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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,127 stopped studies mapped to Secondary Malignant Neoplasm and descendants · 91% state a reason
Over the 2,127 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00838968 | The Efficiency of Postoperative Interferon-alpha Treatment in p48 Positive Patients With… | N/A | withdrawn | Feb 9, 2009 | Fudan University | we have found another marker (microRNA26) which is more sensitive to evaluate the effect of… | Other (stated, no rule matched) |
| NCT01563601 | Efficacy and Safety of Obatoclax Mesylate in Combination With Carboplatin and Etoposide… | Phase 3 | withdrawn | Mar 27, 2012 | Cephalon | Business Decision | Sponsor / business decision |
| NCT00038038 | Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole | N/A | withdrawn | May 27, 2002 | M.D. Anderson Cancer Center | No participants enrolled, study terminated. | Enrollment / accrual |
| NCT00426829 | Proton Therapy and Bevacizumab for Primary Liver Tumors | Phase 1 | terminated | Jan 25, 2007 | M.D. Anderson Cancer Center | Low Accural | Other (stated, no rule matched) |
| NCT01070186 | Study of Sunitinib in Subjects With High Risk Renal Cell Carcinoma | Phase 2 | withdrawn | Feb 17, 2010 | Jonsson Comprehensive Cancer Center | No participants were enrolled. | Enrollment / accrual |
| NCT00605709 | Dose-Ranging Safety and Efficacy Study of Topical Creams Containing API 31510 for the… | Phase 2 | withdrawn | Jan 31, 2008 | BPGbio | not stated | Not stated |
| NCT00368329 | Phase I Dose Escalation of Stereotactic Radiosurgical Boost for Locally Advanced… | Phase 1 | terminated | Aug 24, 2006 | Stanford University | low accrual | Enrollment / accrual |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00562666 | Immunotherapy of Hepatocellular Carcinoma With Gamma Delta T Cells(ICAR) | Phase 1 | terminated | Nov 22, 2007 | Rennes University Hospital | not stated | Not stated |
| NCT01327521 | Transarterial Chemoembolization vs CyberKnife for Recurrent Hepatocellular Carcinoma | Phase 3 | withdrawn | Apr 1, 2011 | Albert Koong | Accrual below target levels | Enrollment / accrual |
| NCT00324558 | Adjuvant BEmiparin in Small Cell Lung Carcinoma (ABEL STUDY) | Phase 2 | terminated | May 11, 2006 | Clinica Universidad de Navarra, Universidad de Navarra | Sponsor stopped due to difficulties to recruit 130 patients required by protocol | Enrollment / accrual |
| NCT00618384 | TACE and Sorafenib for Advanced Hepatocellular Carcinoma (HCC)(SOCRATES) | Phase 2 | terminated | Feb 20, 2008 | Heinrich-Heine University, Duesseldorf | not stated | Not stated |
| NCT01491139 | Phase I Study of Olaparib With Cisplatin Based Chemoradiotherapy in Squamous Cell…(ORCA) | Phase 1 | withdrawn | Dec 13, 2011 | University College, London | Study stopped due to issues surrounding development and formulation of olaparib | Other (stated, no rule matched) |
| NCT00466856 | Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine… | Phase 2 | terminated | Apr 27, 2007 | Vanderbilt-Ingram Cancer Center | due to slow accrual | Enrollment / accrual |
| NCT00311467 | Combined Treatment With Capecitabine and Immunotherapy Versus Immunotherapy Alone in… | Phase 3 | terminated | Apr 6, 2006 | Central European Cooperative Oncology Group | no patient recruitment | Enrollment / accrual |
| NCT00100685 | Study of M200 (Volociximab) in Patients With Metastatic Renal Cell Carcinoma (RCC) | Phase 2 | terminated | Jan 5, 2005 | Abbott | not stated | Not stated |
| NCT01033981 | Cost Effectiveness Of Sunitinib In Central America And Caribbean | — | terminated | Dec 17, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01194206 | Stereotactic Body Radiation Therapy in Liver Cancer That Cannot be Removed by Surgery or… | Phase 2 | withdrawn | Sep 2, 2010 | Case Comprehensive Cancer Center | Study being rewritten | Other (stated, no rule matched) |
| NCT01075607 | Lymph Fluid and Blood Collection for Identification of Novel Biomarkers | — | terminated | Feb 25, 2010 | Indiana University | Halted prematurely due to lack of funding. | Funding |
| NCT01337492 | Pilot Study Sorafenib as Bridge to Orthotopic Liver Transplantation (OLT) | Early Phase 1 | terminated | Apr 19, 2011 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00485563 | A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive… | Phase 2 | terminated | Jun 13, 2007 | Endocyte | Changes in treatment paradigm resulted in a lower than expected rate of accrual. | Enrollment / accrual |
| NCT00151671 | Effect of a Perioperative Oral Nutritional Supplementation on Patients Undergoing Hepatic…(IMPACT) | Phase 2 / Phase 3 | terminated | Sep 9, 2005 | Rennes University Hospital | insufficient enrollment rate | Enrollment / accrual |
| NCT01318200 | Transarterial Chemoembolization (TACE) vs. CyberKnife for Recurrent Hepatocellular… | Phase 3 | withdrawn | Mar 18, 2011 | Accuray Incorporated | not stated | Not stated |
| NCT00472771 | INNO-206 in Patients With Small Cell Lung Cancer (SCLC) | Phase 2 | withdrawn | May 14, 2007 | CytRx | Terminated due to clinical trial material production delays | Other (stated, no rule matched) |
| NCT00363441 | A Study of Conventional 3D Radiation vs. Intensity-Modulated Radiation in Squamous Cell… | Phase 2 / Phase 3 | withdrawn | Aug 15, 2006 | Alberta Health services | not stated | Not stated |
| NCT00561912 | Low Dose Decitabine + Interferon Alfa-2b in Advanced Renal Cell Carcinoma | Phase 2 | terminated | Nov 21, 2007 | M.D. Anderson Cancer Center | Low accrual. | Enrollment / accrual |
| NCT00401401 | Zalutumumab in Combination With Chemotherapy and Radiotherapy in Head and Neck Cancer | Phase 1 / Phase 2 | terminated | Nov 20, 2006 | Genmab | MTD was established and patients completed 16 months safety f-up and response assessments. It is… | Safety / toxicity |
| NCT01441388 | A Study Of Crizotinib Plus VEGF Inhibitor Combinations In Patients With Advanced Solid… | Phase 1 | withdrawn | Sep 27, 2011 | Pfizer | Business/Operational issues | Sponsor / business decision |
| NCT01100489 | Breast-Conserving Surgery Followed by Radiation Therapy With MRI-Detected Stage I or… | Phase 2 | withdrawn | Apr 9, 2010 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
| NCT00593008 | Temsirolimus in Combination With Gemcitabine in Previously Untreated Metastatic… | Phase 1 | terminated | Jan 14, 2008 | Massachusetts General Hospital | not stated | Not stated |
| NCT00937300 | T-cell Based Immunotherapy for Head and Neck Cancer | Phase 1 | withdrawn | Jul 13, 2009 | Inge Marie Svane | The patients eligible for this trial do not exist anymore due to change in procedures. | Other (stated, no rule matched) |
| NCT01245582 | Oxaliplatin and Capecitabine on Top of Sorafenib Versus Sorafenib Alone in Advanced…(SECOX) | Phase 3 | withdrawn | Nov 22, 2010 | Sanofi | not stated | Not stated |
| NCT00225290 | Phase III Trial of Oral Thalidomide in Advanced Hepatocellular Carcinoma With Poor Liver… | Phase 3 | terminated | Sep 23, 2005 | TTY Biopharm | slowly recruitment rate | Enrollment / accrual |
| NCT00732745 | Vandetanib, Oxaliplatin, and Docetaxel in Advanced Cancer of the Esophagus or… | Phase 1 | terminated | Aug 12, 2008 | Case Comprehensive Cancer Center | Lost funding for Phase II portion of study | Funding |
| NCT00805012 | Docetaxel and S-1 in Head and Neck Squamous Cell Carcinoma (HNSCC) | Phase 2 | terminated | Dec 9, 2008 | Seoul National University Hospital | slow accrual rate | Enrollment / accrual |
| NCT00112619 | Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia,… | Phase 1 | terminated | Jun 3, 2005 | Pediatric Brain Tumor Consortium | Slow accrual and company withdrawing support to supply the drug | Drug supply |
| NCT00563862 | Benefit of Adding Chemotherapy And/Or Modification of Radiotherapy Schedule for Advance… | N/A | terminated | Nov 26, 2007 | Hospital Authority, Hong Kong | not stated | Not stated |
| NCT00568308 | Phase III Study of PI-88 in Post-resection Hepatocellular Carcinoma(PATHWAY) | Phase 3 | terminated | Dec 6, 2007 | Progen Pharmaceuticals | Commercial decision to discontinue the study | Other (stated, no rule matched) |
| NCT01363466 | Evaluation of Hysterectomy After Chemoradiation Therapy for Stage IB2/II Cervical Cancer | Phase 3 | terminated | Jun 1, 2011 | UNICANCER | low recruitment | Enrollment / accrual |
| NCT01077869 | A Feasibility Study on the Use of F-18-FDG-PET and Optical Imaging in Evaluation of… | — | terminated | Mar 1, 2010 | University Hospital, Ghent | poor recruitment rate | Enrollment / accrual |
| NCT00470340 | Chemotherapy or Not, Following Complete Treatment of Hepatic Cancer in Cirrhotic Patients(GEMOXIAL) | Phase 3 | terminated | May 7, 2007 | Assistance Publique - Hôpitaux de Paris | during the study | Other (stated, no rule matched) |
| NCT00216216 | Pemetrexed in Patients With Chemosensitive and Chemoresistant Relapsed Small Cell Lung… | Phase 2 | terminated | Sep 22, 2005 | Hoosier Cancer Research Network | The results from the interim analysis were not favorable to continue this trial. | Efficacy / futility |
| NCT00117351 | VELCADE in Previously Treated Patients With Stage IIIB and IV Bronchioloalveolar… | Phase 2 | terminated | Jul 6, 2005 | Millennium Pharmaceuticals, Inc. | insufficient efficacy | Efficacy / futility |
| NCT00233636 | Iressa and Radiotherapy in the Treatment of the Locally Advanced Inoperable Squamous Cell… | Phase 2 | withdrawn | Oct 6, 2005 | AstraZeneca | not stated | Not stated |
| NCT00065572 | Exploratory Study to Assess the Biological Activity of ZD6126 in Subjects With Newly… | Phase 2 | suspended | Jul 31, 2003 | AstraZeneca | not stated | Not stated |
| NCT00428597 | A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell… | Phase 3 | terminated | Jan 30, 2007 | Pfizer | Refer to Detailed Description. | Other (stated, no rule matched) |
| NCT00472706 | Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease | Phase 4 | terminated | May 14, 2007 | Catharina Ziekenhuis Eindhoven | Study stopped because of disappointing inclusion rates | Other (stated, no rule matched) |
| NCT00280007 | Transarterial Chemoembolisation Plus Bevacizumab for Treatment of Hepatocellular Carcinoma | Phase 2 | terminated | Jan 20, 2006 | Medical University of Vienna | Safety concerns in the treatment arm | Safety / toxicity |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00277316 | Study of XL999 in Patients With Metastatic Renal Cell Carcinoma | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Development of XL999 was stopped due to cardiac toxicities in the subjects | Safety / toxicity |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 23, 2012source: clinicaltrials