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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,647 stopped studies mapped to Malignant Lung Neoplasm and descendants · 90% state a reason
Over the 1,647 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00131586 | Cisplatin, Carboplatin, and Oxaliplatin Interactions With Plasma Proteins | — | terminated | Aug 19, 2005 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT00492843 | Loading Dose or Standard Dose of Intravenous Ibandronate in Treating Patients With Lung… | Phase 4 | terminated | Jun 27, 2007 | Chinese Society of Lung Cancer | It is too difficult to recruit suitable patients. | Enrollment / accrual |
| NCT01525446 | Proton Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer | Early Phase 1 | terminated | Feb 3, 2012 | Massachusetts General Hospital | Slow accrual | Enrollment / accrual |
| NCT01565772 | Proton Radiation Therapy With Cisplatin and Etoposide Followed by Surgery in Stage III… | Phase 1 | terminated | Mar 29, 2012 | Massachusetts General Hospital | Slow accrual | Enrollment / accrual |
| NCT01029925 | Dichloroacetate (DCA) in Patients With Previously Treated Metastatic Breast or Non-Small… | Phase 2 | terminated | Dec 10, 2009 | Jonsson Comprehensive Cancer Center | DSMB determined, due to higher than expected risk/safety concerns, study should be closed. | Safety / toxicity |
| NCT02537561 | Talazoparib in Combination With Gemcitabine and Cisplatin in Patients With Advanced Solid… | Phase 1 | withdrawn | Sep 1, 2015 | Washington University School of Medicine | The pharmaceutical company did not want to follow through with support for the study. | Sponsor / business decision |
| NCT00812266 | Topotecan and Cisplatin Versus Etoposide and Carboplatin in 1st Line Treatment of… | Phase 3 | terminated | Dec 22, 2008 | Danish Oncological Lung Cancer Group | Slow accrual | Enrollment / accrual |
| NCT02470065 | Neoadjuvant Afatinib in Early Stage Non Small Cell Lung Cancer.(REMNANT) | Phase 2 | suspended | Jun 12, 2015 | European Organisation for Research and Treatment of Cancer - EORTC | Study never started | Other (stated, no rule matched) |
| NCT00345059 | The DISTAL-2 Study: Docetaxel Alone or in Combination in Second-line Treatment of…(DISTAL-2) | Phase 3 | terminated | Jun 27, 2006 | National Cancer Institute, Naples | slow accrual | Enrollment / accrual |
| NCT00299390 | Safety and Efficacy Study of a New Chemotherapy Agent to Treat Small Cell Lung Cancer | Phase 2 | terminated | Mar 6, 2006 | Bayer | Since only 1 of the first 10 subjects responded to the study treatment, it was decided to stop the… | Efficacy / futility |
| NCT00986284 | Epidermal Growth Factor Receptor (EGFR) Status Based Gefitinib Neoadjuvant Therapy in Non… | Phase 2 | suspended | Sep 29, 2009 | Tianjin Medical University Cancer Institute and Hospital | Lack of patients and some progressed disease soon after surgery | Other (stated, no rule matched) |
| NCT02629848 | Study of Motesanib (AMG 706) in Combination With Paclitaxel and Carboplatin for Advanced… | Phase 3 | terminated | Dec 14, 2015 | Takeda | Sponsor decision to terminate the study because the study did not meet the primary endpoint. | Sponsor / business decision |
| NCT01431378 | Pilot Study of Model Based Iterative Reconstruction Using 64-Slice(MBIR) | — | terminated | Sep 9, 2011 | GE Healthcare | Feasibility study, sufficient amount of data collected. | Other (stated, no rule matched) |
| NCT00988169 | Erlotinib and AT-101 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients With… | Phase 2 | terminated | Oct 2, 2009 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT01482572 | Feasibility of Mutational Analysis of Non-Small Cell Lung Cancer (NSCLC) Using Low-volume… | — | withdrawn | Nov 30, 2011 | Samsung Medical Center | not stated | Not stated |
| NCT01189435 | Erlotinib Re-Challenge for Recurrent EGFR-mutant Lung Cancer in Patients Who Previously… | Phase 2 | terminated | Aug 26, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01193868 | RO4929097 in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Recently… | Phase 2 | terminated | Sep 2, 2010 | National Cancer Institute (NCI) | Study drug production halted. | Other (stated, no rule matched) |
| NCT00006126 | Peripheral Stem Cell Transplantation in Treating Patients With Melanoma or Small Cell… | Phase 1 | withdrawn | Mar 8, 2004 | Northwestern University | Unable to accrue subjects. | Enrollment / accrual |
| NCT01159327 | Study of Sorafenib Maintenance in Patients With ED-SCLC After Response to Induction… | Phase 2 | terminated | Jul 9, 2010 | National Cancer Center, Korea | low enrolling participants | Enrollment / accrual |
| NCT01577212 | Individualized Dose Prescription in Advanced Stage Lung Cancer Patients Using Modern…(IDEAL-VMAT) | Phase 2 | terminated | Apr 13, 2012 | Radboud University Medical Center | Lack of accrual | Enrollment / accrual |
| NCT01348126 | Study of Ganetespib (STA-9090) + Docetaxel in Advanced Non Small Cell Lung Cancer(GALAXY) | Phase 2 / Phase 3 | terminated | May 5, 2011 | Synta Pharmaceuticals Corp. | not stated | Not stated |
| NCT01411098 | Radiation Therapy, Cisplatin, and Etoposide in Treating Patients With Non-small Cell Lung… | Phase 1 | terminated | Aug 8, 2011 | University of Washington | Low accrual | Enrollment / accrual |
| NCT02536495 | Selinexor and Docetaxel in Treating Patients With Recurrent or Metastatic Squamous Cell… | Phase 1 / Phase 2 | withdrawn | Sep 1, 2015 | Erin Bertino | PI decision due to funding support | Funding |
| NCT00530634 | Surgery, Gemcitabine, Cisplatin, and Radiation Therapy in Treating Patients With Stage II… | Phase 2 | terminated | Sep 17, 2007 | City of Hope Medical Center | Poor accrual | Enrollment / accrual |
| NCT00738881 | Pemetrexed Disodium or Erlotinib Hydrochloride as Second-Line Therapy in Treating…(MARVEL) | Phase 3 | terminated | Aug 21, 2008 | National Cancer Institute (NCI) | Slow accrual | Enrollment / accrual |
| NCT00768131 | A Study to Determine Whether EGFR Status by FISH Can Predict Results in Non Small Cell… | Phase 2 | withdrawn | Oct 7, 2008 | Eli Lilly and Company | not stated | Not stated |
| NCT00905801 | Computed Tomography (CT) Perfusion Imaging of Lung Cancer | N/A | terminated | May 21, 2009 | University of Pittsburgh | Co-PI left institution, PI not pursuing | Investigator |
| NCT00850577 | Ph II of a Novel Anti-angiogenic Agent in Combination With Chemotherapy for the Treatment… | Phase 2 | terminated | Feb 25, 2009 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00897143 | Identifying Early Lung Cancer Cells in Malignant Pleural Effusion Samples From Patients… | — | withdrawn | May 12, 2009 | Case Comprehensive Cancer Center | PI Left | Investigator |
| NCT00469976 | Enzastaurin, Carboplatin, and Gemcitabine With or Without Bevacizumab in Treating… | Phase 2 | withdrawn | May 7, 2007 | Eastern Cooperative Oncology Group | ECOG will not proceed with activation | Other (stated, no rule matched) |
| NCT00755157 | Metronomic Docetaxel and Bevacizumab in Patients With Small Cell Lung Cancer | Phase 2 | withdrawn | Sep 18, 2008 | University Hospital of Crete | not stated | Not stated |
| NCT02134886 | Erlotinib Hydrochloride in Treating Non-Small Cell Lung Cancer That is Metastatic or… | Phase 1 | terminated | May 9, 2014 | National Cancer Institute (NCI) | No Accrual | Enrollment / accrual |
| NCT00205413 | Surveillance For New Lung Primaries | — | terminated | Sep 20, 2005 | University of Wisconsin, Madison | low accrual | Enrollment / accrual |
| NCT00733252 | Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease | — | withdrawn | Aug 13, 2008 | Case Comprehensive Cancer Center | Low interest | Other (stated, no rule matched) |
| NCT01004419 | Trial of ZD6474 and Faslodex in Non-Small Cell Lung Cancer | Phase 1 | withdrawn | Oct 30, 2009 | University of Wisconsin, Madison | Support for investigational products has been withdrawn. | Other (stated, no rule matched) |
| NCT00923949 | Pioglitazone to Treat Adults Undergoing Surgery for Non-small Cell Lung Cancer | Phase 2 | terminated | Jun 18, 2009 | National Cancer Institute (NCI) | Study never published; terminated early due to low accrual. | Enrollment / accrual |
| NCT01946490 | Time Trends in Waiting Times of NSCLC Patients. | — | withdrawn | Sep 19, 2013 | Maastricht Radiation Oncology | Not subsidized, will not start in the near future | Other (stated, no rule matched) |
| NCT01193881 | RO4929097 and Erlotinib Hydrochloride in Treating Patients With Stage IV or Recurrent… | Phase 1 | terminated | Sep 2, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00749567 | Combination of Erlotinib and Bevacizumab as Second-line Treatment in Patients With… | Phase 2 | terminated | Sep 9, 2008 | Hellenic Oncology Research Group | Poor accrual | Enrollment / accrual |
| NCT02179567 | Docetaxel Plus Bevacizumab for Elderly Patients With Stage IV NSCLC | Phase 2 | terminated | Jul 2, 2014 | Hellenic Oncology Research Group | Terminated due to poor accrual | Enrollment / accrual |
| NCT01851161 | Prone Patient Positioning in Reducing Tumor Motion and Improving Breathing Reproduction… | — | terminated | May 10, 2013 | Virginia Commonwealth University | Data analysis completed | Other (stated, no rule matched) |
| NCT01501604 | BKM120 in Cancers With PIK3CA Activating Mutations | Phase 2 | withdrawn | Dec 29, 2011 | Massachusetts General Hospital | The study has been closed due to lack of accrual | Enrollment / accrual |
| NCT02250378 | Stereotactic Radiosurgery Followed by Wedge Resection in Treating Patients With Early… | N/A | withdrawn | Sep 26, 2014 | University of Southern California | No accrual | Enrollment / accrual |
| NCT00460317 | MONET1-MOtesanib NSCLC Efficacy and Tolerability Study | Phase 3 | terminated | Apr 13, 2007 | Amgen | Amgen discontinued the development of AMG706 because 20050201 did not meet its primary objective. | Other (stated, no rule matched) |
| NCT01057212 | Trial of Bevacizumab and Ixabepilone for Advanced or Metastatic Non-small Cell Lung… | Phase 2 | terminated | Jan 27, 2010 | Providence Health & Services | Lack of support from pharmaceutical collaborator. | Other (stated, no rule matched) |
| NCT01184287 | A Study Of Ranpirnase(Onconase®) To Pemetrexed Plus Carboplatin In Patients With… | Phase 2 | withdrawn | Aug 18, 2010 | Tamir Biotechnology, Inc. | Program discontinued | Other (stated, no rule matched) |
| NCT01408212 | Effectiveness of Additional Acupuncture Therapy for Lung Cancer Patients | N/A | terminated | Aug 3, 2011 | Korean Medicine Hospital of Pusan National University | low recruiting | Enrollment / accrual |
| NCT00050336 | Study of Lonafarnib in Combination With Paclitaxel and Carboplatin in Patients With… | Phase 3 | terminated | Dec 5, 2002 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00983047 | Nimotuzumab Plus Docetaxel in Chemotherapy-Refractory/Resistant Patients With Advanced… | Phase 2 | terminated | Sep 23, 2009 | Biotech Pharmaceutical Co., Ltd. | The sponsor decide to terminate | Other (stated, no rule matched) |
| NCT00704392 | Safety Study of XL647 and XL147 Administered in Combination Daily in Adults With Solid… | Phase 1 | withdrawn | Jun 24, 2008 | Exelixis | Study not initiated | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 26, 2016source: clinicaltrials