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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12,388 stopped studies mapped to Malignant Neoplasm and descendants · 89% state a reason
Over the 12,388 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00437749 | A Study of CBT-1 and Paclitaxel With Carboplatin in Patients With Advanced Inoperable… | Phase 3 | terminated | Feb 21, 2007 | CBA Research | slow accrual rate; interim accrual objective met | Enrollment / accrual |
| NCT01215266 | Sorafenib in Urothelium Cancer of Bladder | Phase 2 | terminated | Oct 6, 2010 | Association of Urologic Oncology (AUO) | Slow recruitment | Enrollment / accrual |
| NCT00428077 | Vaccine Therapy in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia | Phase 2 | terminated | Jan 29, 2007 | OHSU Knight Cancer Institute | Withdrawn because there were no dramatic changes in the main endpoint, as well as low enrollment… | Efficacy / futility |
| NCT00430443 | Liposomal Annamycin in Children and Young Adults With Refractory or Relapsed ALL or AML | Phase 1 | terminated | Feb 1, 2007 | Callisto Pharmaceuticals | Participants are no longer being examined or treated. | Other (stated, no rule matched) |
| NCT00107614 | DT PACE, Tandem Autologous Transplant, Maintenance Therapy for Waldenstrom's… | Phase 2 | terminated | Apr 6, 2005 | University of Arkansas | Terminated due to poor accrual. | Enrollment / accrual |
| NCT00281996 | Imatinib Mesylate and Gemcitabine in Treating Patients With Locally Advanced, Metastatic,… | Phase 1 | terminated | Jan 25, 2006 | Northwestern University | Closed to accrual to allow enrollment on another more promising trial. | Enrollment / accrual |
| NCT00023790 | Photodynamic Therapy in Treating Patients With Skin Cancer or Solid Tumors Metastatic to… | Phase 1 | terminated | Jan 27, 2003 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00732745 | Vandetanib, Oxaliplatin, and Docetaxel in Advanced Cancer of the Esophagus or… | Phase 1 | terminated | Aug 12, 2008 | Case Comprehensive Cancer Center | Lost funding for Phase II portion of study | Funding |
| NCT00915811 | Pilot Study of Reduced Intensity Haematopoietic Stem Cell Transplantation in Patients…(FB-ATG) | Phase 2 | terminated | Jun 8, 2009 | King's College Hospital NHS Trust | FB ATG is now a standard for sib allo MDS patients | Other (stated, no rule matched) |
| NCT00573391 | Study of Multiple Myeloma Patients Relapsing or Progressing After Autologous… | Phase 3 | terminated | Dec 14, 2007 | University of Arkansas | low accrual | Enrollment / accrual |
| NCT00839059 | Lenalidomide In Patients With Acute Myeloid Leukemia | Phase 1 | terminated | Feb 9, 2009 | University of Ulm | Results of an interim analysis and a hardly ongoing enrolment in the last 10 months in all six… | Efficacy / futility |
| NCT00805012 | Docetaxel and S-1 in Head and Neck Squamous Cell Carcinoma (HNSCC) | Phase 2 | terminated | Dec 9, 2008 | Seoul National University Hospital | slow accrual rate | Enrollment / accrual |
| NCT00830245 | A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR… | Phase 2 | terminated | Jan 27, 2009 | Clinical Research Center for Solid Tumor, Korea | low accrual rate | Enrollment / accrual |
| NCT00683085 | Human Leukocyte Antigen-A*02:01-restricted Tumor Vessel Specific Peptide Vaccination for… | Phase 1 / Phase 2 | terminated | May 23, 2008 | Tokyo University | Lack of eligible patient | Other (stated, no rule matched) |
| NCT00002778 | Sargramostim Following Allogeneic Bone Marrow Transplantation in Treating Patients With… | Phase 2 | terminated | Jan 27, 2003 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | subject accrual and data analysis is completed. | Enrollment / accrual |
| NCT00003561 | Interferon Alfa Plus Sargramostim in Treating Patients With Newly Diagnosed Chronic Phase… | Phase 2 | terminated | Mar 22, 2004 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | not stated | Not stated |
| NCT00524667 | HDAC Inhibitor Valproic Acid as an Effective Therapy for Chronic Lymphocytic Leukemia | Phase 2 | terminated | Sep 3, 2007 | CancerCare Manitoba | Terminated due to poor accrual. | Enrollment / accrual |
| NCT00725400 | Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in… | Phase 2 | withdrawn | Jul 30, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT00880867 | Intratumoral Poly-ICLC Plus Low Dose Local Radiation in Low Grade Recurrent B and T Cell… | Phase 1 | terminated | Apr 14, 2009 | Nevada Cancer Institute | Low enrollment | Enrollment / accrual |
| NCT00886457 | 5-aza-2-deoxycytidine With Pegylated Interferon-alfa 2B: A Phase I Study With Molecular… | Phase 1 | terminated | Apr 23, 2009 | Nevada Cancer Institute | low accrual | Enrollment / accrual |
| NCT01125787 | Clinical Protocol for the Treatment of Patients With Previously Untreated Chronic… | Phase 2 | terminated | May 18, 2010 | Nevada Cancer Institute | Low enrollment | Enrollment / accrual |
| NCT01131247 | PH2 Trial in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) With a… | Phase 2 | withdrawn | May 26, 2010 | Nevada Cancer Institute | PI left institution | Investigator |
| NCT00898781 | Study of Circulating Cancer Cells in Patients With Metastatic Breast, Ovarian, Colon, or… | — | terminated | May 12, 2009 | Mayo Clinic | Due to poor accrual | Enrollment / accrual |
| NCT00970645 | Study Comparing EBUS & EUS to Mediastinoscopy in Staging and Detection of Lung Cancer | N/A | terminated | Sep 2, 2009 | Mayo Clinic | Similar study published results | Other (stated, no rule matched) |
| NCT01126866 | Curative Resectability of Not Optimally Resectable Liver and/or Lung Metastases From…(APRIORI) | Phase 2 | terminated | May 20, 2010 | National Center for Tumor Diseases, Heidelberg | recruiting inadequate | Enrollment / accrual |
| NCT00530205 | Effects of Radiation Therapy on the Body in Patients With Stage III Non-Small Cell Lung… | — | withdrawn | Sep 17, 2007 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00768339 | A Phase 1-2, Multicenter, Open-Label Study of AEG35156 in Patients With Relapsed or… | Phase 1 / Phase 2 | terminated | Oct 8, 2008 | Aegera Therapeutics | Slow recruitment | Enrollment / accrual |
| NCT01018069 | AEG35156 in Combination With High-dose Cytarabine and Idarubicin in AML Following Failure… | Phase 2 | terminated | Nov 23, 2009 | Aegera Therapeutics | Failed to reach endpoints | Other (stated, no rule matched) |
| NCT00118300 | Capecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical… | Phase 1 | withdrawn | Jul 11, 2005 | Case Comprehensive Cancer Center | Competing studies | Other (stated, no rule matched) |
| NCT00658801 | Study of Respiratory Gated Proton Beam Radiotherapy for Inoperable Pancreas Carcinoma | Phase 1 | terminated | Apr 15, 2008 | National Cancer Center, Korea | difficult to register | Other (stated, no rule matched) |
| NCT00369447 | A Study of Nimotuzumab in Combination With External Radiotherapy in Non-Small Cell Lung… | Phase 1 / Phase 2 | terminated | Aug 29, 2006 | YM BioSciences | The study was closed due to slow accrual. | Enrollment / accrual |
| NCT00872482 | A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain… | Phase 2 | terminated | Mar 31, 2009 | YM BioSciences | Study closed due to low enrollment | Enrollment / accrual |
| NCT00112619 | Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia,… | Phase 1 | terminated | Jun 3, 2005 | Pediatric Brain Tumor Consortium | Slow accrual and company withdrawing support to supply the drug | Drug supply |
| NCT01050725 | Pilot Study of Biomarkers for Radiation Therapy | — | suspended | Jan 15, 2010 | Benaroya Research Institute | On hold: pending grant funding for further enrollment | Enrollment / accrual |
| NCT00415454 | Study Combining Suicide Gene Therapy With Chemoradiotherapy in the Treatment of… | Phase 1 | terminated | Dec 25, 2006 | Henry Ford Health System | Poor enrollment | Enrollment / accrual |
| NCT00532285 | Primary Paclitaxel Plus Gemcitabine in Patients With Stage II and III Breast Cancer | Phase 2 | terminated | Sep 20, 2007 | National Cancer Center, Korea | terminated | Other (stated, no rule matched) |
| NCT01096745 | Randomized Trial of Gemcitabine/Cisplatin Versus S-1/Cisplatin in Advanced Biliary Cancer | Phase 2 | terminated | Mar 31, 2010 | Gyeongsang National University Hospital | Planning for randomized phase III trial for this issue. | Other (stated, no rule matched) |
| NCT00563862 | Benefit of Adding Chemotherapy And/Or Modification of Radiotherapy Schedule for Advance… | N/A | terminated | Nov 26, 2007 | Hospital Authority, Hong Kong | not stated | Not stated |
| NCT00568308 | Phase III Study of PI-88 in Post-resection Hepatocellular Carcinoma(PATHWAY) | Phase 3 | terminated | Dec 6, 2007 | Progen Pharmaceuticals | Commercial decision to discontinue the study | Other (stated, no rule matched) |
| NCT01116128 | Dasatinib in Combination With Melphalan and Prednisone to Treat Relapsed and Refractory…(D-MP) | Phase 2 | terminated | May 4, 2010 | Fondazione EMN Italy Onlus | difficulty in enrolling patients | Enrollment / accrual |
| NCT00355745 | Safety and Efficacy of Using CBUS™ System for Ultrasound Breast Imaging Designed for… | N/A | terminated | Jul 25, 2006 | Helix Medical Systems | not stated | Not stated |
| NCT00942396 | Study to Compare the Diagnostic Accuracy of Nuance Full-Field Digital Mammography to… | Phase 3 | withdrawn | Jul 20, 2009 | Planmed Oy | FDA changed classification of device and no longer requires this type of clinical data | Other (stated, no rule matched) |
| NCT00101062 | Letrozole and Celecoxib in Treating Postmenopausal Women With Locally Advanced or… | Phase 2 | terminated | Jan 10, 2005 | University of Medicine and Dentistry of New Jersey | study drug unavailable | Other (stated, no rule matched) |
| NCT00127517 | Palliative Care Study in Patients With Advanced Cancer | Phase 2 | terminated | Aug 8, 2005 | Advanced Viral Research Corp | Company shifted focus | Sponsor / business decision |
| NCT00550004 | Phase II Study to Evaluate Efficacy and Safety of RP101 in Combination With Gemcitabine(RP101) | Phase 2 | terminated | Oct 26, 2007 | SciClone Pharmaceuticals | not stated | Not stated |
| NCT00851448 | Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Lung Cancer Patients | N/A | terminated | Feb 26, 2009 | Fresenius Kabi | not stated | Not stated |
| NCT00539331 | Phase I/II Study of AZD2171 in Combination With Paclitaxel/Carboplatin in Japanese… | Phase 1 | terminated | Oct 4, 2007 | AstraZeneca | not stated | Not stated |
| NCT01143311 | Role of microRNA in the Development of Cutaneous Squamous Cell Carcinoma | N/A | terminated | Jun 14, 2010 | Centre Hospitalier Universitaire de Nice | not stated | Not stated |
| NCT01363466 | Evaluation of Hysterectomy After Chemoradiation Therapy for Stage IB2/II Cervical Cancer | Phase 3 | terminated | Jun 1, 2011 | UNICANCER | low recruitment | Enrollment / accrual |
| NCT00343187 | A Phase II Study of ACZONE™ (Dapsone) Gel, 5% As a Treatment For Tarceva®… | Phase 2 | terminated | Jun 22, 2006 | Allergan | Lack of enrollment | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Sep 9, 2011source: clinicaltrials