Clinical trial · Interventional
Hydroxyethyl Starch and Renal Function After Laparoscopic Nephrectomy
Effect of Hydroxyethyl Starch on Renal Handling of Salt and Water, Blood Pressure-regulating Hormones, Proteins and Circulatory System of Patients Undergoing Kidney Removal by Keyhole Surgery
NCT01486550CI-TRIAL-00015819VONEterminatedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Lack of patient enrollment
Summary
Brief summary (as posted)
The purpose of this project is to investigate if hydroxyethyl starch (HES) is potential nephrotoxic and examine the effects on the circulation and kidneys during administration of HES during surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Kidney Cancer | Malignant Kidney Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Sodium Chloride 9mg/ml | Drug | — | UNRESOLVED |
| Voluven (Hydroxyethyl starch 130/0,4) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Voluven (Hydroxyethyl starch 130/0,4)
- description
- Patients undergoing laparoscopic nephrectomy will receive either fluid therapy with active comparator (Voluven) or placebo (Sodium Chloride)
- interventionNames
- Drug: Voluven (Hydroxyethyl starch 130/0,4)
- type
- PLACEBO_COMPARATOR
- label
- Sodium Chloride 9mg/ml
- description
- Patients undergoing laparoscopic nephrectomy will receive either fluid therapy with active comparator (Voluven) or placebo (Sodium Chloride)
- interventionNames
- Drug: Sodium Chloride 9mg/ml
Primary outcomes (1)
- measure
- u-NGAL
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \> 18 years * Males and females * Indication for laparoscopic nephrectomy Exclusion Criteria: * Blood donation within the last month * Lack of wish to participate * eGFR\< 15ml/min * Pregnancy or breast feeding
References
Publications (0)
Data not yet available
No reference posted for this study.