Clinical trial · Interventional
MISOBOLD - Prostate Cancer Hypoxia Using BOLD MRI and 18F-MISO PET Imaging
MISOBOLD - Prostate Cancer Hypoxia Using BOLD MRI and 18F-MISO PET Imagin
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): the team has changed. the new team did not have the perosnnel to set up the study
Summary
Brief summary (as posted)
This feasibility exploratory study objective is to assess the ability of combined MRI BOLD and 18F-MISO PET imaging to visualize tumor hypoxia compare to histological results obtained after radical prostatectomy in order to, in time, be able to identify patient with bad prognostic and to offer them the best therapeutic strategy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| F-MISO PET imaging | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- F-MISO PET imaging
- description
- F-MISO PET imaging will be added to the preoperative staging explorations of a patient with high risk prostate cancer candidate to radical prostatectomy. Patient will be selected during multidisciplinary meeting and urology consultation of Bordeaux and Toulouse university hospitals. Functional MRI imaging should be available before surgery. If patient consent to participate in the study, F-MISO PET imaging will be planed before prostatectomy. Results of this exam will not be considered for patient therapeutic management.
- interventionNames
- Device: F-MISO PET imaging
Primary outcomes (1)
- measure
- comparison between histological results and oxygenation quantitative values from MRI and PET exams
- timeFrame
- Inclusion, 1 month
- description
- Correlation study between anatomopatology data, product by prostatectomy anatomic piece, using HIF1-CAIX histological markers and: * on one hand PET FMISO uptake * on the other hand, MRI BOLD signal
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient above 18. * Prostate tumor with histological confirmed diagnosis and highly radiological suspected target on MRI * High risk patient : \>T2c grade, Glasgow score \> 7 and PSA \> 20ng/ml * Surgical treatment chosen during multidisciplinary meeting * ECOG ≤2 * Patient must have undergone MRI with BOLD sequence less than 6 month prior surgery * Member or beneficiary of a social security system. * Signed informed consent. Exclusion Criteria: * Patient included in another clinical study * Geographical, social or psychological reasons preventing patient from submitting to the study's medical monitoring * Patient deprive of liberty, adult subjects to legal protection or unable to give consent * Contraindications to MRI * Contraindication to gadolinium injection
References
Publications (0)
Data not yet available