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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,672 stopped studies mapped to Malignant Reproductive System Neoplasm and descendants · 89% state a reason
Over the 1,672 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03014973 | Castration-resistant Prostate Cancer and Intra-prostatic Hormonal Status(HORM) | N/A | withdrawn | Jan 9, 2017 | Hopital Foch | not stated | Not stated |
| NCT03212807 | Study Of Durvalumab and Lenalidomide In R/R EBV Associated DLBCL Subtypes, Primary CNS…(DuRIANS) | Phase 2 | withdrawn | Jul 11, 2017 | Singapore General Hospital | FDA Hold for Combination Studies using Imids and PD1/PDL1 Compounds | Other (stated, no rule matched) |
| NCT00322881 | Carboplatin and Paclitaxel in Elderly Women With Newly Diagnosed Ovarian, Peritoneal, or… | Phase 2 | terminated | May 8, 2006 | Dana-Farber Cancer Institute | Early closure based on audit by study investigators after 3 patients died on study. | Other (stated, no rule matched) |
| NCT00910000 | Vorinostat, Carboplatin and Gemcitabine in Women With Recurrent, Platinum-Sensitive… | Phase 1 / Phase 2 | terminated | May 29, 2009 | Dana-Farber Cancer Institute | Terminated due to unacceptable toxicity | Safety / toxicity |
| NCT00039091 | Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer,… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00953576 | Ketoconazole, Hydrocortisone, Dutasteride and Lapatinib (KHAD-L) in Prostate Cancer(KHLAD) | Phase 1 / Phase 2 | terminated | Aug 6, 2009 | Dana-Farber Cancer Institute | The study terminated early due to concerns about drug toxicity. | Safety / toxicity |
| NCT00562341 | Effect of Lap-Band Induced Weight Loss on Serum PSA Levels | — | withdrawn | Nov 22, 2007 | Maimonides Medical Center | enrollment challenges | Enrollment / accrual |
| NCT01618838 | Endoscopic Evaluation of Late Rectal Injury Following CyberKnife Radiosurgery for… | N/A | terminated | Jun 13, 2012 | Georgetown University | The study only accrued 4 patients in 2 years, far below target (40). It was closed with no subject… | Enrollment / accrual |
| NCT00922818 | Study of Anatomic Nerve Sparing Radical Perineal Prostatectomy(RPP) | — | withdrawn | Jun 17, 2009 | Maimonides Medical Center | recruitment issues | Enrollment / accrual |
| NCT00730886 | ExAblate Treatment of Uterine Fibroids for Fertility Enhancement | N/A | terminated | Aug 8, 2008 | InSightec | not stated | Not stated |
| NCT00084890 | Docetaxel and Carboplatin in Treating Patients With Recurrent Stage IVB Squamous Cell… | Phase 1 | terminated | Jun 11, 2004 | Wake Forest University Health Sciences | slow accrual | Enrollment / accrual |
| NCT00527124 | Docetaxel and Prednisone With or Without Cediranib in Treating Patients With Metastatic… | Phase 2 | terminated | Sep 10, 2007 | National Cancer Institute (NCI) | Closure was recommended by CTEP due to slow accrual. | Enrollment / accrual |
| NCT00856453 | Yoga in Relieving Fatigue in Patients Undergoing Chemotherapy for Ovarian Cancer | N/A | terminated | Mar 5, 2009 | Wake Forest University Health Sciences | slow accrual | Enrollment / accrual |
| NCT01439542 | FASTR: Fairly Brief Androgen Suppression and Stereotactic Radiotherapy for High Risk…(FASTR) | Phase 2 | terminated | Sep 23, 2011 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Higher then expected Gr3 GU/GI toxicity | Safety / toxicity |
| NCT02179762 | Vigorous or Moderate Exercise in Enhancing Active Surveillance in Patients With Localized…(EASE) | N/A | withdrawn | Jul 2, 2014 | Case Comprehensive Cancer Center | Insufficient staff | Other (stated, no rule matched) |
| NCT02694380 | Measuring the Effect of Radiation Therapy on Patient Activity Levels | — | terminated | Feb 29, 2016 | University of Pittsburgh | Low accrual | Enrollment / accrual |
| NCT03465345 | Study of Metformin Plus Oligomeric Procyanidin Complex for Pharmacologic Manipulation of… | Phase 1 | withdrawn | Mar 14, 2018 | Medical University of South Carolina | Study was stopped to pursue a new treatment plan with a new study. | Other (stated, no rule matched) |
| NCT02053311 | Orteronel Maintenance Therapy in Patients With mCRPC Previously Treated With Novel… | Phase 3 | withdrawn | Feb 3, 2014 | Swiss Cancer Institute | Due to former trials, drug has not demonstrated a clinical profile sufficient to move forward in… | Other (stated, no rule matched) |
| NCT02250313 | PASCUAL (Prostate Assay Specific Clinical Utility at Launch) Study(PASCUAL) | — | terminated | Sep 26, 2014 | MDx Health | Pending final analysis for termination | Other (stated, no rule matched) |
| NCT03073473 | Evaluation of the NantHealth GPS Cancer Test in Patients With Advanced Cancers | — | terminated | Mar 8, 2017 | Cota Inc. | Poor accrual | Enrollment / accrual |
| NCT01983709 | Allogeneic Human Bone Marrow Derived Mesenchymal Stem Cells in Localized Prostate Cancer(MSC) | Phase 1 | terminated | Nov 14, 2013 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Study was Terminated by PI due to low accrual | Enrollment / accrual |
| NCT00458549 | Polyunsaturated Fatty Acids in Treating Patients With Prostate Cancer Undergoing Prostate… | N/A | terminated | Apr 11, 2007 | Dana-Farber Cancer Institute | Slow Accrual | Enrollment / accrual |
| NCT01335204 | Ph Ib/IIa Study of Cabazitaxel Plus Bavituximab in Castration-resistant Prostate Cancer | Phase 1 / Phase 2 | terminated | Apr 14, 2011 | Medical University of South Carolina | lack of funding | Funding |
| NCT02491411 | Dexamethasone Prior to Re-treatment With Enzalutamide in Treating Patients With…(DEXTER) | N/A | terminated | Jul 8, 2015 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | The study is terminated due to lower enrollment | Enrollment / accrual |
| NCT00798837 | Intraprostatic MAXimal Simultaneous Boost | N/A | terminated | Nov 26, 2008 | British Columbia Cancer Agency | Excess risk in rectal bleeding of first 10 patients | Other (stated, no rule matched) |
| NCT00634582 | Paricalcitol in Treating Patients With Advanced Prostate Cancer and Bone Metastases | Phase 2 | terminated | Mar 13, 2008 | Wake Forest University Health Sciences | slow accrual | Enrollment / accrual |
| NCT02252978 | Ciprofloxacin Compared to Placebo in Diagnosing Prostate Cancer in Patients Undergoing… | Phase 2 | withdrawn | Sep 30, 2014 | Wake Forest University Health Sciences | No funding support | Funding |
| NCT00996749 | Omega-3 Fatty Acids in Treating Patients With Advanced Prostate Cancer | N/A | withdrawn | Oct 16, 2009 | Wake Forest University Health Sciences | No Participants enrolled; slow accrual | Enrollment / accrual |
| NCT01724619 | Update and Biodistribution of [F-18]FMDHT pET/CT in Normal Healthy Volunteers and… | Early Phase 1 | terminated | Nov 12, 2012 | Wake Forest University Health Sciences | Study tracer can no longer be obtained at our institution | Other (stated, no rule matched) |
| NCT01197664 | Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer… | Phase 1 | terminated | Sep 9, 2010 | Wake Forest University Health Sciences | Study terminated due to funding issues | Funding |
| NCT02168907 | CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or… | Phase 1 | terminated | Jun 20, 2014 | Wake Forest University Health Sciences | Slow Accruals | Enrollment / accrual |
| NCT00058448 | S0224, Docetaxel in Treating Patients With Locally Advanced or Metastatic Penile Cancer… | Phase 2 | terminated | Apr 9, 2003 | SWOG Cancer Research Network | Study terminated due to poor patient recruitment. | Enrollment / accrual |
| NCT01644136 | Microspheres in Preventing Lymphatic Fluid Collection After Surgery in Patients With… | N/A | terminated | Jul 18, 2012 | Ohio State University Comprehensive Cancer Center | PI left institution | Investigator |
| NCT02215161 | Selinexor in Treating Patients With Abiraterone Acetate and/or Enzalutamide Refractory… | Phase 2 | terminated | Aug 13, 2014 | University of California, San Francisco | Risk to benefit ratio is not acceptable | Other (stated, no rule matched) |
| NCT01328067 | Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the… | N/A | withdrawn | Apr 4, 2011 | InSightec | not stated | Not stated |
| NCT02878980 | An Exercise Intervention Trial to Reduce Symptoms & Improve Clinical Outcomes of… | N/A | withdrawn | Aug 25, 2016 | City of Hope Medical Center | Feasibility issues | Other (stated, no rule matched) |
| NCT02872519 | PET Imaging of Ovarian Carcinoma With 18F-FSPG | Early Phase 1 | withdrawn | Aug 19, 2016 | Vanderbilt-Ingram Cancer Center | No funding | Funding |
| NCT01845792 | Study of Abiraterone Acetate and Prednisone in Combination With Cabazitaxel in Patients… | Phase 2 | terminated | May 3, 2013 | University of Colorado, Denver | Low accrual | Enrollment / accrual |
| NCT01987193 | Feasibility Study of Tumor Blood Flow Measurement by Detection of Positron Activation… | — | terminated | Nov 19, 2013 | University of Florida | Slow accrual; funding stopped | Enrollment / accrual |
| NCT01522443 | Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously…(COMET-2) | Phase 3 | terminated | Jan 31, 2012 | Exelixis | Stopped after the outcome of cabozantinib Phase 3 CRPC study XL184-307. | Other (stated, no rule matched) |
| NCT00866723 | Avastin in Patients With Epithelial Ovarian, Primary Peritoneal Serous or Fallopian Tube… | Phase 2 | terminated | Mar 20, 2009 | Beth Israel Deaconess Medical Center | Recruitment has been terminated prematurely because of poor enrollment. | Enrollment / accrual |
| NCT00899093 | YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian… | — | terminated | May 12, 2009 | Gynecologic Oncology Group | not stated | Not stated |
| NCT01275664 | Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients… | N/A | terminated | Jan 12, 2011 | Gynecologic Oncology Group | Study terminated due to no patient population available | Other (stated, no rule matched) |
| NCT02284971 | Pilot Study of SBRT and CDX-1127 in Prostate Cancer(Prostate-04) | Phase 1 | terminated | Nov 6, 2014 | James Larner, MD | Low accruals | Enrollment / accrual |
| NCT02818530 | Correlation Between Intraocular Pressure Measurement by Tomometer and Anterior Chamber… | N/A | terminated | Jun 29, 2016 | Tata Memorial Centre | Two patients developed corneal laceration and hence study re-reviewed by IEC and decided to… | Other (stated, no rule matched) |
| NCT02412124 | Peer-to-Peer Support Program in Improving Quality of Life Outcomes in Patients With… | N/A | terminated | Apr 8, 2015 | City of Hope Medical Center | Feasibility issues | Other (stated, no rule matched) |
| NCT02833506 | Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian… | Phase 1 | withdrawn | Jul 14, 2016 | Roswell Park Cancer Institute | production of adjuvant to be used with vaccine was discontinued by sponsor | Other (stated, no rule matched) |
| NCT02206724 | Prospective Evaluation of Stereotactic Body Radiotherapy for Metastatic Prostate Cancer | N/A | withdrawn | Aug 1, 2014 | Sharp HealthCare | Unable to enroll patients | Enrollment / accrual |
| NCT02441517 | A Study of Enzalutamide Re-treatment in Metastatic Castration-resistant Prostate Cancer… | Phase 4 | terminated | May 12, 2015 | Astellas Pharma Global Development, Inc. | The study is closed early due to lck of enrollment. | Enrollment / accrual |
| NCT00005029 | Topotecan in Treating Patients With Recurrent Ovarian Epithelial or Primary Peritoneal… | Phase 2 | terminated | Jul 19, 2004 | Gynecologic Oncology Group | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Sep 13, 2018source: clinicaltrials