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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,225 stopped studies mapped to Malignant Genitourinary System Neoplasm and descendants · 88% state a reason
Over the 2,225 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01661868 | Olaparib for Patients With Recurrent BRCA Deficient Ovarian Cancer | Phase 2 | withdrawn | Aug 10, 2012 | Dana-Farber Cancer Institute | Drug not available. | Other (stated, no rule matched) |
| NCT00450970 | Expanded Access Study of Satraplatin Plus Prednisone in Patients With Hormone Refractory…(SPERA) | Phase 3 | terminated | Mar 22, 2007 | Agennix | Sponsor decided to discontinue study drug development. | Sponsor / business decision |
| NCT00388804 | External Beam Radiation Therapy (EBRT) With or Without Hormonal Therapy in Prostate Cancer | Phase 3 | terminated | Oct 17, 2006 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00147238 | A Validation Study of MR Lymphangiography Using SPIO, a New Lymphotropic… | N/A | terminated | Sep 7, 2005 | M.D. Anderson Cancer Center | Terminated at request of sponsor. | Other (stated, no rule matched) |
| NCT00085384 | PEG-Interferon Alfa-2b in Treating Patients With Platinum-Resistant Ovarian Epithelial,… | Phase 1 / Phase 2 | terminated | Jun 11, 2004 | M.D. Anderson Cancer Center | Terminated due to slow accrual. | Enrollment / accrual |
| NCT00901420 | Urodynamic Evaluation in Post-radiation Salvage Prostatectomy Patients | — | terminated | May 13, 2009 | M.D. Anderson Cancer Center | Terminated due to slow accrual. | Enrollment / accrual |
| NCT01070186 | Study of Sunitinib in Subjects With High Risk Renal Cell Carcinoma | Phase 2 | withdrawn | Feb 17, 2010 | Jonsson Comprehensive Cancer Center | No participants were enrolled. | Enrollment / accrual |
| NCT00811031 | Preoperative Docetaxel for Localized Progressive Castration-resistant Prostate Cancer… | Phase 2 | withdrawn | Dec 18, 2008 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00877617 | Quality of Life in Men With High Risk Localized Prostate Cancer | — | withdrawn | Apr 8, 2009 | M.D. Anderson Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00897806 | Identifying Genetic Markers That Predict Response to Paclitaxel in Patients With Newly… | — | terminated | May 12, 2009 | M.D. Anderson Cancer Center | Terminated due to slow accrual. | Enrollment / accrual |
| NCT00058266 | Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo… | Phase 2 | terminated | Apr 9, 2003 | Northwestern University | Data Monitoring Committee cited poor accrual. | Enrollment / accrual |
| NCT00471718 | ABT-751 in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to… | Phase 1 / Phase 2 | terminated | May 10, 2007 | Vanderbilt-Ingram Cancer Center | pharmaceutical company closed study because the treatment was not effective | Sponsor / business decision |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00127387 | Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia | Phase 2 / Phase 3 | terminated | Aug 5, 2005 | The University of Texas Health Science Center at San Antonio | PI moved to Oregon | Other (stated, no rule matched) |
| NCT01290406 | BEZ235 Trial in Patients With Advanced Endometrial Carcinoma | Phase 2 | withdrawn | Feb 7, 2011 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00881725 | A Study of Pre-operative Metformin in Prostate Cancer(ANIMATE) | Phase 2 | terminated | Apr 15, 2009 | University Health Network, Toronto | Slow Accrual | Enrollment / accrual |
| NCT01197820 | Hepatic and Renal Thermography Using Magnetic Resonance Imaging(THeR-IRM) | N/A | terminated | Sep 9, 2010 | University Hospital, Bordeaux | not stated | Not stated |
| NCT00057928 | S0227 Cisplatin With Either Paclitaxel or Gemcitabine in Recurrent, Persistent, or… | Phase 3 | withdrawn | Apr 9, 2003 | SWOG Cancer Research Network | lack of accrual | Enrollment / accrual |
| NCT00006262 | Rebeccamycin Analogue in Treating Patients With Refractory Stage III or Stage IV Ovarian… | Phase 2 | terminated | Mar 25, 2004 | Northwestern University | Unable to accrue patients to the study. | Enrollment / accrual |
| NCT01313104 | Colposcopy and High Resolution Anoscopy in Screening For Anal Dysplasia in Patients With… | N/A | withdrawn | Mar 11, 2011 | Northwestern University | Lack of funding | Funding |
| NCT00050297 | YM598 in Patients With Rising PSA After Initial Therapy for Localized Prostate Cancer | Phase 2 | terminated | Dec 4, 2002 | Astellas Pharma Inc | not stated | Not stated |
| NCT00242931 | Flu/TBI in Treating Patients Not Responding to Previous Hormone Therapy | Phase 2 | withdrawn | Oct 21, 2005 | OHSU Knight Cancer Institute | Unable to successfully recruit subjects to this study. | Enrollment / accrual |
| NCT00243009 | Fludarabine and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor… | Phase 2 | terminated | Oct 21, 2005 | OHSU Knight Cancer Institute | Due to a lack of a referal base, study was terminated. | Other (stated, no rule matched) |
| NCT00244920 | Hormone Therapy With or Without Squalamine Lactate in Treating Patients Who Are… | Phase 2 | withdrawn | Oct 27, 2005 | OHSU Knight Cancer Institute | Sponsor withdrew drug. | Other (stated, no rule matched) |
| NCT01031056 | Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers | — | withdrawn | Dec 14, 2009 | Stanford University | Change in research focus | Other (stated, no rule matched) |
| NCT00073970 | Celecoxib in Treating Patients With Relapsed Prostate Cancer Following Radiation Therapy… | Phase 2 | terminated | Dec 11, 2003 | UNC Lineberger Comprehensive Cancer Center | Study stopped due to increased cardiovascular risks associated with Celebrex | Other (stated, no rule matched) |
| NCT00237575 | Randomized Phase III Trial of Leukine® vs Neupogen® in Patients Receiving Cisplatin &… | Phase 3 | terminated | Oct 12, 2005 | University of Kentucky | not stated | Not stated |
| NCT00653328 | Ph II Atrasentan + DOXIL in Recurrent Ovarian/Fallopian/Peritoneal Serous Papillary… | Phase 2 | terminated | Apr 4, 2008 | Vanderbilt-Ingram Cancer Center | Abbott (drug manufacturer) discontinued manufacture of ABT-627 | Drug supply |
| NCT00311467 | Combined Treatment With Capecitabine and Immunotherapy Versus Immunotherapy Alone in… | Phase 3 | terminated | Apr 6, 2006 | Central European Cooperative Oncology Group | no patient recruitment | Enrollment / accrual |
| NCT00313456 | A Phase I Study of the Oral Platinum Agent Satraplatin in Combination With Weekly… | Phase 1 | terminated | Apr 12, 2006 | Agennix | Sponsor decided to discontinue study drug development | Sponsor / business decision |
| NCT00294437 | ZOMETA® (Zoledronic Acid) for Prevention of Bone Metastases | Phase 3 | terminated | Feb 22, 2006 | Central European Cooperative Oncology Group | underfunding | Other (stated, no rule matched) |
| NCT00100685 | Study of M200 (Volociximab) in Patients With Metastatic Renal Cell Carcinoma (RCC) | Phase 2 | terminated | Jan 5, 2005 | Abbott | not stated | Not stated |
| NCT00911027 | SonoVue Guided Prostate Biopsy | Phase 3 | terminated | Jun 1, 2009 | Bracco Diagnostics, Inc | Failure to meet primary objective | Other (stated, no rule matched) |
| NCT00005827 | Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer | Phase 1 | withdrawn | Apr 20, 2004 | UNC Lineberger Comprehensive Cancer Center | not stated | Not stated |
| NCT00231829 | A Pilot Study of Celecoxib in Patients With Grade 2 or 3 Uterine Cancers | Phase 2 | terminated | Oct 4, 2005 | Mark H. Einstein | Due to reported toxicity of Celecoxib at high doses | Safety / toxicity |
| NCT00813254 | Cost Utility Analysis in Recurrent Ovarian Cancer | — | withdrawn | Dec 23, 2008 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01033981 | Cost Effectiveness Of Sunitinib In Central America And Caribbean | — | terminated | Dec 17, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT00505661 | Letrozole in Patients With Ovarian Tumors | Phase 2 | terminated | Jul 23, 2007 | M.D. Anderson Cancer Center | Terminated due to slow patient accrual. | Enrollment / accrual |
| NCT00820287 | Identification of Predictive Markers for Testis Cancer in a Population of Men With High… | N/A | terminated | Jan 12, 2009 | Centre Hospitalier Universitaire de Nice | not stated | Not stated |
| NCT00480623 | A Phase I Trial of Satraplatin Plus Radiation Therapy for Prostate Cancer Patients With… | Phase 1 | terminated | May 31, 2007 | Agennix | Sponsor decided to discontinue study drug development | Sponsor / business decision |
| NCT00253461 | 11C Topotecan PET Imaging | Early Phase 1 | terminated | Nov 15, 2005 | Case Comprehensive Cancer Center | Drugs unavailable:unable to make radioactive topotecan | Other (stated, no rule matched) |
| NCT00445757 | Stereotactic Radiation Therapy in Treating Patients With Kidney Tumors | Phase 1 | withdrawn | Mar 9, 2007 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT01340599 | Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer… | Phase 2 | terminated | Apr 22, 2011 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00003824 | S9809, Ciprofloxacin Compared With Cephalexin in Treating Patients With Bladder Cancer | Phase 3 | terminated | Apr 14, 2004 | SWOG Cancer Research Network | Permanently Closed Due to Poor Accrual | Enrollment / accrual |
| NCT00485563 | A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive… | Phase 2 | terminated | Jun 13, 2007 | Endocyte | Changes in treatment paradigm resulted in a lower than expected rate of accrual. | Enrollment / accrual |
| NCT00003640 | Transurethral Resection and Combination Chemotherapy in Treating Patients With Stage II… | Phase 2 | terminated | May 20, 2004 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00003642 | Radiation Therapy and Chemotherapy Following Surgery in Treating Patients With Stage II… | Phase 2 | terminated | Apr 9, 2004 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00773318 | SPECT-CT Guided Lymphatic Mapping and Sentinel Lymphadenectomy (LM/SL) in Prostate Cancer | N/A | terminated | Oct 16, 2008 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1 patient has been enrolled. No complications reported. The research team decided to terminate the… | Enrollment / accrual |
| NCT00989105 | Technetium Tc 99m Demobesin-4 for Imaging Procedures in Patients With Prostate Cancer | Phase 1 | terminated | Oct 2, 2009 | Cancer Research UK | not stated | Not stated |
| NCT01132599 | Comparing PET-CT Using C-11 Choline and 18F-Fluoromethylcholine in Patients With… | Phase 2 | withdrawn | May 28, 2010 | Cancer Research UK | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 21, 2012source: clinicaltrials