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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
876 stopped studies mapped to Malignant Male Reproductive System Neoplasm and descendants · 91% state a reason
Over the 876 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03110588 | Phase I Trial of PACE for Metastatic Prostate Cancer | Phase 1 | withdrawn | Apr 12, 2017 | University of Alabama at Birmingham | PI left the institution | Investigator |
| NCT02822963 | Impact of Anticoagulants and Antiplatelets in Patients on Transurethral Resection of the… | — | withdrawn | Jul 6, 2016 | National Cheng-Kung University Hospital | No funding | Funding |
| NCT03570476 | Olaparib Before Surgery in Treating Participants With Localized Prostate Cancer | Phase 2 | terminated | Jun 27, 2018 | University of Washington | Terminated due to slow accrual | Enrollment / accrual |
| NCT01079793 | Radiation Therapy and Ixabepilone in Treating Patients With High-Risk Stage III Prostate… | Phase 1 / Phase 2 | withdrawn | Mar 3, 2010 | University of Texas Southwestern Medical Center | Overlapping study, PI preferred to enroll in alternate trial. | Enrollment / accrual |
| NCT01414712 | Circulating Tumor Cells in Prostate Cancer Patients | — | terminated | Aug 11, 2011 | University of Texas Southwestern Medical Center | not stated | Not stated |
| NCT03488810 | Apalutamide With Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer(ARN-509) | Phase 3 | withdrawn | Apr 5, 2018 | European Organisation for Research and Treatment of Cancer - EORTC | Extended study timelines and additional budget could no longer be supported. | Funding |
| NCT03006562 | PREvention of VENous ThromboEmbolism Following Radical Prostatectomy(PREVENTER) | Phase 4 | terminated | Dec 30, 2016 | Johns Hopkins University | Early stopping point based on 2nd interim analysis (planned per protocol) | Efficacy / futility |
| NCT01859689 | Internal Radiation Therapy in Treating Patients With Low-Risk Prostate Cancer | Phase 2 | withdrawn | May 22, 2013 | Jonsson Comprehensive Cancer Center | no participants enrolled | Enrollment / accrual |
| NCT02597894 | Targeted Biopsies in Determining Response in Patients With Prostate Cancer Undergoing… | N/A | withdrawn | Nov 5, 2015 | Jonsson Comprehensive Cancer Center | P. I. left the Institution. Study never opened | Other (stated, no rule matched) |
| NCT02911467 | Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (HP) (13C) in…(MR) | Phase 1 | terminated | Sep 22, 2016 | Rahul Aggarwal | Low Accrual | Enrollment / accrual |
| NCT02168062 | Supportive Therapy in Androgen Deprivation Clinic in Improving Health Outcomes and… | Phase 2 | terminated | Jun 20, 2014 | University of California, San Francisco | Funding | Funding |
| NCT03596710 | Image-Guided Biopsies in Identifying Mechanisms of Resistance in Participants With… | N/A | withdrawn | Jul 24, 2018 | Jonsson Comprehensive Cancer Center | sponsor withdrew study | Other (stated, no rule matched) |
| NCT04272645 | Abemaciclib With or Without Atezolizumab in Metastatic Castration Resistant Prostate… | Phase 2 | withdrawn | Feb 17, 2020 | University of Michigan Rogel Cancer Center | Coordinating site change | Other (stated, no rule matched) |
| NCT03321864 | Capture of Prostatic Trans-rectal Ultrasound Scans for Research(CAPTURE) | N/A | suspended | Oct 26, 2017 | Cambridge University Hospitals NHS Foundation Trust | PI has left Trust currently. | Other (stated, no rule matched) |
| NCT03827473 | Docetaxel or Abiraterone Acetate With ADT in Treating Patients With Metastatic Hormone…(ACADEMIC) | Phase 2 | terminated | Feb 1, 2019 | University of Utah | The trial was closed because the changing standard of care landscape, making this trial not… | Other (stated, no rule matched) |
| NCT03748719 | Single Arm Trial of Preoperative Stereotactic Body Radiation Therapy (SBRT) for T3a or… | N/A | withdrawn | Nov 21, 2018 | H. Lee Moffitt Cancer Center and Research Institute | No accrual interest | Enrollment / accrual |
| NCT00003645 | Randomized Trial of Adjuvant Hormonal Therapy in Surgically Treated Prostate Cancer… | Phase 3 | terminated | Jul 15, 2003 | M.D. Anderson Cancer Center | Per PI request | Other (stated, no rule matched) |
| NCT02541903 | Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma | Phase 2 | terminated | Sep 4, 2015 | University of Alabama at Birmingham | poor overall accrual | Enrollment / accrual |
| NCT03093272 | A Study of Docetaxel + ARN-509 in Castration-Resistant Prostate Cancer | Phase 2 | terminated | Mar 28, 2017 | Dana-Farber Cancer Institute | Safety concerns | Safety / toxicity |
| NCT02091661 | Radical Retropubic Prostatectomy Versus Conventional External Beam Radiotherapy for… | Phase 3 | suspended | Mar 19, 2014 | University of Rome Tor Vergata | accrual too slow | Enrollment / accrual |
| NCT03634579 | MRI Guided Prostate Cancer Focal Laser Ablation | N/A | terminated | Aug 16, 2018 | Emory University | Lack of funding for continuation. | Funding |
| NCT01766869 | Improving Cancer Foci Detection in Prostate Cancer Using Multiparametric MRI/MRS(GCC 1261) | — | withdrawn | Jan 11, 2013 | University of Maryland, Baltimore | No participants enrolled | Enrollment / accrual |
| NCT03763851 | Cannabis Oil and Radiation Therapy for the Management of Pain | Phase 2 | terminated | Dec 4, 2018 | Tetra Bio-Pharma | due to mycotoxin potential contamination of one lot of study drug | Other (stated, no rule matched) |
| NCT03817216 | Prostatic Urethral Lift (PUL) Pre-/Post-Radiation Treatment for Prostate Cancer | N/A | withdrawn | Jan 25, 2019 | Case Comprehensive Cancer Center | re-written and submitted as a new study | Other (stated, no rule matched) |
| NCT03137758 | A Phase I Study of PCUR-101 in Combination With Androgen Suppression Therapy in the… | Phase 1 | terminated | May 3, 2017 | Pellficure Pharmaceuticals, Inc | Reformulation of study drug to help reduce the pill burden as higher doses are evaluated. | Other (stated, no rule matched) |
| NCT01499043 | Pilot Study of PLX3397 in Patients With Advanced Castration-Resistant Prostate Cancer… | Phase 2 | terminated | Dec 26, 2011 | Daiichi Sankyo | Business decision. | Sponsor / business decision |
| NCT02811809 | Apalutamide Plus Intermittent Hormone Therapy Versus Intermittent Hormone Therapy Alone… | Phase 2 | withdrawn | Jun 23, 2016 | The University of Texas Health Science Center, Houston | Withdrawn due to operational issues. The study was withdrawn early, before enrolling its first… | Enrollment / accrual |
| NCT03043989 | Cohorts of Docetaxel or Cabazitaxel in Combination With the Potent CYP3A4 Inhibitor,… | Phase 1 | terminated | Feb 6, 2017 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low accrual | Enrollment / accrual |
| NCT00464724 | 3T Perfluorocarbon-Filled Endorectal Magnetic Resonance Spectroscopic Imaging of Prostate | N/A | terminated | Apr 24, 2007 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT03256630 | Evaluation of a Blood Biomarker to Try and Distinguish Between the Presence or Absence of… | — | terminated | Aug 22, 2017 | Genomic Health®, Inc. | Business decision to discontinue development of the IsoPSA assay. | Sponsor / business decision |
| NCT02809846 | Quell Opioid Reduction and Pain Relief in Patients With Cancer | N/A | terminated | Jun 22, 2016 | Scripps Translational Science Institute | Unable to recruit enough participants. | Enrollment / accrual |
| NCT00937768 | Leuprolide Acetate or Goserelin Acetate Compared With Observation in Treating Patients… | Phase 2 | terminated | Jul 13, 2009 | Mayo Clinic | not stated | Not stated |
| NCT00582582 | Study of Docetaxel With Doxercalciferol or Placebo for Advanced Prostate Cancer | Phase 2 | terminated | Dec 28, 2007 | University of Wisconsin, Madison | Lack of drug supply for doxercalciferol for this study | Drug supply |
| NCT00585117 | Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | change in imaging priorities | Other (stated, no rule matched) |
| NCT01902823 | Effect of Cancer Nurse Navigators on Patient Outcomes | Phase 2 / Phase 3 | terminated | Jul 18, 2013 | University of Wisconsin, Madison | Clinicians were not offering the study to eligible potential subjects. | Other (stated, no rule matched) |
| NCT02689219 | Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors | Phase 2 | terminated | Feb 23, 2016 | Nabil Adra | lack of funding/ benefit | Funding |
| NCT01816048 | NaF Positron Emission Tomography/Computed Tomography (PET/CT)Imaging to Assess Treatment… | Phase 2 | terminated | Mar 21, 2013 | University of Wisconsin, Madison | Study supporter (Takeda) ended study drug for prostate cancer; enrollment ended prematurely. | Enrollment / accrual |
| NCT03293602 | MISOBOLD - Prostate Cancer Hypoxia Using BOLD MRI and 18F-MISO PET Imaging(MISOBOLD) | N/A | withdrawn | Sep 26, 2017 | University Hospital, Bordeaux | the team has changed. the new team did not have the perosnnel to set up the study | Other (stated, no rule matched) |
| NCT00415246 | Study to Evaluate a Subcutaneous Four Months Sustained-release Formulation of Triptorelin… | Phase 3 | terminated | Dec 22, 2006 | Ipsen | The preliminary data do not support the expected sustainable blood levels of triptorelin for a… | Other (stated, no rule matched) |
| NCT00444639 | Study to Assess the Non-inferiority of Pamorelin® 11,25mg SC Injected Versus Pamorelin®… | Phase 2 | terminated | Mar 8, 2007 | Ipsen | Low recruitment | Enrollment / accrual |
| NCT01313273 | Study of Lanreotide in Non Metastatic Castration-resistant Prostate Cancer Patients(POSEIDON) | Phase 3 | terminated | Mar 11, 2011 | Ipsen | Poor enrolment | Enrollment / accrual |
| NCT00702923 | CP-675,206 in Combination With Short Term Androgen Deprivation in Patients With Stage D0… | Phase 1 | terminated | Jun 20, 2008 | University of Wisconsin, Madison | Enrollment was halted prematurely due to slow accrual. | Enrollment / accrual |
| NCT01119118 | ZD4054 With Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) for… | Phase 2 | terminated | May 7, 2010 | University of Wisconsin, Madison | not stated | Not stated |
| NCT01533753 | Quality of Life Study Using Gabapentin Versus Venlafaxine in Treating Hot Flashes in… | Phase 2 | terminated | Feb 15, 2012 | University of Wisconsin, Madison | Slow accrual | Enrollment / accrual |
| NCT02758132 | Denosumab Plus Enzalutamide, Abiraterone and Prednisone Compared to Denosumab Plus… | Phase 2 | terminated | May 2, 2016 | University of Hawaii | Low accruals | Enrollment / accrual |
| NCT01562522 | Evaluation of the Effect of Psycho-oncological Intervention on Well-being of Patients…(EXPEDIENT) | Phase 2 | terminated | Mar 26, 2012 | Ipsen | Poor enrolment; only 6 subjects enrolled and they were all screen failures. | Enrollment / accrual |
| NCT00980993 | Quantification of Respiratory-induced Prostate Motion | — | withdrawn | Sep 21, 2009 | Oregon Health and Science University | Lack of enrollment. | Enrollment / accrual |
| NCT02538432 | Phase II Trial of EP4 Receptor Antagonist, AAT-007 (RQ-07; CJ-023,423) in Advanced Solid… | Phase 2 | withdrawn | Sep 2, 2015 | University of Maryland, Baltimore | PI No Longer at University of Maryland. Now at Fox Chase | Other (stated, no rule matched) |
| NCT02500901 | Enzalutamide and Niraparib in the Treatment of Metastatic Castrate-Resistant Prostate… | Phase 1 | terminated | Jul 17, 2015 | Paul Mathew, MD | Suspended by funder | Other (stated, no rule matched) |
| NCT01253642 | Phenelzine Sulfate and Docetaxel in Treating Patients With Prostate Cancer With… | Phase 2 | terminated | Dec 3, 2010 | OHSU Knight Cancer Institute | low enrollment | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Oct 19, 2020source: clinicaltrials