Open in CIViC	civic
PLAG1 Fusion1
(diagnostic)	Skin Mixed TumorALIAS	Diagnostic	B	Supports Positive	4	submitted	EID13224 In a molecular analysis comparing 46 apocrine cutaneous mixed tumors (CMTs) with 45 salivary gland pleomorphic adenomas (PAs), TRPS1::PLAG1 was the predominant PLAG1 fusion in CMTs and was significant… (full text at CIViC) PMID 39468990 · Alsugair et al., 2024 · Open in CIViC	civic

Data updated 6 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.