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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
848 stopped studies mapped to Malignant Large Intestinal Neoplasm and descendants · 91% state a reason
Over the 848 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02266849 | Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded… | Phase 3 | terminated | Oct 17, 2014 | Odense University Hospital | Insuficcient recruiting | Enrollment / accrual |
| NCT01815463 | Non-Invasive Prediction of Colorectal Neoplasia(NIPCON) | — | terminated | Mar 21, 2013 | Corporal Michael J. Crescenz VA Medical Center | Local PI did not submit annual renewal, still active in Detroit, not recruiting. | Enrollment / accrual |
| NCT00684229 | Regional Anesthesia in Colon Rectal Surgery | N/A | withdrawn | May 26, 2008 | The Cleveland Clinic | investigator could not identify any patients | Investigator |
| NCT01277120 | An Observational Study on The Correlation Between Time of Initiation of Avastin… | — | terminated | Jan 14, 2011 | Hoffmann-La Roche | Contract terminated with Site Management Organization | Other (stated, no rule matched) |
| NCT01969292 | Colometer - A Real Time Quality Improvement Feedback System for Screening Colonoscopy | N/A | terminated | Oct 25, 2013 | Christopher Andrews | Stage 1 Complete; Stage 2 and 3 not pursued | Other (stated, no rule matched) |
| NCT01457976 | A Survey on Attitudes on Financial Incentives | — | withdrawn | Oct 24, 2011 | University of Pennsylvania | protocol never approved by local IRB | Other (stated, no rule matched) |
| NCT01937715 | A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic… | Phase 1 / Phase 2 | terminated | Sep 9, 2013 | Pfizer | B2151007 was prematurely discontinued due to Pfizer's change in prioritization for the portfolio… | Safety / toxicity |
| NCT01322815 | A Pilot Trial of GI-4000 Plus Bevacizumab and Either FOLFOX or FOLFIRI | Phase 2 | terminated | Mar 25, 2011 | Georgetown University | Poor accrual rate | Enrollment / accrual |
| NCT01137162 | Clinical and Pathologic Studies of Patients Undergoing Treatment With EGFR Inhibitors | — | terminated | Jun 4, 2010 | Stanford University | Low Accrual | Enrollment / accrual |
| NCT01320683 | Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal… | Phase 2 | terminated | Mar 22, 2011 | City of Hope Medical Center | Slow accrual. | Enrollment / accrual |
| NCT01888965 | Maintenance Dovitinib for Colorectal and Pancreas Cancer | Phase 2 | terminated | Jun 28, 2013 | Georgetown University | Adverse Event issues. | Safety / toxicity |
| NCT02112240 | Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients | N/A | withdrawn | Apr 11, 2014 | University of Virginia | No accrual. New study opening with modified technique. | Enrollment / accrual |
| NCT01111292 | Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia | Phase 1 / Phase 2 | terminated | Apr 27, 2010 | National Cancer Institute (NCI) | The study was closed prematurely due to poor accrual. | Enrollment / accrual |
| NCT00767234 | Permission to Collect Blood Over Time for Research | — | terminated | Oct 7, 2008 | Stanford University | Accrual issues - Low Accrual | Enrollment / accrual |
| NCT00571740 | Cetuximab and Bevacizumab as First-Line Therapy Followed By Combination Chemotherapy and… | Phase 2 | withdrawn | Dec 12, 2007 | Alliance for Clinical Trials in Oncology | The study was not activated | Other (stated, no rule matched) |
| NCT01339000 | Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had… | Phase 2 | terminated | Apr 20, 2011 | National Cancer Institute (NCI) | Company supplying drug declared bankruptcy, thus there was no drug supply. | Drug supply |
| NCT00673322 | Trial of Second Generation Designer T Cells in Colorectal Carcinoma | Phase 1 | terminated | May 7, 2008 | Roger Williams Medical Center | This study will be incorporated into another study. | Other (stated, no rule matched) |
| NCT02202096 | A Pilot Randomized Trial of a Comprehensive Transitional Care Program for Colorectal… | N/A | withdrawn | Jul 28, 2014 | The University of Texas Health Science Center, Houston | Resources were not readily available to begin the study. | Other (stated, no rule matched) |
| NCT00216086 | Capecitabine + Irinotecan Followed by Combined Modality Capecitabine and Radiation in… | Phase 2 | terminated | Sep 22, 2005 | Gabi Chiorean, MD | Funding withdrawn | Funding |
| NCT01983371 | Diagnostic Accuracy of Ferumoxytol-Enhanced MRI for Detecting Lymph Node Metastases in… | N/A | withdrawn | Nov 14, 2013 | Scott Potenta, MD, PhD | not stated | Not stated |
| NCT02575508 | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With… | Phase 1 / Phase 2 | withdrawn | Oct 14, 2015 | Roswell Park Cancer Institute | drug supply issues | Drug supply |
| NCT01843452 | Phase II Study of Concomitant Intensity-modulated Radiotherapy Combined to Capecitabine,… | Phase 2 | terminated | Apr 30, 2013 | Centre Hospitalier Universitaire Vaudois | Poor recruitment | Enrollment / accrual |
| NCT01233544 | Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases(RAS01) | Phase 3 | terminated | Nov 3, 2010 | University of Aarhus | Insufficient recruitment | Enrollment / accrual |
| NCT01483638 | Axitinib as Maintenance Treatment in Patients With Metastatic CRC(TTD-11-01) | Phase 2 | terminated | Dec 1, 2011 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | The trial was prematurely closed due to lack of accrual | Enrollment / accrual |
| NCT01016028 | Chemotherapy-Induced Peripheral Neuropathy Survey | — | withdrawn | Nov 18, 2009 | M.D. Anderson Cancer Center | Study assessment tool development delayed. | Other (stated, no rule matched) |
| NCT00973193 | Preoperative Panitumumab and Radiotherapy in Rectal Cancer(PrePaRad) | Phase 2 | terminated | Sep 9, 2009 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | The intermediate analyses did not allowed to continue the clinical study. | Other (stated, no rule matched) |
| NCT02317731 | Effect of Use of Straw on Tolerability and Quality of Split Dose 4l-PEG Preparation | N/A | terminated | Dec 16, 2014 | Yale University | PI relocated | Other (stated, no rule matched) |
| NCT01858662 | Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected… | Phase 2 | terminated | May 21, 2013 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | due to poor recrutment | Other (stated, no rule matched) |
| NCT00865527 | Pilot Study of Colon Cancer Screening Tests | N/A | terminated | Mar 19, 2009 | Hamilton Health Sciences Corporation | Lack of ongoing funding | Funding |
| NCT02720926 | Study of TKI 258 in Combination With Xeloda and Oxaliplatin in Advanced Colorectal and… | Phase 1 | terminated | Mar 28, 2016 | National Cancer Centre, Singapore | Unafavourable toxicity profile | Safety / toxicity |
| NCT00131586 | Cisplatin, Carboplatin, and Oxaliplatin Interactions With Plasma Proteins | — | terminated | Aug 19, 2005 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT01157039 | A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis… | Phase 2 | withdrawn | Jul 5, 2010 | AHS Cancer Control Alberta | abandoned | Other (stated, no rule matched) |
| NCT00305643 | Celecoxib in Preventing Hand/Foot Syndrome Caused By Capecitabine With Metastatic Breast… | Phase 3 | terminated | Mar 22, 2006 | M.D. Anderson Cancer Center | Terminated due to low accrual. No data analyzed. | Enrollment / accrual |
| NCT00271011 | A Study of Mitomycin C, Irinotecan, and Cetuximab | Phase 2 | terminated | Dec 29, 2005 | University of Michigan Rogel Cancer Center | The study was discontinued due to the death of a co-investigator and a second co-investigator… | Investigator |
| NCT01186705 | Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type,… | Phase 2 | terminated | Aug 23, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01816659 | An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to… | Phase 1 | terminated | Mar 22, 2013 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00019747 | Surgery With or Without Thalidomide in Treating Patients With Recurrent or Metastatic… | Phase 2 | terminated | Jan 27, 2003 | National Institutes of Health Clinical Center (CC) | DSMB recommended closure of the protocol due to slow accrual. | Enrollment / accrual |
| NCT01856322 | Surgery Plus Sulindac or Surgery Alone for Advanced Colorectal Cancer | Phase 2 | terminated | May 17, 2013 | National Cancer Institute (NCI) | The trial was prematurely closed due to lack of accrual. | Enrollment / accrual |
| NCT01004159 | Cetuximab Plus Irinotecan in Colorectal Cancer Patients Who Progressed After Failure With… | Phase 2 | terminated | Oct 29, 2009 | Roswell Park Cancer Institute | former PI left institute | Investigator |
| NCT00717990 | Irinotecan, Capecitabine and Avastin for Metastatic Colorectal Cancer as Salvage Treatment | Phase 2 | terminated | Jul 18, 2008 | University Hospital of Crete | Poor Accrual | Enrollment / accrual |
| NCT00755118 | Lohp, 5-Fu/Lv and Bevacizumab, Alternative With Cpt-11, 5-Fu/Lv and Cetuximab In… | Phase 2 | terminated | Sep 18, 2008 | University Hospital of Crete | Due to poor Accrual | Enrollment / accrual |
| NCT01501604 | BKM120 in Cancers With PIK3CA Activating Mutations | Phase 2 | withdrawn | Dec 29, 2011 | Massachusetts General Hospital | The study has been closed due to lack of accrual | Enrollment / accrual |
| NCT00250835 | Combination of Oxaliplatin, Capecitabine, and Celecoxib With Concurrent Radiation for… | Phase 2 | terminated | Nov 8, 2005 | New Mexico Cancer Research Alliance | Low accrual | Enrollment / accrual |
| NCT00244348 | Hepatic Artery Infusion With Oxaliplatin | Phase 1 / Phase 2 | withdrawn | Oct 26, 2005 | Medical College of Wisconsin | Investigator has left institution | Investigator |
| NCT01062919 | Local Anesthetic Wound Infusion and Functional Recovery After Colon Surgery | N/A | terminated | Feb 4, 2010 | Franco Carli | Low recruitment rate - \>70% of colorectal procedures are done laparoscopically | Enrollment / accrual |
| NCT01300858 | A Study of the Safety and Biological Activity of Intraperitoneal (IP) EGEN-001… | Phase 1 / Phase 2 | terminated | Feb 23, 2011 | EGEN, Inc. | Sites could not enroll patients. | Enrollment / accrual |
| NCT00099346 | MK0457 (an Aurora Kinase Inhibitor) Study in Patients With Advanced Colorectal Cancer and… | Phase 1 | terminated | Dec 13, 2004 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00396487 | Tailored Treatment in Metastatic Colorectal Cancer | Phase 3 | terminated | Nov 7, 2006 | Vejle Hospital | Only one patient included as per Feb. 4, 2008. | Other (stated, no rule matched) |
| NCT01375816 | Liposome-encapsulated Irinotecan Hydrochloride PEP02 or Irinotecan Hydrochloride,…(PEPCOL) | Phase 2 | terminated | Jun 17, 2011 | GERCOR - Multidisciplinary Oncology Cooperative Group | efficacy interim analysis as per protocol | Efficacy / futility |
| NCT02162641 | Study to Determine the Feasibility of Sentinel Node Biopsy in Patients With Anal Cancer(R-SeNSAR) | — | withdrawn | Jun 13, 2014 | The Christie NHS Foundation Trust | The study was terminated early as it failed to recruit. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Oct 11, 2016source: clinicaltrials