Cancer Family
B-Cell Malignant Neoplasm
CI-CAN-00000070Explore in graph →
Hematologic2,083 active trials46 approved drugs301 evidence items
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Cancer Family
CI-CAN-00000070Explore in graph →
Genomics
29 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
755 cases with simple somatic mutation data · 760 cases total · 2026-01-08 · mapped to B-Cell Non-Hodgkin Lymphoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KMT2D |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 247 |
| 755 |
| 32.7% |
| cbioportal |
| 2 | CREBBP | Ssm | 180 | 755 | 23.8% | cbioportal |
| 3 | BCL2 | Ssm | 153 | 755 | 20.3% | cbioportal |
| 4 | NEB | Ssm | 123 | 755 | 16.3% | cbioportal |
| 5 | ATM | Ssm | 116 | 755 | 15.4% | cbioportal |
| 6 | LRP1B | Ssm | 96 | 755 | 12.7% | cbioportal |
| 7 | TP53 | Ssm | 91 | 755 | 12.1% | cbioportal |
| 8 | MYC | Ssm | 82 | 755 | 10.9% | cbioportal |
| 9 | ARID1A | Ssm | 80 | 755 | 10.6% | cbioportal |
| 10 | HERC2 | Ssm | 78 | 755 | 10.3% | cbioportal |
| 11 | TNFRSF14 | Ssm | 77 | 755 | 10.2% | cbioportal |
| 12 | CSMD1 | Ssm | 70 | 755 | 9.3% | cbioportal |
| 13 | CSMD3 | Ssm | 69 | 755 | 9.1% | cbioportal |
| 14 | PIM1 | Ssm | 66 | 755 | 8.7% | cbioportal |
| 15 | FAT1 | Ssm | 65 | 755 | 8.6% | cbioportal |
| 16 | EZH2 | Ssm | 64 | 755 | 8.5% | cbioportal |
| 17 | RYR2 | Ssm | 64 | 755 | 8.5% | cbioportal |
| 18 | PIEZO1 | Ssm | 63 | 755 | 8.3% | cbioportal |
| 19 | CARD11 | Ssm | 62 | 755 | 8.2% | cbioportal |
| 20 | IGLV5-45 | Ssm | 58 | 755 | 7.7% | cbioportal |
| 23 | HMCN1 | Ssm | 56 | 755 | 7.4% | cbioportal |
| 21 | CCND3 | Ssm | 56 | 755 | 7.4% | cbioportal |
| 22 | EP300 | Ssm | 56 | 755 | 7.4% | cbioportal |
| 24 | SMARCA4 | Ssm | 55 | 755 | 7.3% | cbioportal |
| 26 | RYR3 | Ssm | 54 | 755 | 7.2% | cbioportal |
| 25 | HYDIN | Ssm | 54 | 755 | 7.2% | cbioportal |
| 28 | DST | Ssm | 53 | 755 | 7% | cbioportal |
| 27 | DCHS2 | Ssm | 53 | 755 | 7% | cbioportal |
| 29 | BCL7A | Ssm | 52 | 755 | 6.9% | cbioportal |
| 32 | H1-4 | Ssm | 52 | 755 | 6.9% | cbioportal |
Data updated 22 days agoSource updated 2026-01-08