Clinical trial · Observational
Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:
Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): low enrollment low enrollment
Summary
Brief summary (as posted)
Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Osteosarcoma | Osteosarcoma | ONTOLOGY_EXACT | 0.90 |
| Paget's Disease | Paget Disease | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- family members
- description
- family members of the proband and father identified
Primary outcomes (1)
- measure
- Loss of heterozygosity
- timeFrame
- January, 2000 through February 2009
- description
- A loss of heterozygosity of a proposed tumor suppressor gene on chromosome 18
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18. * The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son. Exclusion Criteria: * Not part of the family
References
Publications (0)
Data not yet available