Clinical trial · Interventional
Phase III Trial of Oral Thalidomide in Advanced Hepatocellular Carcinoma With Poor Liver Reserve
Double-blind, Placebo-controlled, Randomized Phase III Trial of Oral Thalidomide in Advanced Hepatocellular Carcinoma With Poor Liver Reserve
NCT00225290CI-TRIAL-00005621terminatedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): slowly recruitment rate
Summary
Brief summary (as posted)
To compare the overall survival of thalidomide- and placebo-treated advanced HCC patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Hepatocellular | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Thalidomide(Thado) | Drug | Thalidomide | ALIAS |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- overall survival
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with measurable, metastatic or locally advanced hepatocellular carcinoma 2. The diagnosis of HCC should be established either by cyto/histology 3. Patients must be \> 20 years of age. 4. ECOG score \< 2. 5. Signed informed consent. 6. Female patients at child-bearing age must have negative pregnancy test. Exclusion Criteria: 1. Patients with other systemic diseases which require concurrent usage of glucocorticosteroid or immunosuppressant agent(s) are not eligible. 2. Patients with advanced second primary malignancy are not eligible. 3. Patients with active infection are not eligible. 4. Patients with pregnancy or breast-feeding are not eligible. 5. Patients with brain metastases are not eligible.
References
Publications (0)
Data not yet available
No reference posted for this study.