Hematologic Malignancy
Acute Lymphoblastic Leukemia
CI-CAN-00000400ALLExplore in graph →
Hematologic547 active trials12 approved drugs43 evidence items
- NCIt
- C3167
- DOID
- 9952
- MeSH
- D054198
- Other
- 3 more codes
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Hematologic Malignancy
CI-CAN-00000400ALLExplore in graph →
Genomics
3 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
768 cases with simple somatic mutation data · 1,587 cases total · Data Release 46.0 · mapped to Acute Lymphoblastic Leukemia ONTOLOGY_EXACT
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PRSS1 | Ssm | 219 | 768 | 28.5% | gdc |
| 2 | PRSS2 | Ssm | 218 | 768 | 28.4% | gdc |
| 4 | CDKN2A | Ssm | 209 | 768 | 27.2% | gdc |
| 3 | MTRNR2L6 | Ssm | 209 | 768 | 27.2% | gdc |
| 6 | AL359922.1 | Ssm | 183 | 768 | 23.8% | gdc |
| 5 | CDKN2B | Ssm | 183 | 768 | 23.8% | gdc |
| 7 | MTAP | Ssm | 170 | 768 | 22.1% | gdc |
| 8 | NOTCH1 | Ssm |
Data updated 22 days agoSource updated Data Release 46.0
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 163 |
| 768 |
| 21.2% |
| gdc |
| 9 | DMRTA1 | Ssm | 126 | 768 | 16.4% | gdc |
| 10 | IFNE | Ssm | 111 | 768 | 14.5% | gdc |
| 11 | IFNA8 | Ssm | 108 | 768 | 14.1% | gdc |
| 12 | IFNA1 | Ssm | 108 | 768 | 14.1% | gdc |
| 14 | IFNA6 | Ssm | 106 | 768 | 13.8% | gdc |
| 13 | IFNA2 | Ssm | 106 | 768 | 13.8% | gdc |
| 15 | IFNA13 | Ssm | 105 | 768 | 13.7% | gdc |
| 16 | KLHL9 | Ssm | 103 | 768 | 13.4% | gdc |
| 17 | IFNA5 | Ssm | 103 | 768 | 13.4% | gdc |
| 19 | IFNA16 | Ssm | 99 | 768 | 12.9% | gdc |
| 18 | IFNA17 | Ssm | 99 | 768 | 12.9% | gdc |
| 20 | IFNA10 | Ssm | 98 | 768 | 12.8% | gdc |
| 21 | IFNA7 | Ssm | 98 | 768 | 12.8% | gdc |
| 22 | IFNA14 | Ssm | 98 | 768 | 12.8% | gdc |
| 23 | KRAS | Ssm | 97 | 768 | 12.6% | gdc |
| 24 | IFNA4 | Ssm | 96 | 768 | 12.5% | gdc |
| 25 | IFNA21 | Ssm | 95 | 768 | 12.4% | gdc |
| 26 | IFNW1 | Ssm | 93 | 768 | 12.1% | gdc |
| 27 | IFNB1 | Ssm | 90 | 768 | 11.7% | gdc |
| 28 | HACD4 | Ssm | 86 | 768 | 11.2% | gdc |
| 29 | NRAS | Ssm | 85 | 768 | 11.1% | gdc |
| 30 | ELAVL2 | Ssm | 77 | 768 | 10% | gdc |