Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3); KAT6A-CREBBP

Acute Myeloid Leukemia with t(8;16)(p11.2;p13.3); KAT6A-CREBBP — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CREBBP Fusion3
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12153 This is an international retrospective study by International Berlin-Frankfurt-Munster (I-BFM) AML study group including 543 pediatric AML patients from 18 countries diagnosed between 1995-2005. The a… (full text at CIViC) PMID 23974201 · Coenen et al., 2013 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID12154 This manuscript is the first report of a unique expression profile in pediatric AML with KAT6A::CREBBP gene fusion (known also as MOZ::CBP or MYST3::CREBBP). Genomic studies and gene expression profil… (full text at CIViC) PMID 20630590 · Serravalle et al., 2010 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	3	accepted	EID12155 The authors reported a congenital AML case with leukemia cutis and a cryptic insertional t(8;16)(p11.2;p13.3)/KAT6A::CREBBP fusion identified exclusively by FISH. They found KAT6A::CREBBP fusion in 11… (full text at CIViC) PMID 28097792 · Barrett et al., 2017 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.