Clinical trial · Observational
Pilot Study of Biomarkers for Radiation Therapy
Investigating Proteomic Biomarkers of Radiation Therapy Outcome: A Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): On hold: pending grant funding for further enrollment
Summary
Brief summary (as posted)
The purpose of this study is to determine whether specific assays of DNA damage repair proteins can be used in patients undergoing radiation therapy. The ultimate goal of this research is to develop clinically useful biomarkers from blood samples that could be used to customize radiation treatment for individuals, leading to reduced side effects and improved outcomes.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Radiation therapy patients
- description
- Individuals receiving radiation therapy as definitive or neo-adjuvant therapy for selected malignancies, including head and neck, lung, esophageal, rectal cervical and prostate cancers.
Primary outcomes (0)
[]Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients \> 18 years of age with primary lung, esophageal or rectal cancer receiving neo-adjuvant chemoradiotherapy before planned resection * patients with clinically localized prostate cancer receiving definitive radiation therapy with external beam treatment. brachytherapy as a boost and/or hormonal therapy are allowed. * patients with head and neck, lung, esophageal or cervical cancer who will receive definitive radiotherapy Exclusion Criteria: * prior history of chemotherapy given within 6 months before enrollment. * prior radiotherapy or radionuclide treatment and/or brachytherapy within 6 months prior to enrollment. * unwillingness to comply with tests, protocol, or informed consent. * concurrent enrollment on any protocol that would require non-compliance with treatment procedures. * chemotherapy required within 2 hours following first dose of XRT. * PET scan done within 48 hours of first blood draw. * nuclear medicine exposure within 4 days prior to first draw.
References
Publications (0)
Data not yet available