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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
848 stopped studies mapped to Malignant Large Intestinal Neoplasm and descendants · 91% state a reason
Over the 848 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02611661 | Local Ablative Strategies After Endovascular Radioembolization(LASER) | Phase 1 | terminated | Nov 23, 2015 | Washington University School of Medicine | Principal Investigator left the university. | Investigator |
| NCT01978249 | A Randomized, Prospective, Multicenter Study for the Role of Primary Tumor Resection in… | N/A | terminated | Nov 7, 2013 | Yonsei University | Because of the difficulties of participant enrollment. | Enrollment / accrual |
| NCT03111823 | Exercise Program During Chemotherapy in Metastatic Colorectal Cancer | N/A | terminated | Apr 13, 2017 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT02654639 | Ph 2 Study of TAS-102 / Bevacizumab Maintenance Therapy Post Induction Chemotherapy in…(ALEXANDRIA) | Phase 2 | terminated | Jan 13, 2016 | Georgetown University | Principal investigator left the institution | Investigator |
| NCT01842971 | ALPPS (Liver Partition and Portal Vein Ligation) for Two-stage Hepatectomy for Colorectal… | Phase 3 | terminated | Apr 30, 2013 | Centre Hospitalier Universitaire, Amiens | Main reason: negative echo in the literature after the first publications. | Other (stated, no rule matched) |
| NCT00577109 | A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Patients With… | Phase 2 | withdrawn | Dec 19, 2007 | Hoffmann-La Roche | Study was cancelled before patient enrollment | Enrollment / accrual |
| NCT03073473 | Evaluation of the NantHealth GPS Cancer Test in Patients With Advanced Cancers | — | terminated | Mar 8, 2017 | Cota Inc. | Poor accrual | Enrollment / accrual |
| NCT00845039 | A Study of Irinotecan and Cetuximab With or Without IMC-A12 for Treatment of Participants…(FC-4) | Phase 2 | terminated | Feb 16, 2009 | Eli Lilly and Company | Study terminated early 22Feb2010 with only 4 participants due to business reasons. | Sponsor / business decision |
| NCT01197664 | Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer… | Phase 1 | terminated | Sep 9, 2010 | Wake Forest University Health Sciences | Study terminated due to funding issues | Funding |
| NCT02423954 | Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus)(NivoPlus) | Phase 1 / Phase 2 | terminated | Apr 22, 2015 | Western Regional Medical Center | Investigator no longer at site to enroll patients or write up data | Investigator |
| NCT03306966 | Assessing the Safety and Performance of the Endoscopic Linear Cutter Stapler and Reloads… | — | withdrawn | Oct 11, 2017 | Duomed | Design modification | Other (stated, no rule matched) |
| NCT00827580 | Eniluracil Hand Foot Syndrome | Phase 1 | terminated | Jan 23, 2009 | West Virginia University | not stated | Not stated |
| NCT00077233 | FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of… | Phase 3 | terminated | Feb 11, 2004 | Alliance for Clinical Trials in Oncology | Poor accrual | Enrollment / accrual |
| NCT01887509 | Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to…(TRaMA) | N/A | terminated | Jun 27, 2013 | IHU Strasbourg | Difficulties with patients recruitment, study acceptance and protocol implementation. | Enrollment / accrual |
| NCT01926769 | A Phase II Study to Determine the Safety and Efficacy of Second-line Treatment With… | Phase 2 | terminated | Aug 21, 2013 | Gachon University Gil Medical Center | Slow accrual rate | Enrollment / accrual |
| NCT03253185 | A Study of SC-007 in Subjects With Advanced Cancer | Phase 1 | terminated | Aug 17, 2017 | AbbVie | Benefit/Risk Imbalance | Other (stated, no rule matched) |
| NCT00663819 | Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses | N/A | terminated | Apr 22, 2008 | W.L.Gore & Associates | Per SAP | Other (stated, no rule matched) |
| NCT02577588 | Trial of Adoptive T Cell Therapy With Activated P53 Specific T Cells for Treatment of…(ATACC) | Phase 1 | terminated | Oct 16, 2015 | National Center for Tumor Diseases, Heidelberg | not feasible | Other (stated, no rule matched) |
| NCT02503631 | Stool Sample Collection Protocol for Development of Screening Test for Colorectal Cancer… | — | terminated | Jul 21, 2015 | Exact Sciences Corporation | Changes in development plan | Other (stated, no rule matched) |
| NCT02638909 | Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal… | Phase 2 | terminated | Dec 23, 2015 | Criterium, Inc. | Lack of Enrollment | Enrollment / accrual |
| NCT02365662 | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced… | Phase 1 | terminated | Feb 19, 2015 | AbbVie | Safety | Safety / toxicity |
| NCT03222089 | Phase II Trial of FOLFOXIGIL Versus FOLFOXIRI as First-line Therapy in Patients With mCRC | Phase 2 | withdrawn | Jul 19, 2017 | Fujian Cancer Hospital | Another study enrolling the similar group of patient are ongoing | Enrollment / accrual |
| NCT01919541 | Mechanistic Prehabilitation | N/A | withdrawn | Aug 9, 2013 | Franco Carli | difficulty in recruiting patients | Enrollment / accrual |
| NCT01284504 | Effect of Celecoxib on Perioperative Inflammatory Response in Colon Cancer | N/A | terminated | Jan 27, 2011 | Stanford University | low accrual rate; the only participant withdrew after signing consent | Enrollment / accrual |
| NCT03307603 | Yttrium-90 Radioembolization + Nivolumab for Liver + Extra-hepatic Metastases From… | Phase 1 / Phase 2 | withdrawn | Oct 11, 2017 | Case Comprehensive Cancer Center | Sponsor chose not to continue | Other (stated, no rule matched) |
| NCT01710293 | Intervention Protocol for Automated Point-of-Care Surveillance of Outpatient Delays in…(PACT CREATE 3) | N/A | withdrawn | Oct 19, 2012 | VA Office of Research and Development | Unable to obtain data needed to run the RCT; project never began recruitment | Enrollment / accrual |
| NCT02110953 | Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal… | Phase 1 | terminated | Apr 10, 2014 | Fox Chase Cancer Center | IRB study closure by investigator due to low enrollment | Investigator |
| NCT00388700 | A New Agent GM-CT-01 in Combination With 5-FU, Avastin and Leucovorin in Subjects With… | Phase 2 | withdrawn | Oct 17, 2006 | Galectin Therapeutics Inc. | Financing and re-organization | Funding |
| NCT02119676 | Study of Ruxolitinib in Colorectal Cancer Patients | Phase 2 | terminated | Apr 22, 2014 | Incyte Corporation | Substudy 1 was terminated for futility at interim analysis and Substudy 2 was terminated per… | Efficacy / futility |
| NCT01934179 | Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal… | — | terminated | Sep 4, 2013 | Fox Chase Cancer Center | Low Accrual Rate | Enrollment / accrual |
| NCT02163187 | Sacral Neuromodulation (SNM) With InterStimTM for Bowel Dysfunction Following Surgery for… | Phase 2 / Phase 3 | terminated | Jun 13, 2014 | Memorial Sloan Kettering Cancer Center | Study permanently closed due to low accrual | Enrollment / accrual |
| NCT02399631 | Enhanced Recovery Program After Laparoscopic Colon Cancer Surgery | N/A | terminated | Mar 26, 2015 | Kyungpook National University Hospital | not stated | Not stated |
| NCT02407561 | Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein… | — | terminated | Apr 3, 2015 | Castle Biosciences Incorporated | Futility - unable to secure sites and samples for participation | Efficacy / futility |
| NCT01729923 | A Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With…(ADAPT) | Phase 2 | terminated | Nov 20, 2012 | University of Washington | Funding ended | Funding |
| NCT01012362 | Study of Pazopanib and Ixabepilone in Patients With Solid Tumors | Phase 1 | terminated | Nov 13, 2009 | Masonic Cancer Center, University of Minnesota | PI left institution. | Investigator |
| NCT02182466 | German Colon Capsule Registry(DEKOR) | — | terminated | Jul 8, 2014 | Johann Wolfgang Goethe University Hospital | not stated | Not stated |
| NCT00226941 | A Phase 1-2 Trial of Cetuximab in Combination With Oxaliplatin, Capecitabine, and… | Phase 1 / Phase 2 | terminated | Sep 27, 2005 | George Albert Fisher | The response rate observed in the phase 1 portion of the study did not merit further evaluation in… | Other (stated, no rule matched) |
| NCT01279681 | Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older… | Phase 3 | terminated | Jan 19, 2011 | Alliance for Clinical Trials in Oncology | Slow accrual | Enrollment / accrual |
| NCT02057991 | Mindfulness-Based Exercise Video in Educating Hispanic/Latino Patients With Colorectal… | N/A | terminated | Feb 7, 2014 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT00903396 | Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy… | Phase 2 | terminated | May 18, 2009 | Alliance for Clinical Trials in Oncology | Slow accrual | Enrollment / accrual |
| NCT00625183 | Capecitabine, Oxaliplatin, Selenomethionine, and Radiation Therapy in Treating Patients… | Phase 2 | terminated | Feb 28, 2008 | Roswell Park Cancer Institute | Withdrawn due to poor/low accrual | Enrollment / accrual |
| NCT01606124 | Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer | Phase 2 | terminated | May 25, 2012 | Mayo Clinic | pending expiration of the supply of study agent. | Drug supply |
| NCT02630420 | Cetuximab and Savolitinib Treatment of Ras Wild-Type Colorectal Cancer | Phase 1 | withdrawn | Dec 15, 2015 | Yale University | The study never officially funded and therefore never began. | Funding |
| NCT02774512 | Predictive Biomarkers of Biological Activity and Efficacy of Nilotinib on ZAK Target in…(ZAK-0) | Early Phase 1 | withdrawn | May 17, 2016 | Institut Bergonié | none participant has been enrolled and recruited during the first year after competent autority… | Enrollment / accrual |
| NCT03007771 | Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) Used for Mild… | Phase 1 | withdrawn | Jan 2, 2017 | Washington University School of Medicine | Decision was made to not go forward with the study | Other (stated, no rule matched) |
| NCT00003485 | Antineoplaston Therapy in Treating Patients With Metastatic or Unresectable Colon Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT02615574 | A Study of Type-1 Polarized Dendritic Cell (αDC1) Vaccine in Combination With… | Phase 2 | withdrawn | Nov 26, 2015 | Pawel Kalinski | Due to inadequate supply of drug | Drug supply |
| NCT02542436 | Avastin (Bevacizumab) in the Treatment of Metastatic Colorectal Cancer in Normal Clinical… | — | withdrawn | Sep 7, 2015 | Hoffmann-La Roche | not stated | Not stated |
| NCT02538627 | Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib | Phase 1 | terminated | Sep 2, 2015 | Merrimack Pharmaceuticals | Sponsor decision | Sponsor / business decision |
| NCT02609451 | Closure of Protective Ileostomy 2 vs. 12 Weeks After TME(Closure2vs12) | N/A | terminated | Nov 20, 2015 | Kantonsspital Liestal | Evidence of bad outcome after interims analysis | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 16, 2018source: clinicaltrials