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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
840 stopped studies mapped to Malignant Prostate Neoplasm and descendants · 92% state a reason
Over the 840 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02805894 | NBTXR3 Nanoparticles and EBRT or EBRT With Brachytherapy in the Treatment of Prostate… | Phase 1 / Phase 2 | terminated | Jun 20, 2016 | Nanobiotix | Prostate cancer treatment has greatly changed since the initiation of this trial and therefore we… | Other (stated, no rule matched) |
| NCT03478904 | Study to Compare Capsule and Liquid Formulations of Enzalutamide After Single Dose… | Phase 1 | terminated | Mar 27, 2018 | National Cancer Institute (NCI) | Study drug is now commercially available in tablet format | Other (stated, no rule matched) |
| NCT01566045 | MRI/TRUS Fusion Guided Prostate Biopsy- An Improved Way to Detect and Quantify Prostate… | N/A | withdrawn | Mar 29, 2012 | Philips Healthcare | not stated | Not stated |
| NCT00621413 | Observation of Outcomes and Side Effects of Cesium-131 in Combination With External Beam… | — | withdrawn | Feb 22, 2008 | IsoRay Medical, Inc. | Study never moved forward due to no accrual | Enrollment / accrual |
| NCT02497638 | LIpitor and biGuanide to Androgen Delay Trial(LIGAND) | Phase 2 | withdrawn | Jul 14, 2015 | University Health Network, Toronto | Drug intervention no longer relevant for the proposed population | Other (stated, no rule matched) |
| NCT02685267 | Docetaxel/Prednisone Versus Docetaxel/Prednisone and Enzalutamide in Castration-Resistant…(Doce/Enza) | Phase 2 | terminated | Feb 18, 2016 | Prostate Cancer Clinical Trials Consortium | not stated | Not stated |
| NCT00991315 | Collecting and Storing Blood and Tumor Tissue Samples From Patients Undergoing… | — | terminated | Oct 8, 2009 | Rutgers, The State University of New Jersey | Specimens are now collected through the BRS protocol. | Other (stated, no rule matched) |
| NCT02853097 | Cell-Free DNA and RNA in Blood fromMetastatic Prostate Cancer Patients | — | terminated | Aug 2, 2016 | University of Southern California | Slow accrual | Enrollment / accrual |
| NCT01376661 | Outcome Assessment of an Active Surveillance Program for Low Risk Prostate Cancer: An… | — | terminated | Jun 20, 2011 | St. Joseph Hospital of Orange | Early termination due to PI's decision to discontinue research activities. | Other (stated, no rule matched) |
| NCT03589781 | Investigating the Effects of Mikei® Red Reishi Essence EX on the Immune System of… | N/A | withdrawn | Jul 18, 2018 | Nikkei (Canada) Marketing Limited | Covid 19 Pandemic - Unable to enroll patients | COVID-19 / pandemic |
| NCT03042312 | Lutetium-177 (Lu177) Prostate-Specific Antigen (PSMA)-Directed EndoRadiotherapy(RESIST-PC) | Phase 2 | terminated | Feb 3, 2017 | Endocyte | Recruitment was stopped before the target sample size was achieved. | Enrollment / accrual |
| NCT04305379 | Augmented BLAdder NecK rEconstruction Trial for Improved Urinary Function After Radical…(BLANKET) | N/A | terminated | Mar 12, 2020 | Johns Hopkins University | Stopped due to COVID-19 pandemic, low priority among initiatives and officially terminated. | COVID-19 / pandemic |
| NCT02295163 | Stellate Ganglion Block for Hot Flushes in Men Treated With ADT | N/A | withdrawn | Nov 20, 2014 | Rijnstate Hospital | no participants | Other (stated, no rule matched) |
| NCT03572478 | Rucaparib and Nivolumab in Patients With Prostate or Endometrial Cancer | Phase 1 / Phase 2 | terminated | Jun 28, 2018 | University of Chicago | The study was terminated due to lack of efficacy. | Efficacy / futility |
| NCT01717677 | Evaluation of Four Treatment Modalities in Prostate Cancer With Low or "Early…(PREFERE) | N/A | terminated | Oct 30, 2012 | Association of Urologic Oncology (AUO) | Insufficient Recruitment | Enrollment / accrual |
| NCT03261336 | Oral Calcitriol With Ketoconazole in CRPC | Phase 2 | terminated | Aug 25, 2017 | Donald Trump, MD | can not meet enrollment | Enrollment / accrual |
| NCT03741712 | A Study of SHR2554 Alone or in Combination With SHR3680 in the Treatment of mCRPC | Phase 1 / Phase 2 | terminated | Nov 15, 2018 | Jiangsu HengRui Medicine Co., Ltd. | According to the available data from the trial，the sponsor determined to terminate this study. | Other (stated, no rule matched) |
| NCT03514836 | A Phase I/II, Safety Clinical Trial of DCVAC/PCa and ONCOS-102 in Men With Metastatic… | Phase 1 / Phase 2 | terminated | May 2, 2018 | SOTIO a.s. | insufficient accrual | Enrollment / accrual |
| NCT02698176 | A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Advanced… | Phase 1 | terminated | Mar 3, 2016 | Merck Sharp & Dohme LLC | This study was terminated due to limited efficacy and not due to safety reasons. | Safety / toxicity |
| NCT02844582 | Cabazitaxel and Prednisone in Treating Patients With Metastatic Hormone-Resistant… | Phase 2 | terminated | Jul 26, 2016 | University of California, Davis | Poor accrual of subjects onto study | Enrollment / accrual |
| NCT04585932 | Androgen Deprivation Therapy and Apalutamide With or Without Radiation Therapy for the… | Phase 2 | withdrawn | Oct 14, 2020 | M.D. Anderson Cancer Center | At the request of the ad interim Department Chairman due to PI is no longer at institution. | Other (stated, no rule matched) |
| NCT03327662 | Utilising CTC Counts to Optimize Systemic Therapy of Metastatic Prostate Cancer(CTC-STOP) | Phase 3 | terminated | Oct 31, 2017 | Institute of Cancer Research, United Kingdom | Underrecruitment | Other (stated, no rule matched) |
| NCT00757757 | A Phase I/II Open-label Study of MCS110 in Patients With Prostate Cancer and Bone… | Phase 1 / Phase 2 | terminated | Sep 23, 2008 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT04027270 | Pelvic Health and Physical Therapy to Improve Lives of Prostate Cancer Patients… | N/A | withdrawn | Jul 19, 2019 | University of Missouri-Columbia | Covid | COVID-19 / pandemic |
| NCT03563352 | Nutritional Preferences and Product Accessibility in Oral Nutritional Supplements in… | — | withdrawn | Jun 20, 2018 | University of Southern California | Zero accrual | Enrollment / accrual |
| NCT00058188 | Zolendronate for the Prevention of Bone Loss in Men w/ Prostate CA on Long-Term Androgen… | Phase 3 | terminated | Apr 9, 2003 | Northwestern University | Closed by the research committee | Other (stated, no rule matched) |
| NCT00780975 | A Study of Aplidin ( Plitidepsin) in Subjects With Advanced Prostate Cancer | Phase 2 | terminated | Oct 28, 2008 | PharmaMar | Poor recruitment | Enrollment / accrual |
| NCT03308734 | Effects of 6 Week Reduced Exertion High Intensity Interval Training Protocol in Patients… | N/A | withdrawn | Oct 13, 2017 | University of Bath | Lack of resource from collaborating organisation | Other (stated, no rule matched) |
| NCT01691976 | Mild Cognitive Impairment in Men Following Androgen Deprivation | N/A | withdrawn | Sep 25, 2012 | Imperial College London | No one recruited due to resource limitations. Issues with how complicated the study could be for… | Enrollment / accrual |
| NCT04225299 | Evaluation of Efficacy of TOOKAD® (VTP) Versus Active Surveillance for Intermediate Risk… | Phase 3 | withdrawn | Jan 13, 2020 | Steba Biotech S.A. | FDA didn't approve the design of the protocol so we didn't start the study | Other (stated, no rule matched) |
| NCT04399824 | Focal Radiation Therapy for the Treatment of Low or Intermediate-Risk Prostate Cancer | N/A | withdrawn | May 22, 2020 | Jonsson Comprehensive Cancer Center | Study did not open | Other (stated, no rule matched) |
| NCT04266262 | High-Intensity Training for Men With Prostate Cancer on Active Surveillance: A… | N/A | terminated | Feb 12, 2020 | University of Toronto | All research activities were suspended as a result of COVID-19. | COVID-19 / pandemic |
| NCT03724253 | [68Ga]-NeoBOMB1 Imaging in Patients With Malignancies Known to Overexpress Gastrin…(NeoFIND) | Phase 2 | terminated | Oct 30, 2018 | Advanced Accelerator Applications | Recruitment was stopped before the target sample size was achieved. | Enrollment / accrual |
| NCT01928485 | Green Tea Extract in Treating Patients With Low-Risk Prostate Cancer | Phase 2 | terminated | Aug 26, 2013 | Sanjay Gupta PhD | Slow Accrual | Enrollment / accrual |
| NCT02006927 | A Pilot Study of the Feasibility of Chronic Cavernous Nerve Stimulation to Promote… | N/A | terminated | Dec 10, 2013 | Kenneth M Peters, MD | Lack of Enrollment | Enrollment / accrual |
| NCT00004026 | CT-2584 in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to… | Phase 2 | terminated | Aug 27, 2004 | CTI BioPharma | not stated | Not stated |
| NCT03110588 | Phase I Trial of PACE for Metastatic Prostate Cancer | Phase 1 | withdrawn | Apr 12, 2017 | University of Alabama at Birmingham | PI left the institution | Investigator |
| NCT02822963 | Impact of Anticoagulants and Antiplatelets in Patients on Transurethral Resection of the… | — | withdrawn | Jul 6, 2016 | National Cheng-Kung University Hospital | No funding | Funding |
| NCT03570476 | Olaparib Before Surgery in Treating Participants With Localized Prostate Cancer | Phase 2 | terminated | Jun 27, 2018 | University of Washington | Terminated due to slow accrual | Enrollment / accrual |
| NCT01079793 | Radiation Therapy and Ixabepilone in Treating Patients With High-Risk Stage III Prostate… | Phase 1 / Phase 2 | withdrawn | Mar 3, 2010 | University of Texas Southwestern Medical Center | Overlapping study, PI preferred to enroll in alternate trial. | Enrollment / accrual |
| NCT01414712 | Circulating Tumor Cells in Prostate Cancer Patients | — | terminated | Aug 11, 2011 | University of Texas Southwestern Medical Center | not stated | Not stated |
| NCT03488810 | Apalutamide With Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer(ARN-509) | Phase 3 | withdrawn | Apr 5, 2018 | European Organisation for Research and Treatment of Cancer - EORTC | Extended study timelines and additional budget could no longer be supported. | Funding |
| NCT03006562 | PREvention of VENous ThromboEmbolism Following Radical Prostatectomy(PREVENTER) | Phase 4 | terminated | Dec 30, 2016 | Johns Hopkins University | Early stopping point based on 2nd interim analysis (planned per protocol) | Efficacy / futility |
| NCT01859689 | Internal Radiation Therapy in Treating Patients With Low-Risk Prostate Cancer | Phase 2 | withdrawn | May 22, 2013 | Jonsson Comprehensive Cancer Center | no participants enrolled | Enrollment / accrual |
| NCT02597894 | Targeted Biopsies in Determining Response in Patients With Prostate Cancer Undergoing… | N/A | withdrawn | Nov 5, 2015 | Jonsson Comprehensive Cancer Center | P. I. left the Institution. Study never opened | Other (stated, no rule matched) |
| NCT02911467 | Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (HP) (13C) in…(MR) | Phase 1 | terminated | Sep 22, 2016 | Rahul Aggarwal | Low Accrual | Enrollment / accrual |
| NCT02168062 | Supportive Therapy in Androgen Deprivation Clinic in Improving Health Outcomes and… | Phase 2 | terminated | Jun 20, 2014 | University of California, San Francisco | Funding | Funding |
| NCT03596710 | Image-Guided Biopsies in Identifying Mechanisms of Resistance in Participants With… | N/A | withdrawn | Jul 24, 2018 | Jonsson Comprehensive Cancer Center | sponsor withdrew study | Other (stated, no rule matched) |
| NCT04272645 | Abemaciclib With or Without Atezolizumab in Metastatic Castration Resistant Prostate… | Phase 2 | withdrawn | Feb 17, 2020 | University of Michigan Rogel Cancer Center | Coordinating site change | Other (stated, no rule matched) |
| NCT03321864 | Capture of Prostatic Trans-rectal Ultrasound Scans for Research(CAPTURE) | N/A | suspended | Oct 26, 2017 | Cambridge University Hospitals NHS Foundation Trust | PI has left Trust currently. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 10, 2021source: clinicaltrials