Multinodular and Vacuolated Neuronal Tumor — Variants & evidence

Multinodular and Vacuolated Neuronal Tumor — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BRAF G469S1
(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID12460 In an 11-year-old female presenting with seizures, a mixed MVNT with a ganglioglioma-like component located in the left temporal lobe revealed a BRAF p.G469S mutation (NM_004333.6:c.1405_1406delinsTC;… (full text at CIViC) PMID 29428973 · Pekmezci et al., 2018 · Open in CIViC	civic
BRAF L597R1
(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID12459 In a 54-year-old female with chronic headache and a right temporal lobe MVNT, NGS (479-gene panel) identified a BRAF p.L597R mutation (NM_004333.6:c.1790T>G; VAF 5%). PMID 29428973 · Pekmezci et al., 2018 · Open in CIViC	civic
BRAF Mutation + FGFR2 Fusion + MAP2K1 MutationBRAF FGFR2 MAP2K11
(diagnostic)	Diagnostic	C	Supports Positive	3	submitted	EID12458 Eight MVNT cases (6 pure MVNT and 2 with ganglioglioma-like features) were examined, comprising 4 males and 4 females aged 11–63 years (median 39). Tumors were localized to the temporal lobe (n=7) or … (full text at CIViC) PMID 29428973 · Pekmezci et al., 2018 · Open in CIViC	civic
MAP2K1 Q56_G61delinsL1
(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID12462 A 43-year-old male with chronic headache was found to have a left frontal multinodular and vacuolating neuronal tumor (MVNT). NGS targeting 479 cancer-associated genes identified a MAP2K1 in-frame ind… (full text at CIViC) PMID 29428973 · Pekmezci et al., 2018 · Open in CIViC	civic
MAP2K1 Q56P1
(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID12461 NGS targeting 479 cancer-associated genes were performed on two MVNT cases: a 63-year-old female with left-hand paresthesia and a 54-year-old male with long-standing epilepsy, both located in the righ… (full text at CIViC) PMID 29428973 · Pekmezci et al., 2018 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.