Clinical trial · Interventional
Vigorous or Moderate Exercise in Enhancing Active Surveillance in Patients With Localized Prostate Cancer
Enhancing Active Surveillance With Exercise (EASE): A Pilot Randomized Trial in Localized Prostate Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Insufficient staff
Summary
Brief summary (as posted)
This randomized pilot clinical trial compares vigorous or moderate exercise in enhancing active surveillance in patients with prostate cancer that has not spread to nearby lymph nodes or to other parts of the body. Active surveillance involves watching the patient's condition but not giving any treatment unless test results show that the patient's condition is getting worse. Exercise may improve fitness, quality of life, brain health, and blood biomarkers in patients with prostate cancer on active surveillance. It is not yet known whether vigorous or moderate exercise works better in enhancing active surveillance in patients with localized prostate cancer.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Recurrent Prostate Cancer | Malignant Prostate Neoplasm | CURATED_BROADER | 0.78 |
| Stage IIA Prostate Cancer | Malignant Prostate Neoplasm | CURATED_BROADER | 0.78 |
| Stage IIB Prostate Cancer | Malignant Prostate Neoplasm | CURATED_BROADER | 0.78 |
| Stage I Prostate Cancer | Malignant Prostate Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (8)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Adherence | Behavioral | — | UNRESOLVED |
| Exercise and body composition test | Behavioral | — | UNRESOLVED |
| Exercise Logs | Behavioral | — | UNRESOLVED |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| moderate exercise intervention | Behavioral | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
| vigorous exercise intervention - cybercycling | Behavioral | — | UNRESOLVED |
| vigorous exercise intervention - standard | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Arm I (moderate intensity exercise)
- description
- Patients perform moderate intensity exercise on a stationary bike for 20-50 minutes, three days a week for 16 weeks.
- interventionNames
- Behavioral: moderate exercise intervention
- Other: questionnaire administration
- Other: laboratory biomarker analysis
- Behavioral: Exercise Logs
- Behavioral: Adherence
- Behavioral: Exercise and body composition test
- type
- EXPERIMENTAL
- label
- Arm II (HIIT exercise on a standard stationary bike)
- description
- Patients perform HIIT exercise on a standard stationary bike, three days a week for 16 weeks.
- interventionNames
- Behavioral: vigorous exercise intervention - standard
- Other: questionnaire administration
- Other: laboratory biomarker analysis
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Adult men of all races and body size with histologically confirmed localized PCa on AS * Approved to be contacted by the treating urologist * Meet screening criteria * Complete American Heart Association (AHA)/American College of Sports Medicine (ACSM) exercise questionnaire * Undergo cardiopulmonary exercise (CPX) testing utilizing a cycle ergometer. If the CPX test is terminated secondary to hemodynamic instability, arrhythmias or ischemic signs, the patient will be ineligible. Exclusion Criteria: * Patients unable to provide informed consent * Patients participating in a structured exercise program in the past 6 months * Patients not available for follow-up tests * Patients with pre-existing medical conditions that would be a barrier to exercise
References
Publications (0)
Data not yet available