A Study of [F-18]HX4 (PET Imaging)Evaluated in Head and Neck Cancer Patients

Inclusion Criteria:

* Patient is \>18 years and male or female of any race / ethnicity.
* Patient or patient's legally acceptable representative provides written inform consent Patient is willing and able to comply with protocol procedures.
* Patient has newly diagnosed histologically confirmed squamous cell carcinoma of the head and/or neck whose primary origin is from the oral cavity, oropharynx, hypopharynx, larynx or nasopharynx.
* Patient is scheduled to have or already has had a clinical \[F-18\]FDG PET/CT scan prior (recommended to be within 14 days prior) to the \[F-18\]HX4 PET/CT scan.
* Patient has a primary tumor ≥ 2.0 cm in longest axis measured by CT or MR; or lymph node ≥ 2.0 cm in shortest axis measured by CT or MR if primary tumor \< 2 cm on CT or MR; CT may be part of required \[F-18\]FDG PET/CT scan or a separate pre-surgery CT scan.
* Patient is scheduled to undergo complete tumor resection within 7 days for his/her cancer care after the \[F-18\]HX4 PET/CT scan is performed.
* Patient has not had nor will have neoadjuvant treatment, including radiation and chemotherapy, prior to patient's planned tumor resection.

Exclusion Criteria:

* Female patient is pregnant or nursing.
* Patient is not capable of remaining still for duration of imaging procedure (\~ 4 hours).
* Patient has undergone an investigative, radioactive research procedure within 7 days prior to study participation, or is scheduled to undergo such a procedure during the study participation period.
* Patient has chronic renal function failure or is on renal dialysis
* Patient has any other condition or personal circumstance that, in the judgment of the investigator, might interfere with the collection of complete data.