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Variants & evidence
6 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| Deletion1 | |||||||
| (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID12836Microarray-based comparative genomic hybridization (aCGH) analysis was carried out on 58 Wilms’ tumor samples. 38 tumors were untreated primary and 20 were recurrent. An increase in copy number change… (full text at CIViC) PMID 17103382 · Natrajan et al., 2007 · Open in CIViC | civic |
| Amplification1 | |||||||
| (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID1283777 tumors from Wilms Tumor patients were tested with Illumina BeadChip arrays and genomic profiles were tested for association with relapse and other clinicopathological variables. Copy number gain at… (full text at CIViC) PMID 22407497 · Perotti et al., 2012 · Open in CIViC | civic |
| Deletion1 | |||||||
| (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID12834Anaplastic histology (AH) in Wilm's Tumor is characterized by abnormal mitoses, and associated with poor prognosis in comparison to favorable histology (FH). Array CGH was used on 53 AH samples, and a… (full text at CIViC) PMID 21882282 · Williams et al., 2011 · Open in CIViC | civic |
| DROSHA E518K1 | |||||||
| (prognostic) | Prognostic | B | Supports Poor Outcome | 4 | submitted | EID6090A higher relapse rate was observed in patients that have both DROSHA E518K and SIX Q177R muations. PMID 25670082 · Walz et al., 2015 · Open in CIViC | civic |
| Deletion + TP53 Mutation1 | |||||||
| (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID1283540 diffuse anaplasia in Wilms tumours (DAWT) samples were tested using copy number (n = 32) and gene expression (n = 36) arrays. 22 had TP53 mutations and 20 of these also had 17p loss. An increased r… (full text at CIViC) PMID 25313908 · Maschietto et al., 2014 · Open in CIViC | civic |
| TP53 Overexpression1 | |||||||
| (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID894544 archival FFPE samples from confirmed cases of Wilms tumor with mean age 3 years 2 months, and taken from the most histologically aggressive parts of each tumor, were stained with p53 monoclonal ant… (full text at CIViC) PMID 21525573 · Jadali et al., 2011 · Open in CIViC | civic |
Data updated 22 hours agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.