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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
691 stopped studies mapped to Malignant Head and Neck Neoplasm and descendants · 92% state a reason
Over the 691 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01871311 | A Phase I Study of Nilontinib and Cetuximab in Patients With Solid Tumors | Phase 1 | terminated | Jun 6, 2013 | Georgetown University | Primary investigator left the institution. | Investigator |
| NCT03049358 | Olfactory Training in Improving Sense of Smell After Radiation Therapy in Patients With… | N/A | terminated | Feb 10, 2017 | Stanford University | Accrual factor | Enrollment / accrual |
| NCT00899704 | Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral… | — | withdrawn | May 12, 2009 | Alliance for Clinical Trials in Oncology | Study was never published | Other (stated, no rule matched) |
| NCT02388932 | Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced… | N/A | terminated | Mar 17, 2015 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT02205398 | Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and… | Phase 1 | terminated | Jul 31, 2014 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00828386 | Induction Chemotherapy and Chemoradiotherapy in Nasopharyngeal Cancers(NPC2006) | Phase 3 | terminated | Jan 23, 2009 | Groupe Oncologie Radiotherapie Tete et Cou | Low accrual | Enrollment / accrual |
| NCT00882583 | A Study of Dasatinib, Cetuximab and Radiation With or Without Cisplatin in HNSCC(Dasatinib) | Phase 1 | terminated | Apr 16, 2009 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low accrual | Enrollment / accrual |
| NCT00573989 | Intensity-Modulated Radiation Therapy, Pemetrexed, and Erlotinib in Treating Patients… | Phase 1 / Phase 2 | terminated | Dec 14, 2007 | Wake Forest University Health Sciences | Drug Supply Issue | Drug supply |
| NCT03246685 | Phase 2 Study of Imprime PGG & Pembrolizumab in Subjects With Adv SCCHN Who Failed Pembro… | Phase 2 | terminated | Aug 11, 2017 | HiberCell, Inc. | Due to enrollment challenges resulting in changing treatment patterns, the study has been… | Enrollment / accrual |
| NCT00100828 | Irinotecan in Treating Patients With Metastatic or Inoperable Thyroid Cancer | Phase 2 | terminated | Jan 7, 2005 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Closed due to early stopping rule | Other (stated, no rule matched) |
| NCT00923247 | A Targeted Phase I/II Trial of ZD6474 (Vandetanib; ZACTIMA) Plus the Proteasome… | Phase 1 / Phase 2 | terminated | Jun 18, 2009 | National Cancer Institute (NCI) | Terminated due to slow accrual,primary endpoint reached \& investigator left NIH. | Investigator |
| NCT01493154 | Safety Study of HPV DNA Vaccine to Treat Head and Neck Cancer Patients | Phase 1 | terminated | Dec 15, 2011 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Study Funding Terminated | Funding |
| NCT00102635 | 4-HPR and FTI in Head and Neck Squamous Cell Carcinoma (HNSCC) | Phase 1 | terminated | Feb 1, 2005 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT02442739 | Ketamine for Preventing Depression in Patients Undergoing Treatment for Pancreatic or… | Early Phase 1 | withdrawn | May 13, 2015 | Cedars-Sinai Medical Center | PI voluntary closure due to low accrual | Enrollment / accrual |
| NCT00926978 | Comparison of Iodine-124 (I-124) and Iodine-131 (I-131) Radiopharmacokinetics in Patients… | N/A | terminated | Jun 24, 2009 | Medstar Health Research Institute | Institutional RDRC dissolved | Other (stated, no rule matched) |
| NCT02947399 | Comparison of I-124 and I-131 Radiopharmacokinetics in DTC Patients With Thyroid Hormone… | N/A | terminated | Oct 27, 2016 | Medstar Health Research Institute | Institutional RDRC dissolved | Other (stated, no rule matched) |
| NCT03220009 | Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in… | Phase 2 | withdrawn | Jul 18, 2017 | National Cancer Institute (NCI) | The study was never approved by CTEP neither was it ever activated | Other (stated, no rule matched) |
| NCT00804830 | Avastin and Doxorubicin Postoperatively for Patients With Anaplastic Thyroid Cancer | Phase 2 | terminated | Dec 9, 2008 | Region Skane | lack of response | Other (stated, no rule matched) |
| NCT02694380 | Measuring the Effect of Radiation Therapy on Patient Activity Levels | — | terminated | Feb 29, 2016 | University of Pittsburgh | Low accrual | Enrollment / accrual |
| NCT01053546 | Effects of Swallowing Exercises on Patients Undergoing Radiation Treatment for Head and… | N/A | terminated | Jan 21, 2010 | Wake Forest University Health Sciences | slow accrual | Enrollment / accrual |
| NCT01732640 | A Phase I/II Study Afatinib/Carboplatin/Paclitaxel Induction Chemotherapy In HPV-Negative… | Phase 1 / Phase 2 | terminated | Nov 26, 2012 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Slow accrual and high levels of toxicity lead to early termination. | Safety / toxicity |
| NCT01852292 | Study of Efficacy and Safety of Buparlisib (BKM120) Plus Paclitaxel Versus Placebo Plus… | Phase 2 | terminated | May 13, 2013 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00894101 | Positron Emission Tomography Imaging With [F-18] FLT Compared to [F-18] FDG in Cancer… | Phase 2 / Phase 3 | withdrawn | May 6, 2009 | University of California, Irvine | The main sponsor of this multi-center trial has submitted this protocol. A single participating… | Other (stated, no rule matched) |
| NCT00416949 | Iodine I 131 in Treating Patients With Thyroid Cancer | N/A | terminated | Dec 28, 2006 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Study was terminated due to loss of funding. | Funding |
| NCT01009346 | RAD001 in Combination With Cetuximab and Cisplatin in Recurrent and Metastatic SCCHN | Phase 1 / Phase 2 | terminated | Nov 6, 2009 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Toxicity | Safety / toxicity |
| NCT00646659 | Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With… | Phase 2 | terminated | Mar 28, 2008 | European Organisation for Research and Treatment of Cancer - EORTC | Recruitment was suspended prematurely for safety concerns and closed after IDMC review | Safety / toxicity |
| NCT01164566 | Esophagoscopy in Evaluating Treatment in Patients With Stage I-IV Head and Neck Cancer… | N/A | terminated | Jul 16, 2010 | Wake Forest University Health Sciences | Inadequate Recruitment | Enrollment / accrual |
| NCT02552550 | Swallowing, Speech and Quality of Life of Patients With Carcinoma of the Oropharynx | — | terminated | Sep 17, 2015 | Centre Hospitalier Universitaire de Saint Etienne | rate of inclusion too low | Other (stated, no rule matched) |
| NCT00256308 | Adjuvant Chemoradiation With Weekly Oxaliplatin in Resected Head and Neck Cancer | Phase 2 | terminated | Nov 21, 2005 | University of California, Irvine | Halted prematurely due to slow accrual | Enrollment / accrual |
| NCT02543645 | A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer | Phase 1 | terminated | Sep 7, 2015 | Celldex Therapeutics | Portfolio re-prioritization | Sponsor / business decision |
| NCT00901537 | Azacitidine and Cisplatin in Patients With Advanced Lung or Head and Neck Cancer | Phase 1 | terminated | May 14, 2009 | Loma Linda University | Sponsor terminated due to no enrollments within last 4 months. | Enrollment / accrual |
| NCT02365662 | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced… | Phase 1 | terminated | Feb 19, 2015 | AbbVie | Safety | Safety / toxicity |
| NCT00004261 | EF5 Prior to Surgery or Biopsy in Patients With Breast, Prostate, or Cervical Cancer or… | Phase 1 | terminated | Dec 11, 2003 | University Health Network, Toronto | Lack of patient accrual | Enrollment / accrual |
| NCT01933269 | FACBC for Head and Neck Cancers | Early Phase 1 | withdrawn | Sep 2, 2013 | Emory University | Change in Principal Investigator and protocol revisions delayed study start and ultimately the… | Investigator |
| NCT01456143 | Optical Imaging of Head and Neck Cancer | N/A | terminated | Oct 20, 2011 | Sharmila Anandasabapathy, MD | PI left, study to be re-open with new PI, no planned data analysis | Investigator |
| NCT02170272 | Home-Based Lymphedema Care Program (HBLCP) in Improving Lymphedema Self-Care in Head and… | N/A | terminated | Jun 23, 2014 | Vanderbilt-Ingram Cancer Center | Unable to obtain funding | Funding |
| NCT01652456 | Alcohol and Tobacco Consumption in Patients With Head and Neck Cancer : Interest of an… | N/A | withdrawn | Jul 30, 2012 | Centre Oscar Lambret | not stated | Not stated |
| NCT01984892 | Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC)(Hiltonol) | Phase 2 | terminated | Nov 15, 2013 | Nina Bhardwaj | PI discretion, low enrollment | Enrollment / accrual |
| NCT00126568 | Sorafenib in Treating Patients With Advanced Anaplastic Thyroid Cancer | Phase 2 | terminated | Aug 4, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00319839 | Study of Albumin Bound-Paclitaxel for Treatment of Recurrent or Metastatic Head and Neck… | Phase 2 | terminated | Apr 27, 2006 | University of California, Irvine | slow accrual | Enrollment / accrual |
| NCT01488318 | Cetuximab and Dasatinib in Recurrent Squamous Cell Carcinoma | Phase 2 | terminated | Dec 8, 2011 | Julie E. Bauman, MD, MPH | PI leaving the institution | Other (stated, no rule matched) |
| NCT02628912 | Cardiopulmonary Fitness in Long-Term Survivors of HPV-related Oropharynx Cancers | — | withdrawn | Dec 11, 2015 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT03238638 | A Study of Epacadostat + Pembrolizumab in Head and Neck Cancer Patients, Who Failed Prior… | Phase 2 | withdrawn | Aug 3, 2017 | University of Chicago | PI did not attempt to open the study. | Other (stated, no rule matched) |
| NCT02993991 | Pre-operative Mocetinostat (MGCD0103) and Durvalumab (MEDI4736) (PRIMED) for Squamous…(PRIMED-001) | Phase 1 | withdrawn | Dec 15, 2016 | University Health Network, Toronto | The study has been terminated due to a change in internal prioritization and not due to any safety… | Safety / toxicity |
| NCT00352118 | Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced… | Phase 2 | terminated | Jul 14, 2006 | Masonic Cancer Center, University of Minnesota | Low dose radiation treatment was not appropriate for these patients. | Other (stated, no rule matched) |
| NCT01012362 | Study of Pazopanib and Ixabepilone in Patients With Solid Tumors | Phase 1 | terminated | Nov 13, 2009 | Masonic Cancer Center, University of Minnesota | PI left institution. | Investigator |
| NCT00360971 | Palifermin in Lessening Oral Mucositis in Patients Undergoing Radiation Therapy and… | Phase 3 | terminated | Aug 7, 2006 | Radiation Therapy Oncology Group | Due to positive preliminary results from other palifermin studies. | Other (stated, no rule matched) |
| NCT01051791 | Phase II Study of RAD001 Head and Neck Cancer | Phase 2 | terminated | Jan 20, 2010 | Julie E. Bauman, MD, MPH | not stated | Not stated |
| NCT02225496 | Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma | Phase 2 | terminated | Aug 26, 2014 | M.D. Anderson Cancer Center | Another trial in the department directly competes for the the same patient population | Other (stated, no rule matched) |
| NCT01221753 | Docetaxel/Cisplatin/5-Fluorouracil (TPF) Human Papillomavirus (HPV) Squamous Cell… | Phase 2 | terminated | Oct 15, 2010 | Dana-Farber Cancer Institute | Due to slow accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 8, 2019source: clinicaltrials