TFE3 Fusion

CI-VAR-00001322Explore in graph →CIViC 3622

Curated evidence

Evidence by cancer (7 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–7 of 7 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Alveolar Soft Part Sarcoma4
ASPSCR1::TFE3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID9978 Alveolar soft part sarcoma (ASPS) is characterized by the presence of an unbalanced translocation der(17)t(X;17)(p11;q25). In this 2001 paper, FISH with YAC and cosmid probes was used to localize the… (full text at CIViC) PMID 11244503 · Ladanyi et al., 2001 · Open in CIViC	civic
ASPSCR1::TFE3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID11530 In this 2012 paper, the authors assessed potential characteristic markers in 24 alveolar soft part sarcoma (ASPS cases), age range from 13 to 61 years, and 23 non-ASPS tumors. Nuclear immunoreactivity… (full text at CIViC) PMID 21835426 · Tsuji et al., 2012 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Renal Cell Carcinoma with MiT Translocations2
ASPSCR1::TFE3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	rejected	EID11529 Argani, et al. (2001) included eight morphologically distinctive renal cell carcinomas with the t(X;17) translocation as seen in alveolar soft part sarcoma (ASPS), with the distinction that the t(X;17… (full text at CIViC) PMID 28766250 · Ju et al., 2018 · Open in CIViC	civic
ASPSCR1::TFE3 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID11532 Argani, et al. (2001) included eight morphologically distinctive renal cell carcinomas with the t(X;17) translocation as seen in alveolar soft part sarcoma (ASPS), with the distinction that the t(X;17… (full text at CIViC) PMID 11438465 · Argani et al., 2001 · Open in CIViC	civic

Sarcoma1
ASPSCR1::TFE3 Fusion	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9884 Ishiguro, et al. (2016) presented in vitro functional study on different cell lines. The ASPSCR1-TFE3 (here referred to as ASPL-TFE3) fusion gene induction of expression resulted in cell cycle arrest … (full text at CIViC) PMID 27673450 · Ishiguro et al., 2016 · Open in CIViC	civic