Spitzoid Melanoma — Variants & evidence

Spitzoid Melanoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

2 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NTRK1 Fusion2
(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID8904 A total of 140 Spitzoid neoplasm cases were analyzed by FISH and/or targeted DNA and RNA sequencing (n=38). Mutually exclusive kinase fusions were found in 72 cases. NTRK1 fusions were observed in 23 … (full text at CIViC) PMID 24445538 · Wiesner et al., 2014 · Open in CIViC	civic
(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	accepted	EID8903 The in-frame LMNA-NTRK1 fusion (exon 2 & exon 11) with intact kinase domain was found and confirmed by next generation sequencing, RT-PCR, FISH, and/or immunohistochemistry in 3 Spitz neoplasm cases. … (full text at CIViC) PMID 24445538 · Wiesner et al., 2014 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.