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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
691 stopped studies mapped to Malignant Head and Neck Neoplasm and descendants · 92% state a reason
Over the 691 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00934739 | A Study of High-Risk Oral Cavity Cancer | Phase 2 / Phase 3 | terminated | Jul 8, 2009 | National Health Research Institutes, Taiwan | not stated | Not stated |
| NCT01219673 | Symptom Burden in Head and Neck Cancer | Phase 1 / Phase 2 | terminated | Oct 13, 2010 | M.D. Anderson Cancer Center | Low accrual. | Enrollment / accrual |
| NCT00525135 | Valproic Acid (Depakote ER) in Patients With Advanced Thyroid Cancer | Phase 2 | terminated | Sep 5, 2007 | University of California, San Francisco | PI left university and study was halted prematurely. No data was analyzed. | Investigator |
| NCT00354523 | Imatinib in Combination With Dacarbazine and Capecitabine in Medullary Thyroid Carcinoma | Phase 1 / Phase 2 | terminated | Jul 20, 2006 | M.D. Anderson Cancer Center | Study closed following Phase I portion, insufficient activity to continue to Phase II. | Other (stated, no rule matched) |
| NCT01587820 | Intra-arterial Versus Intravenous Cisplatin, Combined With Radiation, for Oral Cavity and… | Early Phase 1 | terminated | Apr 30, 2012 | Southern Illinois University | lack of enrollment | Enrollment / accrual |
| NCT02013453 | A Phase II Trial of Proton Pump Inhibitors With Chemotherapy in Patients With Metastatic… | Phase 2 | withdrawn | Dec 17, 2013 | University of Michigan Rogel Cancer Center | Lack of funding | Funding |
| NCT02085525 | A Randomized Comparative Study of a Weekly Versus Every Other Week Nurse Practitioner-led… | N/A | withdrawn | Mar 13, 2014 | University of Michigan Rogel Cancer Center | Lack of funding. | Funding |
| NCT01254734 | Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck… | N/A | terminated | Dec 7, 2010 | City of Hope Medical Center | The study will be rewritten as a data registry study | Other (stated, no rule matched) |
| NCT01549379 | Dynamic Contrast Enhanced Computed Tomography (CT) for Head and Neck Cancer | N/A | terminated | Mar 9, 2012 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Poor Accrual | Enrollment / accrual |
| NCT01718223 | Photodynamic Therapy Using Temoporfin Before Surgery in Treating Patients With Recurrent… | N/A | withdrawn | Oct 31, 2012 | Roswell Park Cancer Institute | implementation issues | Other (stated, no rule matched) |
| NCT01305772 | Identification of Gene Expression Signature for Panitumumab Sensitivity in Untreated…(TOP0901) | Phase 2 | terminated | Mar 1, 2011 | Neal Ready | This study was terminated for low accrual. | Enrollment / accrual |
| NCT01682031 | Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck… | Phase 2 | terminated | Sep 10, 2012 | Roswell Park Cancer Institute | Due to a lack of funding | Funding |
| NCT01403259 | SOX as Salvage Treatment in Nasopharyngeal Carcinoma | Phase 2 | terminated | Jul 27, 2011 | Fudan University | poor accrual of eligible patients | Enrollment / accrual |
| NCT01175499 | Concordance of Two Endoscopic Procedures for Diagnosis of Carcinoma of the Upper…(TNFE-NBI) | N/A | withdrawn | Aug 4, 2010 | University of California, San Francisco | Unable to obtain funding to continue recruitment; no accrual | Enrollment / accrual |
| NCT00911326 | Evaluation of Sentinel Lymph Nodes in Head and Neck Squamous Cell Carcinoma | Phase 3 | terminated | Jun 1, 2009 | Navidea Biopharmaceuticals | The trial was terminated early based on an interim review by the Data and Safety Monitoring… | Safety / toxicity |
| NCT00530088 | Photodynamic Therapy Using Porfimer Sodium in Treating Patients With Recurrent Mouth or… | N/A | terminated | Sep 17, 2007 | Roswell Park Cancer Institute | new competing studies | Other (stated, no rule matched) |
| NCT00002947 | Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer | Phase 1 | terminated | Mar 26, 2004 | Yale University | not stated | Not stated |
| NCT00616590 | Insomnia in Patients Undergoing Chemotherapy and Radiation Therapy for Head and Neck… | — | withdrawn | Feb 15, 2008 | Vanderbilt University | not stated | Not stated |
| NCT01360827 | EMD 1201081 + 5-FU + Cisplatin + Cetuximab in Subjects With Recurrent / Metastatic… | Phase 1 | terminated | May 26, 2011 | Merck KGaA, Darmstadt, Germany | Study terminated due to potential safety concerns in combination with platinum-based therapies | Safety / toxicity |
| NCT00507429 | Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid…(FACT) | Phase 2 / Phase 3 | terminated | Jul 26, 2007 | Mateon Therapeutics | Low rate of subject accrual | Enrollment / accrual |
| NCT01741597 | Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With… | Phase 1 | withdrawn | Dec 5, 2012 | City of Hope Medical Center | PI chose to close the study | Other (stated, no rule matched) |
| NCT00184028 | Combination of Taxotere and Oxaliplatin in Squamous Cell Carcinoma of the Head and Neck | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT01701349 | Fosbretabulin or Placebo in Combination With Carboplatin/Paclitaxel in Anaplastic Thyroid…(FACT2) | Phase 3 | withdrawn | Oct 5, 2012 | Mateon Therapeutics | Expected inability to recruit study participants in a reasonable amount of time. | Enrollment / accrual |
| NCT00115739 | Trial Evaluating Gleevec in Patients With Anaplastic Thyroid Carcinoma | Phase 2 | terminated | Jun 24, 2005 | University of Michigan Rogel Cancer Center | Study was closed early due to slow accrual | Enrollment / accrual |
| NCT00004227 | Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III or Stage… | Phase 3 | terminated | Jan 27, 2003 | University of Alabama at Birmingham | not stated | Not stated |
| NCT00095693 | Sorafenib Tosylate in Treating Patients With Locally Advanced, Metastatic, or Locally… | Phase 2 | terminated | Nov 8, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01728480 | Entolimod in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer… | Phase 1 | withdrawn | Nov 19, 2012 | Roswell Park Cancer Institute | Financial Sponsor requested termination | Funding |
| NCT01370876 | Efficacy and Safety Study of Oxaliplatin/5-FU in Patients With Recurrent or Metastatic… | Phase 2 | terminated | Jun 10, 2011 | Nang Kuang Pharmaceutical Co., Ltd. | company policy | Sponsor / business decision |
| NCT00095641 | S0225 Capecitabine in Treating Patients Who Have Undergone Surgery for Locally Recurrent… | Phase 2 | withdrawn | Nov 8, 2004 | SWOG Cancer Research Network | no longer studying this disease site | Other (stated, no rule matched) |
| NCT00574860 | EN3285 for the Prevention or Delay of Oral Mucositis in Patients With Head and Neck Cancer | Phase 3 | terminated | Dec 17, 2007 | Endo USA Inc., a Keenova Therapeutics Company | Additional research | Other (stated, no rule matched) |
| NCT00006106 | ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck… | Phase 1 | withdrawn | Apr 29, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00113399 | Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With… | Phase 3 | terminated | Jun 8, 2005 | Radiation Therapy Oncology Group | Terminated early due to low accrual. | Enrollment / accrual |
| NCT00906360 | Sunitinib, Cetuximab, and Radiation Therapy in Treating Patients With Locally Advanced or… | Phase 1 | terminated | May 21, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01412749 | TEST: Registry for Endoscopic Head and Neck Surgery(TEST) | — | terminated | Aug 9, 2011 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT00908024 | Combination Study of BMS-754807 and Erbitux® in Subjects With Advanced or Metastatic… | Phase 1 / Phase 2 | terminated | May 25, 2009 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00062387 | Perifosine in Treating Patients With Recurrent or Metastatic Head and Neck Cancer | Phase 2 | terminated | Jun 6, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00954837 | Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid Cancer(CYT2THYR) | N/A | withdrawn | Aug 7, 2009 | Assistance Publique - Hôpitaux de Paris | administrative delays too long | Other (stated, no rule matched) |
| NCT00608751 | A Feasibility Study of Adaptive Intensity-Modulated Radiation Therapy(IMRT) | Early Phase 1 | terminated | Feb 6, 2008 | Washington University School of Medicine | Lack of accrual and software issues | Enrollment / accrual |
| NCT01736878 | Efficacy and Safety Study of Sorafenib to Treat Advanced Medullary Thyroid Carcinoma(SUMMIT) | Phase 2 | withdrawn | Nov 29, 2012 | Eanm Research Ltd | Study was withdrawn due to unanticipated hassle in patient recruitment. | Enrollment / accrual |
| NCT01674374 | Botanical Therapy in Treating Mucositis in Patients With Head and Neck Cancer Who Have… | Phase 2 | withdrawn | Aug 28, 2012 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT01427205 | Phase II Study of Cetuximab With or Without OSI-906 in Head and Neck Squamous Cell… | Phase 2 | withdrawn | Sep 1, 2011 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00898430 | Biomarkers in Predicting Response to Treatment in Patients With Newly Diagnosed Stage III… | — | terminated | May 12, 2009 | Vanderbilt-Ingram Cancer Center | Study closed prematurely upon PI's departure | Other (stated, no rule matched) |
| NCT00898742 | Gene and Protein Expression Patterns in Predicting Response to Cetuximab in Patients With… | — | terminated | May 12, 2009 | Vanderbilt-Ingram Cancer Center | study closed prematurely upon PI's departure from VICC | Other (stated, no rule matched) |
| NCT00126607 | Trastuzumab in Treating Patients With Metastatic or Recurrent Salivary Gland Cancer | Phase 2 | terminated | Aug 4, 2005 | National Cancer Institute (NCI) | Poor accrual. | Enrollment / accrual |
| NCT01058408 | RAD001 With Weekly Cisplatin and Radiation Therapy in Patients With Locally Advanced Head… | Phase 1 | terminated | Jan 28, 2010 | Dana-Farber Cancer Institute | not stated | Not stated |
| NCT00033449 | Gefitinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00081211 | Intratumoral PV701 in Treating Patients With Advanced or Recurrent Unresectable Squamous… | Phase 1 | terminated | Apr 8, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01015664 | Combination of Cisplatin, Cetuximab and Temsirolimus in Recurrent or Metastatic Squamous… | Phase 1 / Phase 2 | terminated | Nov 18, 2009 | University of Tennessee Cancer Institute | not stated | Not stated |
| NCT01506427 | A Study of [F-18]HX4 (PET Imaging)Evaluated in Head and Neck Cancer Patients | Phase 1 / Phase 2 | withdrawn | Jan 10, 2012 | Siemens Molecular Imaging | not stated | Not stated |
| NCT00527982 | Celecoxib as Adjuvant Biologic Therapy in Patients With Head and Neck and Lung Cancer | Phase 2 | terminated | Sep 11, 2007 | M.D. Anderson Cancer Center | Termination due to poor accrual. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 25, 2015source: clinicaltrials