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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
110 stopped studies mapped to Malignant Intracranial Neoplasm and descendants · 91% state a reason
Over the 110 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API ().
reasonMatches| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT04730349 | A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in…(PIVOT IO 020) | Phase 1 / Phase 2 | terminated | Jan 29, 2021 | Bristol-Myers Squibb | Business objectives have changed | Sponsor / business decision |
| NCT02880111 | Rates DMBT1 ( Glycoprotein) in Sputum of CF Patients With Pseudomonas Aeruginosa(DMBT1) | — | terminated | Aug 26, 2016 | University Hospital, Lille | only one patient was included | Other (stated, no rule matched) |
| NCT02885324 | Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in… | Phase 2 | terminated | Aug 31, 2016 | Indiana University | Failure to meet accrual goals. | Enrollment / accrual |
| NCT01884740 | Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial… | Phase 1 / Phase 2 | terminated | Jun 24, 2013 | Weill Medical College of Cornell University | The study was prematurely closed in December 2021 due to low accrual. | Enrollment / accrual |
| NCT04460495 | Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI | N/A | terminated | Jul 7, 2020 | Jonsson Comprehensive Cancer Center | insufficient accrual | Enrollment / accrual |
| NCT02212574 | Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt… | Early Phase 1 | terminated | Aug 8, 2014 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Participant relapses led to abrupt stop of study. | Other (stated, no rule matched) |
| NCT01058850 | Phase I Rindopepimut After Conventional Radiation in Children w/ Diffuse Intrinsic… | Phase 1 | terminated | Jan 29, 2010 | Paul Graham Fisher | Resources can be better spent on higher enrolling studies | Enrollment / accrual |
| NCT01110876 | Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme… | Phase 1 / Phase 2 | terminated | Apr 27, 2010 | M.D. Anderson Cancer Center | Unanticipated Toxicities | Safety / toxicity |
| NCT04854044 | ONC201 and Radiation Therapy Before Surgery for the Treatment of Recurrent Glioblastoma | Phase 1 | withdrawn | Apr 22, 2021 | Jonsson Comprehensive Cancer Center | The P.I. is not prepared to move forward at this thime | Other (stated, no rule matched) |
| NCT02255461 | Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or… | Phase 1 | terminated | Oct 2, 2014 | Pediatric Brain Tumor Consortium | Data for the primary objectives is complete and the MTD identified in Stratum II. | Other (stated, no rule matched) |
| NCT00592865 | Risk Factors for Adult-Onset Brain Tumors | — | terminated | Jan 14, 2008 | Vanderbilt University Medical Center | not stated | Not stated |
| NCT02758366 | Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse… | Phase 2 | terminated | May 2, 2016 | Meyer Children's Hospital IRCCS | Study was terminated due to high heterogeneity of enrolled patients | Enrollment / accrual |
| NCT02607124 | A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy | Phase 1 / Phase 2 | terminated | Nov 17, 2015 | Children's Hospital Medical Center, Cincinnati | A competing trial was opened for patient population with combination of ribociclib and everolimus. | Other (stated, no rule matched) |
| NCT01987596 | Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After… | Phase 3 | terminated | Nov 19, 2013 | Barbara Ann Karmanos Cancer Institute | not stated | Not stated |
| NCT04270461 | NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors | Phase 1 | withdrawn | Feb 17, 2020 | Jiujiang University Affiliated Hospital | Study is withdrawn because of administrative reasons | Other (stated, no rule matched) |
| NCT03629964 | Study to Develop Head Stabilizer for Use During Brain Radiation Therapy | N/A | withdrawn | Aug 14, 2018 | University of Chicago | PI left site. | Investigator |
| NCT01400672 | Imiquimod/Brain Tumor Initiating Cell (BTIC) Vaccine in Brain Stem Glioma | Phase 1 | terminated | Jul 22, 2011 | Masonic Cancer Center, University of Minnesota | Treatment ineffective; Extreme toxicity | Safety / toxicity |
| NCT02684071 | Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive… | Phase 2 | terminated | Feb 17, 2016 | Nicklaus Children's Hospital f/k/a Miami Children's Hospital | Lack of additional funding; patients (3) no longer receiving intervention. | Funding |
| NCT04051047 | Gemcitabine in Newly-Diagnosed Diffuse Midline Glioma | Early Phase 1 | withdrawn | Aug 9, 2019 | University of Michigan Rogel Cancer Center | Withdrawn by Principal Investigator | Investigator |
| NCT02692898 | Biomarker Analysis of Central Nervous System Tumors | — | terminated | Feb 26, 2016 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02689336 | Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory… | Phase 2 | withdrawn | Feb 23, 2016 | Washington University School of Medicine | Could not recruit any participants | Enrollment / accrual |
| NCT01182350 | Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG) | Phase 2 | terminated | Aug 16, 2010 | Karen D. Wright MD | Per design: Stop if fewer than 3 cohorts by molecular classification were with 10 participants or… | Enrollment / accrual |
| NCT01065805 | A Study to Demonstrate the Safety and Preliminary Efficacy of 18F-FLT in Patients With… | Phase 1 / Phase 2 | terminated | Feb 9, 2010 | AHS Cancer Control Alberta | Retirement of former Qualified Investigator and lack of resources to complete study | Investigator |
| NCT01014767 | Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid… | Phase 3 | terminated | Nov 17, 2009 | Tufts Medical Center | PI departure from coordinating institution | Other (stated, no rule matched) |
| NCT03632317 | A Study of Panobinostat in Combination With Everolimus for Children and Young Adults With… | Phase 2 | withdrawn | Aug 15, 2018 | University of Michigan Rogel Cancer Center | low accrual | Enrollment / accrual |
| NCT01601184 | Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in… | Phase 1 / Phase 2 | terminated | May 17, 2012 | Centre Leon Berard | The number of successes is not reached at the end of first stage of the phase II. The study is… | Other (stated, no rule matched) |
| NCT00031590 | Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly… | Phase 2 | terminated | Jan 27, 2003 | Children's Hospital of Philadelphia | The study was terminated prematurely due to slow accrual. | Enrollment / accrual |
| NCT02395692 | Methoxyamine and Temozolomide in Treating Patients With Recurrent Glioblastoma | Phase 2 | terminated | Mar 24, 2015 | National Cancer Institute (NCI) | Pre-specified response criteria not met to proceed to next stage of study. | Other (stated, no rule matched) |
| NCT02213536 | Investigating the Efficacy of Hair Sparing Radiotherapy Treatment to the Whole Brain.(SPARE) | — | terminated | Aug 11, 2014 | HCA International Limited | Poor recruitment and follow up | Enrollment / accrual |
| NCT01048060 | Consent for Obtaining Additional Bone Marrow Specimens at Time of Diagnostic Bone Marrow… | — | terminated | Jan 13, 2010 | Stanford University | Business Decision | Sponsor / business decision |
| NCT02796729 | CEST- Glucose Enhanced MRI for Metastatic Brain Tumours | Phase 2 | terminated | Jun 13, 2016 | British Columbia Cancer Agency | Not enough enrollment | Enrollment / accrual |
| NCT01234805 | Yoga Therapy in Treating Patients With Malignant Brain Tumors | N/A | terminated | Nov 4, 2010 | Wake Forest University Health Sciences | Slow Accruals | Enrollment / accrual |
| NCT01987193 | Feasibility Study of Tumor Blood Flow Measurement by Detection of Positron Activation… | — | terminated | Nov 19, 2013 | University of Florida | Slow accrual; funding stopped | Enrollment / accrual |
| NCT02332889 | Phase I/II: Decitabine/Vaccine Therapy in Relapsed/Refractory Pediatric High Grade… | Phase 1 / Phase 2 | terminated | Jan 7, 2015 | University of Louisville | Transition to a different immunotherapy strategy in the future at our institution | Sponsor / business decision |
| NCT01740570 | Phase I/II Cabazitaxel for Recurrent Malignant Glioma | Phase 1 / Phase 2 | withdrawn | Dec 4, 2012 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT02348255 | NovoTTF-100A With Bevacizumab and Carmustine in Treating Patients With Glioblastoma… | Phase 2 | withdrawn | Jan 28, 2015 | University of California, Davis | Poor Accrual | Enrollment / accrual |
| NCT03013387 | Dosimetry Guided PRRT With 90Y-DOTATOC | Phase 2 | withdrawn | Jan 6, 2017 | Sue O'Dorisio | This project has undergone a significant amount of updates and has been resubmitted under IRB#… | Other (stated, no rule matched) |
| NCT02194452 | Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young… | N/A | withdrawn | Jul 18, 2014 | Sue O'Dorisio | not stated | Not stated |
| NCT02967380 | Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in… | N/A | terminated | Nov 18, 2016 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT02175745 | 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or… | N/A | terminated | Jun 26, 2014 | Erik Mittra | Re-evaluate indication with the referring physicians | Other (stated, no rule matched) |
| NCT01902771 | Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors | Phase 1 | terminated | Jul 18, 2013 | Edward Ziga | Lack of Accrual | Enrollment / accrual |
| NCT01113463 | TPI 287 in Patients With Recurrent Glioblastoma Multiforme | Phase 2 | terminated | Apr 30, 2010 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT02047747 | A Phase II Study of Dacomitinib in Progressive Brain Metastases | Phase 2 | terminated | Jan 28, 2014 | David Piccioni, M.D., Ph.D | slow enrollment | Enrollment / accrual |
| NCT02370563 | PET Imaging of Intracranial Cancers With 18F-FSPG | Phase 1 | terminated | Feb 25, 2015 | Lantheus Biosciences Ltd. | Business decision | Sponsor / business decision |
| NCT01105702 | Temodar (Temozolomide), Bevacizumab, Lithium and Radiation for High Grade Glioma | Phase 2 | terminated | Apr 16, 2010 | NYU Langone Health | Due to slow accrual | Enrollment / accrual |
| NCT02031965 | Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade… | Phase 1 | terminated | Jan 9, 2014 | Pediatric Brain Tumor Consortium | not stated | Not stated |
| NCT01445691 | More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery | Phase 2 | withdrawn | Oct 4, 2011 | Constantinos Hadjipanayis | not stated | Not stated |
| NCT02521090 | EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory… | Phase 1 / Phase 2 | withdrawn | Aug 13, 2015 | Barbara Ann Karmanos Cancer Institute | Due to lack of funding and a primary co-investigator of the trial leaving the institution. | Investigator |
| NCT01861990 | Valproic Acid in Childhood Progressive Brain Tumors | Phase 1 | withdrawn | May 24, 2013 | Medical University of South Carolina | Feasibility of the trial was proven to be absent. | Other (stated, no rule matched) |
| NCT01100658 | Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors | N/A | terminated | Apr 9, 2010 | University of Minnesota | Due to slow accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Mar 24, 2023source: clinicaltrials