Alveolar Soft Part Sarcoma — Variants & evidence

Alveolar Soft Part Sarcoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TFE3 Fusion4
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID9978 Alveolar soft part sarcoma (ASPS) is characterized by the presence of an unbalanced translocation der(17)t(X;17)(p11;q25). In this 2001 paper, FISH with YAC and cosmid probes was used to localize the… (full text at CIViC) PMID 11244503 · Ladanyi et al., 2001 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID11530 In this 2012 paper, the authors assessed potential characteristic markers in 24 alveolar soft part sarcoma (ASPS cases), age range from 13 to 61 years, and 23 non-ASPS tumors. Nuclear immunoreactivity… (full text at CIViC) PMID 21835426 · Tsuji et al., 2012 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID11531 This study by Ju, et al. (2018) consisted of nine cases of alveolar soft part sarcoma (ASPS). The age of patients ranged from 7 to 36 years. Total mRNA was extracted from seven of the nine ASPS paraff… (full text at CIViC) PMID 28766250 · Ju et al., 2018 · Open in CIViC	civic
(oncogenic)	Oncogenic	D	Supports Oncogenicity	4	accepted	EID9883 Goodwin, et al. (2014) presented in vivo study on mice carrying the ASPSCR1-TFE3 fusion gene. The results showed that Rosa26-LSL-AT3/CreER mice expressed tumors histological equal to the human’s alveo… (full text at CIViC) PMID 25453902 · Goodwin et al., 2014 · Open in CIViC	civic

Data updated 6 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.