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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Genitourinary System Neoplasm and descendants · 88% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00659399 | Feasibility Study of Short Term Fondaparinux (Arixtra) in Chemotherapy-Pretreated Ovarian… | Phase 1 | withdrawn | Apr 16, 2008 | NYU Langone Health | Low accrual | Enrollment / accrual |
| NCT00933374 | Trial to Evaluate Paclitaxel Plus RAD001 in Urothelial Carcinoma(RAD001) | Phase 2 | terminated | Jul 7, 2009 | Heinrich-Heine University, Duesseldorf | delayed recruitment | Enrollment / accrual |
| NCT01017809 | Prolonged Emend in a Study (NYU 03-67) of Oxaliplatin and Topotecan in Previously Treated… | N/A | withdrawn | Nov 23, 2009 | NYU Langone Health | NYU 03-67 reached accrual prior to this study opening. | Enrollment / accrual |
| NCT01539187 | Fibroid Ablation Study - Large Fibroids(FAST-L) | N/A | terminated | Feb 27, 2012 | Gynesonics | Investigational device changes | Other (stated, no rule matched) |
| NCT01998854 | Observational Prospective Study on Patients With Symptomatic Uterine Fibroids Treated… | — | terminated | Dec 2, 2013 | Gynesonics | Investigational device changes | Other (stated, no rule matched) |
| NCT00442598 | Safety and Efficacy Study of Glufosfamide in Ovarian Cancer | Phase 2 | terminated | Mar 2, 2007 | Eleison Pharmaceuticals LLC. | not stated | Not stated |
| NCT00023634 | S0114 Vaccine Therapy in Treating Patients With Gastric, Prostate, or Ovarian Cancer | Phase 1 | terminated | Jan 27, 2003 | SWOG Cancer Research Network | lack of accrual | Enrollment / accrual |
| NCT00694291 | Sorafenib in Hormone Naïve Biochemical Recurrence of Prostate Cancer | Phase 2 | withdrawn | Jun 10, 2008 | Fox Chase Cancer Center | not stated | Not stated |
| NCT00918008 | A 12-Gene Blood-Based Signature for Detecting Metastatic Bladder Cancer | — | terminated | Jun 11, 2009 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01163448 | Feasibility and Safety Study Using Preoperative High-Dose Single-Fraction Image-Guided… | Phase 1 | withdrawn | Jul 15, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01565512 | Dorsal Penile Block for Post-Robotic Prostatectomy Foley Discomfort | Phase 1 / Phase 2 | withdrawn | Mar 28, 2012 | Columbia University | Lack of funding, PI left the institution, poor enrollment | Investigator |
| NCT00058214 | Perifosine in Treating Patients With Recurrent Prostate Cancer | Phase 2 | terminated | Apr 9, 2003 | National Cancer Institute (NCI) | Did not meet interim stopping criteria for continuation to the second stage. | Other (stated, no rule matched) |
| NCT02312804 | Ph Ib/BGJ398/Cervix and Other Solid Tumors | Phase 1 | withdrawn | Dec 9, 2014 | The University of Texas Health Science Center at San Antonio | Drug not available. | Other (stated, no rule matched) |
| NCT01720693 | Novel Controlled Hypo-Perfusion Technique in Partial Nephrectomy | Phase 2 | terminated | Nov 2, 2012 | University Health Network, Toronto | Low accrual | Enrollment / accrual |
| NCT00539968 | A Study to Evaluate the Safety, Tolerability, and Activity of Lonafarnib and Docetaxel… | Phase 1 / Phase 2 | terminated | Oct 5, 2007 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01353794 | Study to Observe Safety and Efficacy of Nexavar in Treatment of Kidney Cancer(POWER-NEXT) | — | withdrawn | May 16, 2011 | Bayer | not stated | Not stated |
| NCT02159690 | A Phase II Neoadjuvant Study of Enzalutamide, Abiraterone Acetate, Dutasteride and… | Phase 2 | withdrawn | Jun 10, 2014 | Kenneth Pienta, MD | loss of funding | Funding |
| NCT02065323 | A Study of Dovitinib With Androgen Deprivation Therapy (ADT) in Patients With Metastatic… | Phase 2 | withdrawn | Feb 19, 2014 | Oscar Goodman, Jr. | Terminated due to budgetary considerations and length of development. | Funding |
| NCT00312650 | Doxil and Gemcitabine in Recurrent Ovarian Cancer | Phase 2 | terminated | Apr 10, 2006 | Women and Infants Hospital of Rhode Island | not stated | Not stated |
| NCT00429338 | 3T Endorectal Magnetic Resonance Spectroscopic Imaging (MRSI) of Prostate | N/A | terminated | Jan 31, 2007 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00824902 | Evaluation Ultrasound Elasticity/Tissue Strain-Hardening Imaging for Prostate Cancer… | N/A | terminated | Jan 19, 2009 | M.D. Anderson Cancer Center | Technical Issues | Other (stated, no rule matched) |
| NCT00511576 | Study to Evaluate Combination Treatment of MGCD0103 and Docetaxel (Taxotere®) for… | Phase 1 | terminated | Aug 6, 2007 | Mirati Therapeutics Inc. | Celgene terminated its collaboration agreement with MethylGene for the development of MGCD0103. All… | Other (stated, no rule matched) |
| NCT01950871 | Prostate Guided Biopsy Study Evaluating the Diagnostic Performance of Prostate…(PHSTT-01) | Phase 4 | terminated | Sep 26, 2013 | Advanced Medical Diagnostics s.a. | Sponsor is bankrupt | Other (stated, no rule matched) |
| NCT01492920 | Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With… | Phase 3 | withdrawn | Dec 15, 2011 | Gynecologic Oncology Group | Withdrawn | Other (stated, no rule matched) |
| NCT00352859 | Phase IV Randomization to On-Going Treatment to Evaluate Sustained Sorafenib | Phase 4 | terminated | Jul 17, 2006 | Bayer | not stated | Not stated |
| NCT00072137 | Neoadjuvant Intravesical Vaccine Therapy in Treating Patients With Bladder Carcinoma Who… | Phase 1 | terminated | Nov 6, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01927393 | Palliative Care in Improving Quality of Life and Symptoms in Patients With Stage III-IV… | N/A | withdrawn | Aug 22, 2013 | City of Hope Medical Center | Study was not funded | Funding |
| NCT00622479 | Mechanistic Evaluation on Sorafenib Induced Hypophosphatemia. | Phase 1 | terminated | Feb 25, 2008 | Bayer | not stated | Not stated |
| NCT01777230 | The Value of Preoperative Sentinel Lymph Node Mapping by Pelvic MR Lymphangiography and… | — | withdrawn | Jan 28, 2013 | UMC Utrecht | Unable to get required research materials | Other (stated, no rule matched) |
| NCT00624962 | Early Enteral Tube Feedings in Children Receiving Chemo for AML/MDS & High Risk Solid… | N/A | withdrawn | Feb 28, 2008 | Vanderbilt University | no participants enrolled | Enrollment / accrual |
| NCT00678288 | A Study to Assess Sorafenib Alone and in Combination With Low-Dose Interferon Following… | Phase 2 | terminated | May 15, 2008 | Bayer | not stated | Not stated |
| NCT01838265 | Trial of Prostate Cancer Patients Undergoing Active Surveillance With or Without…(MGM) | — | withdrawn | Apr 24, 2013 | University of Miami | Unlikely to Accrue | Enrollment / accrual |
| NCT01747239 | Cabazitaxel in Platinum Refractory Ovarian Cancer | Phase 2 | terminated | Dec 11, 2012 | Vejle Hospital | Too low inclusion rate. Only 4 patients included over 16 months | Other (stated, no rule matched) |
| NCT01469338 | Cabazitaxel Plus Prednisone With Octreotide For Castration-Resistant Prostate Cancer… | Phase 2 | terminated | Nov 10, 2011 | University of Southern California | lack of funding | Funding |
| NCT00393796 | Trial of Maintenance SUO11248 Versus Placebo Post Chemotherapy for Patients With Advanced… | Phase 2 | terminated | Oct 30, 2006 | University of Michigan Rogel Cancer Center | Low accrual | Enrollment / accrual |
| NCT00787488 | Pilot Study of IV and IP Chemotherapy Plus Abdominal Hyperthermia for Ovarian Ca | N/A | withdrawn | Nov 7, 2008 | Mark Dewhirst | Study not funded | Funding |
| NCT01531205 | Neoadjuvant Chemohormonal Therapy Followed by Salvage Surgery for High Risk PSA | Phase 2 | terminated | Feb 10, 2012 | H. Lee Moffitt Cancer Center and Research Institute | low accrual | Enrollment / accrual |
| NCT00753220 | Safety Study of Autologous Dendritic Cells Injected Into the Prostate After Cryoablation…(CRITICAL) | Phase 1 / Phase 2 | terminated | Sep 16, 2008 | Bostwick Laboratories | Withdrew the IND with the FDA. | Other (stated, no rule matched) |
| NCT00918385 | Genomic Guided Therapy With Dasatinib or Nilutamide in Metastatic Castration-Resistant…(ARS) | Phase 2 | terminated | Jun 11, 2009 | Duke University | Permanent closure of trial to further accrual based on IDE disapproval | Enrollment / accrual |
| NCT01320787 | 18-F-Fluoroacetate as PET Imaging Agent | Phase 1 | withdrawn | Mar 22, 2011 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01020305 | Temsirolimus to Reverse Androgen Insensitivity for Castration-resistant Prostate Cancer | Phase 1 / Phase 2 | terminated | Nov 25, 2009 | Sandy Srinivas | Decision by funding sponsor due to poor accrual | Enrollment / accrual |
| NCT01486550 | Hydroxyethyl Starch and Renal Function After Laparoscopic Nephrectomy(VONE) | Phase 4 | terminated | Dec 6, 2011 | Regional Hospital Holstebro | Lack of patient enrollment | Enrollment / accrual |
| NCT00384891 | Hyperthermia Treatment in Conjunction With Mitomycin C Versus Bacillus Calmette-Guérin… | Phase 3 | terminated | Oct 6, 2006 | Medical Enterprises Europe B.V. | slow accrual | Enrollment / accrual |
| NCT01149434 | Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or… | Phase 1 / Phase 2 | terminated | Jun 23, 2010 | University of Utah | Lack of drug efficacy | Efficacy / futility |
| NCT01095367 | Seprafilm™ for the Prevention of Intraperitoneal Adhesions and Improved Delivery of… | N/A | terminated | Mar 30, 2010 | University of British Columbia | due to company changes and lack of funding-unlikely to have sufficient numbers to analyze… | Funding |
| NCT02013765 | A Study of Herceptin (Trastuzumab) Monotherapy in Patients With Metastatic Urothelial… | Phase 2 | terminated | Dec 17, 2013 | Hoffmann-La Roche | Trial was terminated prematurely because of recruitment difficulties. | Enrollment / accrual |
| NCT01704027 | Safety Study of Pelvic and Prostatic SIB-IMRT With Long-term Androgen Deprivation for… | Phase 2 | terminated | Oct 11, 2012 | Centre Georges Francois Leclerc | termination of the trial after interim analysis. the main criterion could not be reached | Efficacy / futility |
| NCT02017678 | Phase 2 Study of JX-594 in Patients With Peritoneal Carcinomatosis of Ovarian Cancer… | Phase 2 | withdrawn | Dec 23, 2013 | Andrea McCart | not stated | Not stated |
| NCT01943058 | Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients… | Phase 2 | withdrawn | Sep 16, 2013 | University of Southern California | Lack of funding | Funding |
| NCT01786226 | Mifepristone to Treat Uterine Fibroids | Phase 2 / Phase 3 | terminated | Feb 7, 2013 | Mediterranea Medica S. L. | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Mar 18, 2015source: clinicaltrials