Circulating Tumor Cells in Prostate Cancer Patients

Inclusion Criteria:

Men who satisfy all of the following conditions will be eligible for this study:

* Willing and capable to provide informed consent
* Signed study specific informed consent form.
* PSA ≤ 20 prior to hormone therapy (if given) for patients with Gleason 2-6. For those with Gleason score of 7. PSA should be less than or equal to 15 ng/ml prior to hormonal therapy (if given). Thus, risk of pelvic lymph node involvement according to Roach formula would be under 20%.
* Gleason score ≤ 7
* Appropriate staging studies identifying as AJCC stage T1a, T1b, T1c, T2a, or T2b
* No direct evidence of regional or distant metastases after appropriate staging studies
* Histologic confirmation of cancer by biopsy
* Adenocarcinoma of the prostate
* Age ≥ 18
* Zubrod Performance Status 0-2
* Up to 9 months of previous hormonal therapy is allowed (but not required)
* AUA score must be ≤ 15 (alpha blockers allowed)
* CT or Ultrasound-based volume estimation of prostate gland ≤ 60 grams
* Agreement to use effective contraceptive methods such as condom/diaphragm and spermicidal foam, intrauterine device, or prescription birth control pills.

Exclusion Criteria:

Women are not eligible for this study. Men with one or more of the following conditions also are ineligible for this study:

* Positive lymph nodes or metastatic disease from prostate cancer
* Prior invasive malignancy unless disease free for a minimum of 3 years (carcinoma in situ of the breast, oral cavity, or cervix, or non-melanomatous skin cancer are all permissible)
* T2c, T3, or T4 tumors
* Previous pelvic radiotherapy
* Previous surgery or chemotherapy for prostate cancer
* Previous transuretheral resection of the prostate (TURP) or cryotherapy to the prostate
* Previous hormonal therapy given for more than 9 months prior to therapy
* Concomitant antineoplastic therapy (including surgery, cryotherapy, conventionally fractionated radiotherapy, and chemotherapy) while on this protocol.
* History of Crohn's Disease or Ulcerative Colitis.
* Previous significant obstructive symptoms; AUA score must be ≤ 15 (alpha blockers allowed)
* Significant psychiatric illness
* Men of reproductive potential may not participate unless they agree to use an effective contraceptive method.
* Ultrasound or CT estimate of prostate volume \> 60 grams