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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
691 stopped studies mapped to Malignant Head and Neck Neoplasm and descendants · 92% state a reason
Over the 691 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02022293 | Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From… | Phase 2 | suspended | Dec 27, 2013 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Enrollment target could not be achieved. | Enrollment / accrual |
| NCT00003489 | Antineoplaston Therapy in Treating Patients With Advanced Head and Neck Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT00570674 | Abraxane in Combination With Carboplatin, Erbitux and IMRT for Locally Advanced Squamous… | Phase 1 / Phase 2 | terminated | Dec 11, 2007 | Dana-Farber Cancer Institute | The study did not continue to phase II due to the importance of HPV status as a prognostic factor… | Other (stated, no rule matched) |
| NCT02298595 | Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma | Phase 1 / Phase 2 | withdrawn | Nov 24, 2014 | Julie E. Bauman, MD, MPH | not stated | Not stated |
| NCT00400205 | Study of Induction Docetaxel, Cisplatin and 5-Fluorouracil | Phase 2 | terminated | Nov 16, 2006 | Emory University | Safety reasons | Safety / toxicity |
| NCT02068157 | Interstitial Photodynamic Therapy in Treating Patients With Recurrent Head and Neck Cancer | Phase 2 | terminated | Feb 21, 2014 | Roswell Park Cancer Institute | Study no longer has an active IDE | Other (stated, no rule matched) |
| NCT00965003 | MRI Laryngeal Imaging With a Surface Coil | Early Phase 1 | terminated | Aug 25, 2009 | Stanford University | Absence of key personnel to conduct study | Other (stated, no rule matched) |
| NCT02831179 | Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and… | Phase 1 | withdrawn | Jul 13, 2016 | Vanderbilt-Ingram Cancer Center | Loss of funding support | Funding |
| NCT02211027 | Biological Vaccine: Semi-allogeneic Human Fibroblasts (MRC-5) Transfected With DNA | Phase 1 | withdrawn | Aug 7, 2014 | Robert Ferris | not stated | Not stated |
| NCT02538627 | Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib | Phase 1 | terminated | Sep 2, 2015 | Merrimack Pharmaceuticals | Sponsor decision | Sponsor / business decision |
| NCT02437513 | NewBreez for Airway Protection in Head and Neck Cancer Patients With Chronic Aspiration | — | terminated | May 7, 2015 | ProTiP Medical | Recruitment rates too low to continue with the study | Enrollment / accrual |
| NCT02778412 | ctDNA in Patients With Thyroid Nodules | — | terminated | May 19, 2016 | Pathway Genomics | Preliminary results indicated that this test had a number of false-negative results. | Other (stated, no rule matched) |
| NCT01767961 | Modified Barium Swallow in Measuring Swallowing Function After Surgery in Patients With… | N/A | withdrawn | Jan 15, 2013 | Wake Forest University Health Sciences | Unable to secure funding. | Funding |
| NCT01545687 | CD2 Lozenges in Preventing Acute Oral Mucositis in Patients With Head and Neck Cancer… | Phase 3 | withdrawn | Mar 7, 2012 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT01114256 | FNA Tumor Sampling for CD137 Modulation: A Pilot Study | — | terminated | May 3, 2010 | Stanford University | not stated | Not stated |
| NCT00257335 | Intensity-Modulated Radiotherapy for Recurrent Head and Neck Cancer | Phase 2 | withdrawn | Nov 22, 2005 | Nilam Ramsinghani | Due to no patient enrollment this study was withdrawn/closed | Enrollment / accrual |
| NCT02726282 | Impact of Papillary Microcarcinoma Terminology on Patients Treatment Preferences: a Cross… | — | withdrawn | Apr 1, 2016 | Mayo Clinic | funding not available | Funding |
| NCT00503776 | Chemo/XRT +/- Amifostine to Assess Outcomes Related to Xerostomia, Mucositis, & Dysphagia | Phase 2 | terminated | Jul 19, 2007 | Vanderbilt-Ingram Cancer Center | funding became unavailable | Funding |
| NCT00591149 | Oxaliplatin and Docetaxel Followed by Cetuximab for Head and Neck Cancer | Phase 2 | terminated | Jan 11, 2008 | University of Kansas Medical Center | Study was stopped due to termination of funding | Funding |
| NCT01303237 | A Post Marketing Surveillance Study to Assess the Safety and Efficacy of Cetuximab Plus…(PMS LAD SCCHN) | — | terminated | Feb 24, 2011 | Merck KGaA, Darmstadt, Germany | The study was discontinued due to slow recruitment and subjects not completing follow up period. | Enrollment / accrual |
| NCT02593929 | Pharmacodynamic Effects and Predictive Biomarkers With Ruxolitinib in Operable Head and… | Early Phase 1 | withdrawn | Nov 2, 2015 | University of Pittsburgh | not stated | Not stated |
| NCT03161548 | A Study of Tongue Conservation Surgery for Oral Tongue Cancer | Phase 2 | terminated | May 22, 2017 | Taipei Veterans General Hospital, Taiwan | Diffiult patient recruitment | Enrollment / accrual |
| NCT00895245 | Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing… | Phase 2 | terminated | May 8, 2009 | University of Washington | Study stopped due to lack of efficacy in first 6 patients | Efficacy / futility |
| NCT01794845 | Cetuximab + Taxotere With Low Dose Fractionated Radiation for Head and Neck Carcinoma | Phase 2 | terminated | Feb 20, 2013 | University of Miami | Early termination due to lack of efficacy (overall response) | Efficacy / futility |
| NCT02196168 | Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or… | Phase 2 | terminated | Jul 21, 2014 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT02251639 | Diagnostic Aids for Detection and Diagnosis of Oral Cancer | Phase 1 | withdrawn | Sep 29, 2014 | M.D. Anderson Cancer Center | Study design improvements. | Other (stated, no rule matched) |
| NCT00937417 | S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors | Phase 1 | withdrawn | Jul 13, 2009 | SWOG Cancer Research Network | Withdrawn because SWOG no longer pursuing this study at this time | Other (stated, no rule matched) |
| NCT02567396 | Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be… | Phase 1 | withdrawn | Oct 5, 2015 | National Cancer Institute (NCI) | Other- Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT01267240 | Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head… | Phase 2 | terminated | Dec 28, 2010 | National Cancer Institute (NCI) | Study treatment did not show clinical activity. | Other (stated, no rule matched) |
| NCT00392665 | Bevacizumab/Tarceva and Tarceva/Sulindac in Squamous Cell Carcinoma of the Head and Neck | Phase 2 | terminated | Oct 26, 2006 | Massachusetts General Hospital | slow accrual | Enrollment / accrual |
| NCT01865838 | A Study Into the Effect of Seprafilm in Open Total Thyroidectomy | N/A | terminated | May 31, 2013 | National Cancer Centre, Singapore | safety issue | Safety / toxicity |
| NCT00482911 | Lenalidomide, Sunitinib, and Cyclophosphamide in Treating Patients With Stage IV Eye… | Phase 2 | terminated | Jun 5, 2007 | National Institutes of Health Clinical Center (CC) | Investigator left the institute. | Investigator |
| NCT00490061 | Lapatinib and Radiation for Stage III-IV Head and Neck Cancer Patients Who Cannot… | Phase 2 | terminated | Jun 22, 2007 | Quynh-Thu Le | Poor accrual. | Enrollment / accrual |
| NCT00101075 | Title XELOX FOR SALIVARY GLAND CANCERS | Phase 2 | terminated | Jan 10, 2005 | Dana-Farber Cancer Institute | Slow Accrual | Enrollment / accrual |
| NCT00903461 | Safety and Efficacy of Radiation/Cetuximab Plus EGFR Antisense DNA for Head and Neck… | Phase 1 | terminated | May 18, 2009 | University of Pittsburgh | drug supply issues | Drug supply |
| NCT00797290 | Photon/Proton Radiation Therapy for Carcinoma of the Nasopharynx(NP01) | — | terminated | Nov 25, 2008 | University of Florida | Slow enrollment, Feasibility issues | Enrollment / accrual |
| NCT02402348 | Pilot Study of Metformin in HNSCC to Investigate the Effects of MF, Tumor Genotype and… | Early Phase 1 | terminated | Mar 30, 2015 | West Virginia University | Funding not available, PI left institution | Investigator |
| NCT00797446 | Photon/Proton Radiation Therapy for Oropharyngeal Cancers(OP01) | — | terminated | Nov 25, 2008 | University of Florida | Slow enrollment, feasibility issues | Enrollment / accrual |
| NCT00256295 | Weekly Oxaliplatin and Gemcitabine for Recurrent or Metastatic Head and Neck Cancer | Phase 2 | terminated | Nov 21, 2005 | Sai-Hong Ignatius Ou | Low accrual | Enrollment / accrual |
| NCT00927147 | Boron Neutron Capture Therapy (BNCT) Combined With Cetuximab in the Treatment of Locally… | Phase 1 / Phase 2 | terminated | Jun 24, 2009 | Boneca Corporation | The neutron facility closed down for financial reasons. | Funding |
| NCT02281006 | Efficacy of Trans-tympanic Injections of a Sodium Thiosulfate Gel to Prevent…(STS001) | Phase 2 | terminated | Nov 3, 2014 | CHU de Quebec-Universite Laval | poor accrual | Enrollment / accrual |
| NCT02331875 | Efficacy Study of Pre-operative IPH2201 in Patients With Squamous Cell Carcinoma of the… | Phase 1 / Phase 2 | terminated | Jan 6, 2015 | Innate Pharma | lack of recruitment | Enrollment / accrual |
| NCT00412217 | A Study of Erlotinib (Tarceva) in Participants With Resected Head and Neck Squamous Cell… | Phase 3 | terminated | Dec 18, 2006 | Hoffmann-La Roche | The study was terminated because recruitment was too slow. | Enrollment / accrual |
| NCT01507467 | IAEA-HypoX. Accelerated Radiotherapy With or Without Nimorazole in Squamous Cell…(IAEA-HypoX) | Phase 3 | terminated | Jan 11, 2012 | Danish Head and Neck Cancer Group | Insufficient recruitment | Enrollment / accrual |
| NCT00721539 | Assessing the da Vinci® Robotic Surgical System for Surgery of the Upper Aerodigestive… | N/A | terminated | Jul 24, 2008 | Stanford University | Low Accrual | Enrollment / accrual |
| NCT01283178 | Phase I Study of IMRT and Molecular-Image Guided Adaptive Radiation Therapy for Advanced… | Phase 1 | terminated | Jan 25, 2011 | Virginia Commonwealth University | The study was terminated. The data analysis was futile with only 3 accruals. PI opted to terminate… | Enrollment / accrual |
| NCT02649530 | A Phase II Trial Evaluating WNT974 in Patients With Metastatic Head and Neck Squamous… | Phase 2 | withdrawn | Jan 7, 2016 | University of Michigan Rogel Cancer Center | funding withdrawn | Funding |
| NCT01910753 | Physical Activity Program and Nutrition Therapeutic Education During Treatment of Head…(APANVADS) | N/A | terminated | Jul 30, 2013 | University Hospital, Limoges | Not enough patients | Other (stated, no rule matched) |
| NCT01405846 | Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways…(TIDAL1) | Phase 2 | terminated | Jul 29, 2011 | Papworth Hospital NHS Foundation Trust | Futility | Efficacy / futility |
| NCT01975688 | A Pharmacokinetic Study of Single Doses of Sativex in Treatment-induced Mucositis | Phase 1 | terminated | Nov 5, 2013 | GW Pharmaceuticals Ltd | Slow recruitment | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 4, 2017source: clinicaltrials