Molecular Subtype
NTRK-Rearranged Spindle Cell Neoplasm
CI-CAN-00003444Explore in graph →
Non-malignant1 active trials7 evidence items
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Molecular Subtype
CI-CAN-00003444Explore in graph →
Variants & evidence
8 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| NTRK1 Fusion5 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 4 | accepted | EID6391A 14-month-old boy presented with a slow-growing, asymptomatic back plaque, which was biopsied and found to have S100 positivity, sparse CD34 staining, and no significant mitotic activity, nuclear ple… (full text at CIViC) PMID 29892662 · Bartenstein et al., 2018 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID11576A 31-year-old female presented with a pigmented nodule on her scalp that enlarged in size over a 2-year period. Biopsy demonstrated a fascicular proliferation of bland spindle cells within the dermis … (full text at CIViC) PMID 32519338 · Panse et al., 2021 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID11577A 21-year-old man demonstrated intermittent abdominal pain, and a CT scan revealed an abnormal paraspinal lesion. Biopsy revealed a spindle cell mesenchymal tumor with monotonous, bland spindle cells … (full text at CIViC) PMID 32782782 · Dupuis et al., 2020 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID11650A 3-year-old girl presented with spots on her right buttock that evolved into lumps. Magnetic resonance imaging showed diffuse subcutaneous tissue thickening without significant involvement of underly… (full text at CIViC) PMID 32299759 · Malik et al., 2020 · Open in CIViC | civic |
| Entrectinib | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID11578A 21-year-old man demonstrated intermittent abdominal pain, and a CT scan revealed an abnormal paraspinal lesion. IHC was positive for CD34, S-100, and pan-TRK and negative for Sox10. Anchored multip… (full text at CIViC) PMID 32782782 · Dupuis et al., 2020 · Open in CIViC | civic |
| NTRK1 Fusion + S100B ExpressionNTRK1S100B1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 2 | submitted | EID12006Among pediatric fibroblastic and myofibroblastic proliferating superficial lesions, lipofibromatosis (LPF), composed of an admixture of adipose tissue and fibroblastic elements, has been variously cla… (full text at CIViC) PMID 27259011 · Agaram et al., 2016 · Open in CIViC | civic |
| NTRK1 Fusion1 | |||||||
| (oncogenic) | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID11704An intra-chromosomal TPR::NTRK1 fusion was found in a superficial soft tissue tumor located on the hand of a 7-year-old girl. The tumor had a prominently infiltrative growth pattern reminiscent of lip… (full text at CIViC) PMID 27259011 · Agaram et al., 2016 · Open in CIViC | civic |
| NTRK1 Fusion1 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 3 | accepted | EID7293Among pediatric fibroblastic and myofibroblastic proliferating superficial lesions, lipofibromatosis (LPF), composed of an admixture of adipose tissue and fibroblastic elements, has been variously cla… (full text at CIViC) PMID 27259011 · Agaram et al., 2016 · Open in CIViC | civic |
Data updated 20 minutes agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.