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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,225 stopped studies mapped to Malignant Genitourinary System Neoplasm and descendants · 88% state a reason
Over the 2,225 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00091195 | Depsipeptide (Romidepsin) in Treating Patients With Recurrent Ovarian Epithelial or… | Phase 2 | terminated | Sep 9, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01478308 | Metformin With Standard Taxotere and Prednisone in the Treatment of Castration Resistant… | Phase 2 | withdrawn | Nov 23, 2011 | New Mexico Cancer Research Alliance | No accrual in initial period, PI decided to close study. | Enrollment / accrual |
| NCT00429026 | Conditioning Regimen in Nonmyeloablative Allogeneic Hematopoietic Stem Cell… | Phase 2 | terminated | Jan 31, 2007 | M.D. Anderson Cancer Center | Slow accrual, study terminated. | Enrollment / accrual |
| NCT00601120 | RF Ablation of Treatment of Metastatic Lesions in Patients Undergoing Antiangiogenic… | N/A | withdrawn | Jan 25, 2008 | Beth Israel Deaconess Medical Center | This protocol was never officially opened and no patients were recruited. | Enrollment / accrual |
| NCT00816686 | A Phase 1 Study of the Safety and Pharmacokinetics of AGS-16M18 in Subjects With Advanced… | Phase 1 | terminated | Jan 5, 2009 | Astellas Pharma Inc | Trial was terminated due to the need to re-formulate the study drug. | Other (stated, no rule matched) |
| NCT01016054 | A Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With… | Phase 1 | terminated | Nov 18, 2009 | Astellas Pharma Inc | Trial was terminated to allow sponsors to evaluate the future development of the drug program | Other (stated, no rule matched) |
| NCT00311545 | S0351, CNTO 328 in Treating Patients With Unresectable or Metastatic Kidney Cancer | Phase 2 | withdrawn | Apr 6, 2006 | SWOG Cancer Research Network | withdrawal of support for drug supply | Drug supply |
| NCT00005808 | Photodynamic Therapy Using Lutetium Texaphyrin in Treating Patients With Cervical… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00559481 | Ketoconazole, Dexamethasone, and Hydrocortisone in Treating Patients With Prostate Cancer… | N/A | withdrawn | Nov 16, 2007 | Roswell Park Cancer Institute | Withdrawn due to low accrual | Enrollment / accrual |
| NCT00383487 | A Phase II Trial of Calcitriol and Naproxen in Patients With Recurrent Prostate Cancer | Phase 2 | terminated | Oct 3, 2006 | Stanford University | Extreme toxicity | Safety / toxicity |
| NCT00523809 | Allogeneic Hematopoietic Stem Cell Transplantation With Bevacizumab for Advanced Solid… | Phase 2 | terminated | Sep 3, 2007 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00005039 | Vaccine Therapy in Treating Patients With Advanced Adenocarcinoma of the Prostate… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00137358 | Radiation With Chemotherapy and a Study Drug to the Para-Aortic Nodes in Cervical Cancer | Phase 1 | withdrawn | Aug 29, 2005 | University of Alabama at Birmingham | unable to obtain funding to conduct study | Funding |
| NCT00009919 | SU5416 in Treating Patients With Metastatic Kidney Cancer That Has Not Responded to… | Phase 2 | terminated | Jan 1, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042952 | Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01700010 | Trial of Lapatinib and Weekly Paclitaxel for Advanced Urothelial Cancer | Phase 2 | withdrawn | Oct 4, 2012 | University of Michigan Rogel Cancer Center | Funding issues. | Funding |
| NCT00005067 | Photodynamic Therapy With Lutetium Texaphyrin in Treating Patients With Locally Recurrent… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00052585 | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01245660 | A Phase 0 of Neoadjuvant Lapatinib in Infiltrative Bladder Carcinoma Before Cystectomy(LAPAINBLAD) | Early Phase 1 | terminated | Nov 22, 2010 | University Hospital, Bordeaux | The rythm of enrollment was not compatible with the objective of recruitement in the research. | Enrollment / accrual |
| NCT00512668 | Hormone Therapy and Temsirolimus in Treating Patients With Relapsed Prostate Cancer | Phase 1 | terminated | Aug 8, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00173407 | PTEN and IGFBP-3 Correlation in Ovarian Carcinoma Invasion | N/A | withdrawn | Sep 15, 2005 | National Taiwan University Hospital | not stated | Not stated |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT00840450 | Imatinib Mesylate (Gleevec) and Paclitaxel in Recurrent Patients of Ovarian and Other… | Phase 2 | terminated | Feb 10, 2009 | NYU Langone Health | Due to slow accrual | Enrollment / accrual |
| NCT01177501 | Trial of High Dose Topotecan With Carboplatin in Patients With Relapsed Ovarian Carcinoma(ITOV04) | Phase 1 | terminated | Aug 9, 2010 | Assistance Publique - Hôpitaux de Paris | choice of the principal investigator | Investigator |
| NCT01226888 | Changes in Brown Adipose Tissue Activity In Men Receiving Androgen Deprivation Therapy… | — | terminated | Oct 22, 2010 | Massachusetts General Hospital | Slow accrual | Enrollment / accrual |
| NCT00087295 | S0400, FR901228 in Treating Patients With Advanced Cancer of the Urothelium | Phase 2 | terminated | Jul 12, 2004 | SWOG Cancer Research Network | Permanently Closed Due to Poor Accrual | Enrollment / accrual |
| NCT00919022 | Androcur Non-interventional Study Among Patients With Carcinoma of the Prostate(ANES) | — | terminated | Jun 11, 2009 | Bayer | not stated | Not stated |
| NCT00714376 | Phase II Study of Docetaxel for Clinically Asymptomatic High Risk Prostate Cancer Patients(TAX1) | Phase 2 | terminated | Jul 14, 2008 | CHU de Quebec-Universite Laval | Prematurely terminated due to financial considerations | Funding |
| NCT01551407 | Detection of Bladder Tumors After 30 Min Instillation of Hexvix | Phase 2 | terminated | Mar 12, 2012 | Photocure | slow inclusion rate | Other (stated, no rule matched) |
| NCT00492440 | Interleukin-7 in Treating Patients With Metastatic Melanoma or Locally Advanced or… | Phase 1 | terminated | Jun 27, 2007 | Cytheris SA | not stated | Not stated |
| NCT00293371 | Docetaxel, Prednisone, and Vatalanib in Treating Patients With Advanced Prostate Cancer | Phase 1 / Phase 2 | terminated | Feb 17, 2006 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00313534 | Nordihydroguaiaretic Acid in Treating Patients With Nonmetastatic Relapsed Prostate Cancer | Phase 1 | terminated | Apr 12, 2006 | University of California, San Francisco | Ran out of drug | Other (stated, no rule matched) |
| NCT00379119 | Effect of Androgen Blockade Therapy on Thymus Function in Older Patients Who Have… | — | terminated | Sep 21, 2006 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00288275 | Correlation of the Chemoresponse Assay With PFS in Patients With Recurrent Epithelial… | — | terminated | Feb 7, 2006 | Precision Therapeutics | not stated | Not stated |
| NCT00669422 | ChemoFx® PRO - A Post-Market Data Collection Study | — | terminated | Apr 30, 2008 | Precision Therapeutics | not stated | Not stated |
| NCT00460200 | Depression and Interleukin-6 Production in Patients With Ovarian Epithelial Cancer | — | withdrawn | Apr 13, 2007 | Jonsson Comprehensive Cancer Center | no patient accrual | Enrollment / accrual |
| NCT00006371 | A Phase II Trial of Early Medical Adrenalectomy for "D0.5" Prostate Cancer | Phase 2 | terminated | Apr 2, 2004 | H. Lee Moffitt Cancer Center and Research Institute | low accrual | Enrollment / accrual |
| NCT00005612 | Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating…(ETC) | Phase 1 / Phase 2 | terminated | May 3, 2004 | H. Lee Moffitt Cancer Center and Research Institute | Low accrual | Enrollment / accrual |
| NCT00006356 | Chemotherapy With or Without Surgery in Treating Patients With Recurrent Ovarian Cancer | Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00014586 | Bicalutamide Compared With Observation Followed by Bicalutamide Plus Either Goserelin or… | Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00042887 | Chemotherapy With or Without Surgery in Treating Patients With Bladder Cancer | Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT01663415 | A Study to Evaluate the Safety and Efficacy of Enzalutamide in Chemotherapy-Naïve,… | Phase 2 | withdrawn | Aug 13, 2012 | Astellas Pharma Global Development, Inc. | A business decision was made to not initiate this study. | Sponsor / business decision |
| NCT00496080 | Doppler-Guided Uterine Artery Occlusion (DUAO) Device for Fibroid Related Bleeding(DUAO) | N/A | terminated | Jul 4, 2007 | Ethicon, Inc. | Trial terminated early due to results from a similar study. | Other (stated, no rule matched) |
| NCT00082459 | Trial to Compare the Routes of Administration of an Investigational, Personalized,… | Phase 2 | terminated | May 12, 2004 | Agenus Inc. | Lack of enrollment | Enrollment / accrual |
| NCT00126178 | Clinical Trial Studying a Personalized Cancer Vaccine in Patients With Non-metastatic… | Phase 3 | terminated | Aug 3, 2005 | Agenus Inc. | not stated | Not stated |
| NCT00626548 | A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Non-metastatic…(ENTHUSE M0) | Phase 3 | terminated | Feb 29, 2008 | AstraZeneca | early efficacy review by the Independent Data Monitoring Committee indicated it was unlikely to… | Efficacy / futility |
| NCT00516841 | A Phase 2, Single-Arm Study of Volociximab Monotherapy in Subjects With… | Phase 2 | terminated | Aug 16, 2007 | Facet Biotech | Decision to terminate recruitment based on lack of efficacy | Efficacy / futility |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Mar 19, 2013source: clinicaltrials