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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
171 stopped studies mapped to Malignant Rectal Neoplasm and descendants · 93% state a reason
Over the 171 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03634202 | Study of Radiation Therapy in Combination With Xeloda, for Initially Metastatic, Low and…(DESIR) | N/A | terminated | Aug 16, 2018 | Institut Cancerologie de l'Ouest | the study was stopped for lack of inclusion | Other (stated, no rule matched) |
| NCT00835055 | Expression of Molecular Markers Before and After Neo-adjuvant Chemoradiotherapy in Rectal… | — | withdrawn | Feb 3, 2009 | St. Claraspital AG | never started several reasons | Other (stated, no rule matched) |
| NCT00651677 | Hand Assisted Versus "Pure" Laparoscopic Assisted Proctectomy for Rectal Cancer | N/A | withdrawn | Apr 3, 2008 | Weill Medical College of Cornell University | funding issues | Funding |
| NCT00611858 | Cetuximab, 5-FU and Radiation as Neoadjuvant Therapy for Patients With Locally Advanced… | Phase 2 | terminated | Feb 11, 2008 | Dana-Farber Cancer Institute | Slow accrual | Enrollment / accrual |
| NCT00267787 | Molecular Genetic and Pathological Studies of Anal Tumors | — | terminated | Dec 21, 2005 | Stanford University | not stated | Not stated |
| NCT01313026 | Treatment of "Low Anterior Resection Syndrome" by Percutaneous Nerve Evaluation and… | N/A | terminated | Mar 11, 2011 | University of Aarhus | Difficult to recruit participants | Enrollment / accrual |
| NCT03527784 | Prestoma-Trial for Parastomal Hernia Prevention | N/A | terminated | May 17, 2018 | University of Oulu | Parastomal Parietex withdrawn from market by the manufacturer. | Drug supply |
| NCT00254436 | A Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Weekly… | Phase 3 | terminated | Nov 16, 2005 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT02216149 | Effects of S-1 and Capecitabine on Coronary Artery Blood Flow(FluoHeart) | Phase 2 | terminated | Aug 13, 2014 | Heikki Joensuu | Slow accrual | Enrollment / accrual |
| NCT00845039 | A Study of Irinotecan and Cetuximab With or Without IMC-A12 for Treatment of Participants…(FC-4) | Phase 2 | terminated | Feb 16, 2009 | Eli Lilly and Company | Study terminated early 22Feb2010 with only 4 participants due to business reasons. | Sponsor / business decision |
| NCT01197664 | Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer… | Phase 1 | terminated | Sep 9, 2010 | Wake Forest University Health Sciences | Study terminated due to funding issues | Funding |
| NCT01887509 | Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to…(TRaMA) | N/A | terminated | Jun 27, 2013 | IHU Strasbourg | Difficulties with patients recruitment, study acceptance and protocol implementation. | Enrollment / accrual |
| NCT00663819 | Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses | N/A | terminated | Apr 22, 2008 | W.L.Gore & Associates | Per SAP | Other (stated, no rule matched) |
| NCT01919541 | Mechanistic Prehabilitation | N/A | withdrawn | Aug 9, 2013 | Franco Carli | difficulty in recruiting patients | Enrollment / accrual |
| NCT02110953 | Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal… | Phase 1 | terminated | Apr 10, 2014 | Fox Chase Cancer Center | IRB study closure by investigator due to low enrollment | Investigator |
| NCT01934179 | Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal… | — | terminated | Sep 4, 2013 | Fox Chase Cancer Center | Low Accrual Rate | Enrollment / accrual |
| NCT02163187 | Sacral Neuromodulation (SNM) With InterStimTM for Bowel Dysfunction Following Surgery for… | Phase 2 / Phase 3 | terminated | Jun 13, 2014 | Memorial Sloan Kettering Cancer Center | Study permanently closed due to low accrual | Enrollment / accrual |
| NCT02407561 | Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein… | — | terminated | Apr 3, 2015 | Castle Biosciences Incorporated | Futility - unable to secure sites and samples for participation | Efficacy / futility |
| NCT01729923 | A Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With…(ADAPT) | Phase 2 | terminated | Nov 20, 2012 | University of Washington | Funding ended | Funding |
| NCT00226941 | A Phase 1-2 Trial of Cetuximab in Combination With Oxaliplatin, Capecitabine, and… | Phase 1 / Phase 2 | terminated | Sep 27, 2005 | George Albert Fisher | The response rate observed in the phase 1 portion of the study did not merit further evaluation in… | Other (stated, no rule matched) |
| NCT02057991 | Mindfulness-Based Exercise Video in Educating Hispanic/Latino Patients With Colorectal… | N/A | terminated | Feb 7, 2014 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT03007771 | Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) Used for Mild… | Phase 1 | withdrawn | Jan 2, 2017 | Washington University School of Medicine | Decision was made to not go forward with the study | Other (stated, no rule matched) |
| NCT02609451 | Closure of Protective Ileostomy 2 vs. 12 Weeks After TME(Closure2vs12) | N/A | terminated | Nov 20, 2015 | Kantonsspital Liestal | Evidence of bad outcome after interims analysis | Other (stated, no rule matched) |
| NCT01270438 | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients… | Phase 2 | withdrawn | Jan 5, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02046538 | Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer | Phase 2 | withdrawn | Jan 27, 2014 | Weill Medical College of Cornell University | Investigator terminated due to funding issues | Investigator |
| NCT02586610 | Trial of Chemoradiation and Pembrolizumab in Patients With Rectal Cancer | Phase 2 | withdrawn | Oct 26, 2015 | Osama Rahma, MD | Dr. Rahma decided to run the study through a different group | Other (stated, no rule matched) |
| NCT02287727 | Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have… | Phase 2 | withdrawn | Nov 11, 2014 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT02266849 | Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded… | Phase 3 | terminated | Oct 17, 2014 | Odense University Hospital | Insuficcient recruiting | Enrollment / accrual |
| NCT01320683 | Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal… | Phase 2 | terminated | Mar 22, 2011 | City of Hope Medical Center | Slow accrual. | Enrollment / accrual |
| NCT02112240 | Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients | N/A | withdrawn | Apr 11, 2014 | University of Virginia | No accrual. New study opening with modified technique. | Enrollment / accrual |
| NCT01111292 | Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia | Phase 1 / Phase 2 | terminated | Apr 27, 2010 | National Cancer Institute (NCI) | The study was closed prematurely due to poor accrual. | Enrollment / accrual |
| NCT00216086 | Capecitabine + Irinotecan Followed by Combined Modality Capecitabine and Radiation in… | Phase 2 | terminated | Sep 22, 2005 | Gabi Chiorean, MD | Funding withdrawn | Funding |
| NCT02575508 | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With… | Phase 1 / Phase 2 | withdrawn | Oct 14, 2015 | Roswell Park Cancer Institute | drug supply issues | Drug supply |
| NCT00973193 | Preoperative Panitumumab and Radiotherapy in Rectal Cancer(PrePaRad) | Phase 2 | terminated | Sep 9, 2009 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | The intermediate analyses did not allowed to continue the clinical study. | Other (stated, no rule matched) |
| NCT01186705 | Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type,… | Phase 2 | terminated | Aug 23, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT00250835 | Combination of Oxaliplatin, Capecitabine, and Celecoxib With Concurrent Radiation for… | Phase 2 | terminated | Nov 8, 2005 | New Mexico Cancer Research Alliance | Low accrual | Enrollment / accrual |
| NCT01238965 | Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With… | Phase 1 | terminated | Nov 11, 2010 | University of Southern California | Adverse Events | Safety / toxicity |
| NCT01198535 | Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer | Phase 1 | terminated | Sep 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in… | Phase 2 | withdrawn | Sep 9, 2014 | University of Southern California | Lack of funding | Funding |
| NCT00575640 | Hydralazine as a Demethylating Agent in Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Dec 18, 2007 | University of Arkansas | No enrollment | Enrollment / accrual |
| NCT01717014 | Radial Reload Open LAR Case Series | N/A | terminated | Oct 30, 2012 | Medtronic - MITG | not stated | Not stated |
| NCT01659424 | Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX…(HDRBT) | Phase 2 | withdrawn | Aug 7, 2012 | Beth Israel Medical Center | No participants were enrolled | Enrollment / accrual |
| NCT01544452 | Total Preoperative MR Diagnostic Evaluation Versus Standard Diagnostic Evaluation in… | N/A | terminated | Mar 6, 2012 | Herlev Hospital | Lack of MR scanning capacity | Other (stated, no rule matched) |
| NCT01365910 | Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer | Phase 2 | terminated | Jun 3, 2011 | Vanderbilt-Ingram Cancer Center | Interim analysis determined the study did not meet criteria to proceed | Efficacy / futility |
| NCT00499369 | Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic… | Phase 3 | terminated | Jul 11, 2007 | National Cancer Institute (NCI) | Due to inadequate accrual, study was terminated and limited outcome data was reported. | Enrollment / accrual |
| NCT01198548 | High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and… | Phase 2 | terminated | Sep 10, 2010 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT01941173 | Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer… | N/A | withdrawn | Sep 13, 2013 | City of Hope Medical Center | Lack of accrual | Enrollment / accrual |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01233505 | Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Nov 3, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00088933 | Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With… | Phase 1 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated May 15, 2019source: clinicaltrials