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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,127 stopped studies mapped to Secondary Malignant Neoplasm and descendants · 91% state a reason
Over the 2,127 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00697476 | Study of Oral Vorinostat in Combination With Topotecan in Patients With Chemosensitive… | Phase 1 / Phase 2 | terminated | Jun 13, 2008 | Armando Santoro, MD | insufficient enrollment | Enrollment / accrual |
| NCT01219907 | Ex Vivo-Expanded HER2-Specific T Cells and Cyclophosphamide After Vaccine Therapy in… | Phase 1 | withdrawn | Oct 13, 2010 | University of Washington | not stated | Not stated |
| NCT01736878 | Efficacy and Safety Study of Sorafenib to Treat Advanced Medullary Thyroid Carcinoma(SUMMIT) | Phase 2 | withdrawn | Nov 29, 2012 | Eanm Research Ltd | Study was withdrawn due to unanticipated hassle in patient recruitment. | Enrollment / accrual |
| NCT01674374 | Botanical Therapy in Treating Mucositis in Patients With Head and Neck Cancer Who Have… | Phase 2 | withdrawn | Aug 28, 2012 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT00005812 | Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or… | Phase 2 | terminated | Jan 27, 2003 | Dartmouth-Hitchcock Medical Center | No objective response documented, protocol terminated after 12 patients. | Other (stated, no rule matched) |
| NCT00916669 | A Randomized Study to Evaluate the Effect of Two Different Doses of Enoxaparin Sodium in… | Phase 2 | withdrawn | Jun 9, 2009 | Massachusetts General Hospital | sponsor withdrew funding prior to patient enrollment | Enrollment / accrual |
| NCT01781442 | A Post Marketing Surveillance As Required By Philippine Food And Drug Administration | — | withdrawn | Feb 1, 2013 | Pfizer | not stated | Not stated |
| NCT00491075 | Pemetrexed Plus Gemcitabine in Renal Cell Cancer | Phase 2 | terminated | Jun 25, 2007 | M.D. Anderson Cancer Center | Closed early for poor accrual. | Enrollment / accrual |
| NCT01466504 | Effect of Sorafenib or Regorafenib on P63 Expression and Keratinocyte Differentiation in… | — | terminated | Nov 8, 2011 | Dartmouth-Hitchcock Medical Center | Accrual did not meet expectations. Over nearly 2 years just 4 subjects were treated on study. The… | Enrollment / accrual |
| NCT00828594 | Global Study Looking at the Combination of RAD001 and Sorafenib to Treat Patients With… | Phase 1 | terminated | Jan 26, 2009 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT01616186 | Everolimus/Sorafenib or Sunitinib in Patients With Metastatic Renal Cell Carcinoma (RCC) | Phase 2 | withdrawn | Jun 11, 2012 | Andrea Harzstark | not stated | Not stated |
| NCT00405873 | Study to Evaluate Tumour Response in Cancer Patients With Advanced Hepatocellular… | Phase 2 | terminated | Nov 30, 2006 | Auron Healthcare GmbH | Lack of efficacy | Efficacy / futility |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00429026 | Conditioning Regimen in Nonmyeloablative Allogeneic Hematopoietic Stem Cell… | Phase 2 | terminated | Jan 31, 2007 | M.D. Anderson Cancer Center | Slow accrual, study terminated. | Enrollment / accrual |
| NCT00126607 | Trastuzumab in Treating Patients With Metastatic or Recurrent Salivary Gland Cancer | Phase 2 | terminated | Aug 4, 2005 | National Cancer Institute (NCI) | Poor accrual. | Enrollment / accrual |
| NCT00601120 | RF Ablation of Treatment of Metastatic Lesions in Patients Undergoing Antiangiogenic… | N/A | withdrawn | Jan 25, 2008 | Beth Israel Deaconess Medical Center | This protocol was never officially opened and no patients were recruited. | Enrollment / accrual |
| NCT00816686 | A Phase 1 Study of the Safety and Pharmacokinetics of AGS-16M18 in Subjects With Advanced… | Phase 1 | terminated | Jan 5, 2009 | Astellas Pharma Inc | Trial was terminated due to the need to re-formulate the study drug. | Other (stated, no rule matched) |
| NCT00977561 | A Study Of Cisplatin (Or Carboplatin) And Etoposide With Or Without Figitumumab… | Phase 2 | terminated | Sep 15, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01401387 | Pancreatic Enzyme Suppletion in Pancreatic Cancer(EPC) | Phase 4 | withdrawn | Jul 25, 2011 | Foundation for Liver Research | study never started | Other (stated, no rule matched) |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00039455 | Trastuzumab and Flavopiridol in Treating Patients With Metastatic Breast Cancer | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042835 | Erlotinib and Radiation Therapy Plus Combination Chemotherapy in Treating Patients With… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00033449 | Gefitinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070122 | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced,… | Phase 3 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00005039 | Vaccine Therapy in Treating Patients With Advanced Adenocarcinoma of the Prostate… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00081211 | Intratumoral PV701 in Treating Patients With Advanced or Recurrent Unresectable Squamous… | Phase 1 | terminated | Apr 8, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00096148 | Idarubicin and Cytarabine With or Without Bevacizumab in Treating Patients With Newly… | Phase 2 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00776295 | Autologous SCT Followed by Dendritic Cell p53 Vaccination in Patients With Limited Stage… | Phase 2 | terminated | Oct 21, 2008 | H. Lee Moffitt Cancer Center and Research Institute | Low accrual | Enrollment / accrual |
| NCT00009919 | SU5416 in Treating Patients With Metastatic Kidney Cancer That Has Not Responded to… | Phase 2 | terminated | Jan 1, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042796 | Decitabine in Treating Children With Relapsed or Refractory Acute Myeloid Leukemia or… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00047333 | Erlotinib in Treating Patients With Liver Cancer That Cannot be Surgically Removed | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00061958 | Arsenic Trioxide in Treating Patients With Advanced Cancer of the Esophagus or… | Phase 2 | terminated | Jun 6, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01619696 | Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During… | Phase 2 | terminated | Jun 14, 2012 | University Hospital, Toulouse | Insufficient recruitment | Enrollment / accrual |
| NCT00005067 | Photodynamic Therapy With Lutetium Texaphyrin in Treating Patients With Locally Recurrent… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00016276 | Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and… | Phase 3 | terminated | Sep 4, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00052585 | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00699374 | Study Of Sunitinib Malate Versus Sorafenib In Patients With Inoperable Liver Cancer | Phase 3 | terminated | Jun 18, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT00512668 | Hormone Therapy and Temsirolimus in Treating Patients With Relapsed Prostate Cancer | Phase 1 | terminated | Aug 8, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01015664 | Combination of Cisplatin, Cetuximab and Temsirolimus in Recurrent or Metastatic Squamous… | Phase 1 / Phase 2 | terminated | Nov 18, 2009 | University of Tennessee Cancer Institute | not stated | Not stated |
| NCT00817362 | Efficacy and Safety of IPI-504 With Trastuzumab Pretreated, Locally Advanced or… | Phase 2 | terminated | Jan 6, 2009 | Infinity Pharmaceuticals, Inc. | Limited efficacy response observed during interim analysis. | Efficacy / futility |
| NCT01071434 | Feasibility of Using Real-time Cine-MRI for Treating Moving & Deforming Tumors | — | terminated | Feb 19, 2010 | Stanford University | PI left | Investigator |
| NCT01415986 | Interstitial Photodynamic Therapy (PDT) With Temoporfin for Advanced Head and Neck Cancers | Phase 2 | terminated | Aug 12, 2011 | University of Arkansas | The patient was "lost to follow-up" and the PI left the institution. | Investigator |
| NCT00427102 | MRX, Radiation, and Chemotherapy for Patients With Resected Squamous Cell Carcinoma of… | Phase 1 | terminated | Jan 26, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | No subjects enrolled and PI went to another facility | Enrollment / accrual |
| NCT01438021 | Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease | N/A | withdrawn | Sep 21, 2011 | City of Hope Medical Center | Lack of funding | Funding |
| NCT00966251 | Safety and Tolerability Study of the Monoclonal Antibody CT-011 in Patients With… | Phase 1 / Phase 2 | terminated | Aug 26, 2009 | CureTech Ltd | The study was stopped because of slow accrual | Enrollment / accrual |
| NCT00002921 | S9427, Suramin in Treating Patients With Stage III or Stage IV Adrenocortical Cancer… | Phase 2 | terminated | Jul 30, 2004 | SWOG Cancer Research Network | Permanently Closed Due to Lack of Accrual | Enrollment / accrual |
| NCT01009593 | Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular… | Phase 3 | terminated | Nov 6, 2009 | Abbott | See termination reason in detailed description | Other (stated, no rule matched) |
| NCT00082459 | Trial to Compare the Routes of Administration of an Investigational, Personalized,… | Phase 2 | terminated | May 12, 2004 | Agenus Inc. | Lack of enrollment | Enrollment / accrual |
| NCT00126178 | Clinical Trial Studying a Personalized Cancer Vaccine in Patients With Non-metastatic… | Phase 3 | terminated | Aug 3, 2005 | Agenus Inc. | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 29, 2013source: clinicaltrials