Clinical trial · Interventional
Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI
Quantifying Tumor Respiration Using Oxygen-Enhanced Molecular MRI
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): insufficient accrual
Summary
Brief summary (as posted)
This trial looks to study the safety and feasibility of using oxygen-enhanced molecular MRI to understand how cancer cells use oxygen differently than normal cells. Cancer cells tend to utilize (or not utilize) oxygen differently than normal cells. By using the oxygen-enhanced molecular MRI, researchers will be able to create spatial "maps" depicting areas of abnormal oxygen utilization unique to cancer. This type of information may be useful for diagnosing new cancers, understanding various "subtypes" of cancer that might utilize oxygen differently, or this information may be useful for evaluating new drugs that impact cancer metabolism.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Brain Neoplasm | Malignant Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Arterial Spin Labeling Magnetic Resonance Imaging | Procedure | — | UNRESOLVED |
| Oxygen-weighted SAGE-EPI | Procedure | — | UNRESOLVED |
| pH-Weighted amine CEST | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Feasibility (ASL,pH-Weighted amine CEST, O2-Weighted SAGE-EPI)
- description
- Participants undergo ASL perfusion, pH-weighted amine CEST, and oxygen-weighted SAGE-EPI , while breathing normal room air (21% oxygen). Patients then undergo another ASL perfusion, pH-weighted amine CEST, and oxygen-weighted SAGE-EPI while breathing medical grade air (100% oxygen). Total ASL perfusion, pH-weighted amine CEST, and oxygen-weighted SAGE-EPI imaging scan time is 60 minutes.
- interventionNames
- Procedure: Arterial Spin Labeling Magnetic Resonance Imaging
- Procedure: pH-Weighted amine CEST
- Procedure: Oxygen-weighted SAGE-EPI
Primary outcomes (3)
- measure
- Change in pH-weighted amine CEST MRI to measure tumor acidity (MTRasym at 3ppm) before/after oxygen enrichment
- timeFrame
- Baseline and two hours after Oxygen enrichment
- description
- Will be measured by voxel-wise t-tests via analysis of functional NeuroImages (AFNI) software between the average R2' and MTRasym during normal room air and medical grade air.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Healthy volunteers will include persons who at the time of scans do not present with known neurological conditions that might impact tissue imaging results * Patient participants should have suspected or pathology-confirmed diagnosis of a brain tumor (any histological subtype including brain metastases) * All participants must be able to obtain an MRI scan and must be able to safely breathe high concentrations of oxygen Exclusion Criteria: * Participants with contraindications to MRI including metal implants * Participants who are deemed not able to or not safe to breath high concentrations of oxygen
References
Publications (0)
Data not yet available