Variant · Splice
CD44 CD44v6
CI-VAR-00000375Explore in graph →CIViC 3373
Curated evidence
Evidence by cancer (10 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25887688
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Hepatocellular Carcinoma1 | ||||||||
| CD44 CD44v6 | (prognostic) | Prognostic | B | Supports Poor Outcome | 5 | submitted | EID9407In a meta-analysis including nine trials with a total of 942 patients, high CD44v6 expression is significantly associated with a decrease in survival outcome (HR 2.13, 95% CI: 1.58 to 2.88). PMID 25887688 · Fu et al., 2015 · Open in CIViC | civic |
| Malignant Cervical Neoplasm1 | ||||||||
| CD44 CD44v6 | Cisplatin | Predictive | B | Supports Resistance | 4 | submitted | EID9481In a clinical trial including 21 patients, CD44v6 expression (prior to and after to NAC) is a predictive factor of response to NAC by multivariate analysis (p = 0.0099 and p = 0.0470). Moreover, CD44v… (full text at CIViC) PMID 11136572 · Costa et al., 2001 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available