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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
44 stopped studies mapped to Osteosarcoma and descendants · 89% state a reason
Over the 44 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT05691478 | A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With… | Phase 2 / Phase 3 | suspended | Jan 20, 2023 | National Cancer Institute (NCI) | Other - Extend the observation period for current patients | Other (stated, no rule matched) |
| NCT04539366 | Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children,… | Phase 1 | suspended | Sep 7, 2020 | National Cancer Institute (NCI) | Other - review of safety data | Safety / toxicity |
| NCT05703854 | Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction… | Phase 1 / Phase 2 | suspended | Jan 30, 2023 | M.D. Anderson Cancer Center | PI Request | Other (stated, no rule matched) |
| NCT04751383 | Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in… | Phase 1 | terminated | Feb 12, 2021 | National Cancer Institute (NCI) | Drug supply issues | Drug supply |
| NCT06341712 | Effects of Maintenance Cabozantinib+BSC Versus BSC in Children and AYA With Osteosarcoma(CabOSTar) | Phase 2 | terminated | Apr 2, 2024 | Ipsen | The sponsor has decided to terminate the CabOSTar study due to ongoing recruitment challenges | Enrollment / accrual |
| NCT06438783 | TQB2928 Injection Combined Anlotinib Hydrochloride Capsule in Recurrent/Metastatic… | Phase 1 | terminated | Jun 3, 2024 | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | This study was closed due to business reasons. Closure was not prompted by any safety or efficacy… | Safety / toxicity |
| NCT02100891 | Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid…(STIR) | Phase 2 | terminated | Apr 1, 2014 | Monica Thakar | 15 patients enrolled out of planned 20, terminated due to slow enrollment at end of study | Enrollment / accrual |
| NCT03422679 | Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and… | Phase 1 / Phase 2 | terminated | Feb 6, 2018 | Cellestia Biotech AG | business reason | Sponsor / business decision |
| NCT03458728 | Safety, Tolerability, Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients | Phase 1 / Phase 2 | terminated | Mar 8, 2018 | Bayer | no anticipated benefit over available standard therapies | Other (stated, no rule matched) |
| NCT04365660 | 18F-FTC-146 PET/CT in Newly-Diagnosed Osteosarcoma | Phase 2 | terminated | Apr 28, 2020 | Davidzon, Guido, M.D. | lack of accrual with no intent of continuing | Enrollment / accrual |
| NCT03860207 | Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3F8-BsAb) in… | Phase 1 / Phase 2 | terminated | Mar 1, 2019 | Y-mAbs Therapeutics | study terminated due to business priorities | Sponsor / business decision |
| NCT02536183 | A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric… | Phase 1 | terminated | Aug 31, 2015 | AeRang Kim | low accrual | Enrollment / accrual |
| NCT03612466 | A Dose Finding Study of CycloSam® Combined With External Beam Radiotherapy | Phase 1 | withdrawn | Aug 2, 2018 | Albert Einstein College of Medicine | Study withdrawn before any participants could be enrolled. Issues being able to effectively recruit… | Enrollment / accrual |
| NCT04861948 | IBI188 Combination Therapy in Solid Tumors | Phase 1 | terminated | Apr 27, 2021 | Innovent Biologics (Suzhou) Co. Ltd. | No signs of efficacy in solid tumors | Efficacy / futility |
| NCT03209869 | Treatment of Relapsed or Refractory Neuroblastoma and Osteosarcoma With Expanded… | Phase 1 | withdrawn | Jul 6, 2017 | University of Wisconsin, Madison | resources limited due to COVID-19 | COVID-19 / pandemic |
| NCT05116800 | Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma | Phase 2 | withdrawn | Nov 11, 2021 | Brown University | IND withdrawn | Other (stated, no rule matched) |
| NCT02581384 | Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma,… | Phase 1 / Phase 2 | terminated | Oct 21, 2015 | Dana-Farber Cancer Institute | The study closed primarily due to weak accrual, as well as study design limitations. | Enrollment / accrual |
| NCT01759303 | Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung | Phase 2 | terminated | Jan 3, 2013 | Emerald Clinical Inc. | low accrual | Enrollment / accrual |
| NCT01987596 | Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After… | Phase 3 | terminated | Nov 19, 2013 | Barbara Ann Karmanos Cancer Institute | not stated | Not stated |
| NCT03013127 | A Study of Pembrolizumab in Patients With Relapsed Or Metastatic Osteosarcoma Not…(PROMO) | Phase 2 | terminated | Jan 6, 2017 | Oslo University Hospital | Inclusion of patients was stopped because ≤2 patients had clinical benefit. | Other (stated, no rule matched) |
| NCT00752206 | A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent… | Phase 2 | terminated | Sep 15, 2008 | Sarcoma Alliance for Research through Collaboration | The Data Safety Monitoring Board (DSMB) recommended study termination for slow accrual and futility. | Safety / toxicity |
| NCT00428272 | HGS-ETR2 to Treat Children With Solid Tumors | Phase 1 | terminated | Jan 29, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01886105 | Combination of External Beam Radiotherapy With 153Sm-EDTMP to Treat High Risk Osteosarcoma | Phase 2 | terminated | Jun 25, 2013 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low accrual and loss of funding | Enrollment / accrual |
| NCT02441309 | A Eurosarc Study of Mifamurtide in Advanced Osteosarcoma (MEMOS)(MEMOS) | Phase 2 | terminated | May 12, 2015 | University of Oxford | Failed to recruit sufficient numbers of patients in the funded period | Enrollment / accrual |
| NCT02689336 | Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory… | Phase 2 | withdrawn | Feb 23, 2016 | Washington University School of Medicine | Could not recruit any participants | Enrollment / accrual |
| NCT02718482 | Phase II Trial for the Treatment of Relapsed Osteosarcoma(OsteoREC2015) | Phase 2 | terminated | Mar 24, 2016 | Italian Sarcoma Group | Not adequate enrollment (sample size not possible to reach) | Enrollment / accrual |
| NCT02557854 | HIFU Hyperthermia With Liposomal Doxorubicin (DOXIL) for Relapsed or Refractory Pediatric… | Phase 1 | withdrawn | Sep 23, 2015 | Theodore Laetsch | Lack of enrollment | Enrollment / accrual |
| NCT01986829 | Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With… | Phase 2 | terminated | Nov 19, 2013 | Washington University School of Medicine | Slow accrual | Enrollment / accrual |
| NCT00617890 | A Study to Determine the Activity of Robatumumab (SCH 717454) in Participants With… | Phase 2 | terminated | Feb 18, 2008 | Merck Sharp & Dohme LLC | The study was prematurely terminated for strategic reasons, not for a safety concern. | Safety / toxicity |
| NCT02011126 | Imetelstat Sodium in Treating Younger Patients With Relapsed or Refractory Solid Tumors | Phase 2 | withdrawn | Dec 13, 2013 | Children's Oncology Group | IND no longer available. | Other (stated, no rule matched) |
| NCT00944580 | A Vaccine Study for High Risk Cancers | Phase 1 | withdrawn | Jul 23, 2009 | Penn State University | unexpectedly low screening results leading to poor accrual | Enrollment / accrual |
| NCT01130623 | A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors | Phase 1 | withdrawn | May 26, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01236586 | RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell… | Phase 1 | withdrawn | Nov 8, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01882231 | Quantitative Imaging Biomarkers of Treatment Response in Osteosarcoma and Ewing Sarcoma | N/A | terminated | Jun 20, 2013 | Vanderbilt-Ingram Cancer Center | Slow accrual and lack of funding | Enrollment / accrual |
| NCT01194284 | Surveillance Study of Patients With Newly Diagnosed Osteosarcoma | — | terminated | Sep 2, 2010 | Millennium Pharmaceuticals, Inc. | Regulatory agency commitment fulfilled. | Other (stated, no rule matched) |
| NCT02022358 | Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side… | Phase 2 | terminated | Dec 27, 2013 | University College, London | Recruitment almost complete, has been slow and challenging | Enrollment / accrual |
| NCT00615329 | Huntsman Biopsy Study | — | terminated | Feb 14, 2008 | State University of New York - Upstate Medical University | Huntmans Cancer Institute terminated study | Other (stated, no rule matched) |
| NCT00634322 | High Dose Methotrexate With Leucovorin Rescue With or Without Glucarpidase in Osteosarcoma | Phase 2 | terminated | Mar 13, 2008 | BTG International Inc. | Lack of enrollment | Enrollment / accrual |
| NCT00673179 | Doxorubicin With Cisplatin, High-Dose Methotrexate, and Additional Risk-Adapted… | N/A | terminated | May 7, 2008 | M.D. Anderson Cancer Center | Low accrual. | Enrollment / accrual |
| NCT01491594 | Eltrombopag for the Prevention of Chemotherapy Induced Thrombocytopenia | Phase 1 | terminated | Dec 14, 2011 | Duke University | Unable to accrue subjects to the study. | Enrollment / accrual |
| NCT01258634 | A Study of Pre-Operative Treatment of Newly-Diagnosed, Surgically-Resectable Osteosarcoma… | Phase 1 | terminated | Dec 13, 2010 | University of Chicago | PI no longer affiliated with institution; only 2 subjects enrolled | Enrollment / accrual |
| NCT01112800 | Markers of Anthracycline-Related Cardiac Muscle Injury | — | withdrawn | Apr 28, 2010 | St. Jude Children's Research Hospital | not stated | Not stated |
| NCT01492569 | Acupuncture Point Stimulation for Treatment of Chemotherapy Nausea and Vomiting | N/A | withdrawn | Dec 15, 2011 | Stanford University | low accrual | Enrollment / accrual |
| NCT00615628 | Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: | — | terminated | Feb 14, 2008 | State University of New York - Upstate Medical University | low enrollment low enrollment | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 1 hour agoSource updated Sep 29, 2026source: clinicaltrials